Impaired flow-mediated vasodilation of the brachial artery in patients with primary hyperparathyroidism improves after parathyroidectomy.


OBJECTIVE:The endothelium is a newly recognised target tissue of parathyroid hormone (PTH). It is not clear whether hyperparathyroidism affects endothelial function and whether parathyroidectomy (Ptx) has an influence on arterial vessel wall properties. We studied brachial flow-mediated vasodilation (FMD) and brachial and carotid intima-media thickness (IMT) in patients with primary hyperparathyroidism (pHPT) before and after Ptx and in healthy controls. METHODS:19 patients with pHPT (mean+SEM, age 45+/-4.7 years, PTH 238+/-52 ng/l) were studied. Diabetes, hypertension and vascular disease were excluded. Twenty healthy volunteers matched for age, sex and blood pressure served as controls. Enddiastolic diameter, FMD and nitroglycerine-induced (NMD) dilation of the brachial artery were measured by a multigate pulsed doppler system (echo-tracking), IMT was determined using automatic analysis of the M-line signal. Healthy volunteers where studied on one occasion, patients were studied at baseline and 6 months after Ptx. RESULTS:Six months after Ptx PTH had decreased to normal, blood pressure levels remained unchanged. Endothelium dependent FMD at baseline was impaired in patients compared to controls (4.7+/-1.2 vs. 18.2+/-3.7%, P<0.01), however, FMD improved significantly after Ptx (16.7+/-3.0%, P<0.01). Nitroglycerine-induced dilation, IMT and artery diameter were not different between groups and did not change after Ptx. CONCLUSIONS:Impaired endothelium dependent vasodilation in patients with primary hyperparathyroidism improves after successful parathyroidectomy. Endothelial dysfunction associated with primary hyperparathyroidism occurs without detectable structural wall alterations of the brachial artery and appears therefore to be an early and reversible arterial alteration.


Cardiovasc Res


Cardiovascular research


Kosch M,Hausberg M,Vormbrock K,Kisters K,Gabriels G,Rahn KH,Barenbrock M




Has Abstract


2000-09-01 00:00:00














  • Stretch-induced modifications of myocardial performance: from ventricular function to cellular and molecular mechanisms.

    abstract::The purpose of this review is to give an integrative view of the effect of stretch on the myocardium from ventricular function changes to cellular and molecular mechanisms. The general approach will be to discuss the cellular and molecular events which can explain the findings obtained in the whole ventricle. Followin...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Crozatier B

    更新日期:1996-07-01 00:00:00

  • Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits.

    abstract:OBJECTIVE:The highly selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyl-adenosine (CCPA), has been shown to be as cardioprotective as ischaemic preconditioning when evaluated with an early staining method using tetrazolium. However, tetrazolium-positive tissue measured 3 h after reperfusion may still over...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Tsuchida A,Liu GS,Wilborn WH,Downey JM

    更新日期:1993-04-01 00:00:00

  • Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement.

    abstract:OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Armstrong S,Ganote CE

    更新日期:1994-07-01 00:00:00

  • Changes in regional myocardial blood flow and variable development of hypertrophy after aortic banding in puppies.

    abstract::Supravalvar aortic banding was performed in 6 to 12 week puppies. Sixteen animals were studied 7.3 (3.5 to 10) months later, closed-chested under morphine-chloralose, catheters being positioned in the great vessels and heart, including the left atrium for microsphere injection. Compared with 11 controls, eight dogs de...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Einzig S,Leonard JJ,Tripp MR,Lucas RV,Swayze CR,Fox IJ

    更新日期:1981-12-01 00:00:00

  • Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.

    abstract::Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

    更新日期:2005-10-01 00:00:00

  • Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits.

    abstract:OBJECTIVES:We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF). METHODS:We measured renal sympathetic nerve activity (RSNA) in response to graded hypoxia before and after intravenous administration of Ang II (...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Li YL,Xia XH,Zheng H,Gao L,Li YF,Liu D,Patel KP,Wang W,Schultz HD

    更新日期:2006-07-01 00:00:00

  • Acute and persistent effects of a 46-kilometer wilderness trail run at altitude: cardiovascular autonomic modulation and baroreflexes.

    abstract:OBJECTIVE:To test the hypothesis that prolonged physical exercise induces long-lasting effects on blood pressure and heart rate we studied 17 endurance runners before and after the 1995 Sandia Wilderness Crossing Research Run (46 km of rocky trails, average altitude 2500 m). METHODS:We evaluated the response of the ca...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bernardi L,Passino C,Robergs R,Appenzeller O

    更新日期:1997-05-01 00:00:00

  • Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells.

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF), secreted by vascular cells and a variety of tumour cells, is a potent angiogenic factor. Since nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells, the aim of the present study was to determine whether VEGF stimulates end...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bouloumié A,Schini-Kerth VB,Busse R

    更新日期:1999-03-01 00:00:00

  • Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.

    abstract:OBJECTIVE:Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on inf...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bowes J,McDonald MC,Piper J,Thiemermann C

    更新日期:1999-01-01 00:00:00

  • VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

    abstract:AIMS:Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify eviden...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Benest AV,Harper SJ,Herttuala SY,Alitalo K,Bates DO

    更新日期:2008-05-01 00:00:00

  • Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation.

    abstract::The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. Both cellular and extracellular factors are involved in the remodeling process and it is th...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Deschamps AM,Spinale FG

    更新日期:2006-02-15 00:00:00

  • End tidal carbon dioxide as an haemodynamic determinant of cardiopulmonary resuscitation in the rat.

    abstract::End tidal PCO2 (PETCO2) has been found to be a good prognostic indicator of successful resuscitation from cardiac arrest. To explore the value of this measurement further, we carried out a series of experiments during cardiac arrest and closed chest resuscitation in 14 mechanically ventilated Sprague-Dawley rats. Vent...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: von Planta M,von Planta I,Weil MH,Bruno S,Bisera J,Rackow EC

    更新日期:1989-04-01 00:00:00

  • Assessment of the functional status of heart failure in non ischemic dilated cardiomyopathy: an echo-dobutamine study.

    abstract:BACKGROUND:The functional status of heart failure (HF) is conventionally evaluated by peak exercise oxygen consumption (VO2 max). Dobutamine echocardiography can be used to evaluate myocardial reserve. The aim of this study was to estimate the functional status of chronic HF in patients with dilated cardiomyopathy, by ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Paraskevaidis IA,Tsiapras DP,Adamopoulos S,Kremastinos DT

    更新日期:1999-07-01 00:00:00

  • The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production.

    abstract:AIMS:The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic disease...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Caillon A,Grenier C,Grimaud L,Vessieres E,Guihot AL,Blanchard S,Lelievre E,Chabbert M,Foucher ED,Jeannin P,Beauvillain C,Abraham P,Loufrani L,Delneste Y,Henrion D

    更新日期:2016-10-01 00:00:00

  • Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel.

    abstract:AIMS:In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase Cepsilon, was shown to modulate the activity of N-ty...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Maturana AD,Wälchli S,Iwata M,Ryser S,Van Lint J,Hoshijima M,Schlegel W,Ikeda Y,Tanizawa K,Kuroda S

    更新日期:2008-06-01 00:00:00

  • Oxygen radical scavenging agents as adjuvant therapy with tissue plasminogen activator in a canine model of coronary thrombolysis.

    abstract:OBJECTIVES:Early thrombolysis can reduce infarct size and enhance the long term recovery of contractile function after acute myocardial infarction. These benefits of early reperfusion may be confounded, however, by platelet mediated reocclusion after initial lysis, and "reperfusion injury" mediated by oxygen derived fr...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Przyklenk K,Kloner RA

    更新日期:1993-06-01 00:00:00

  • PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice.

    abstract:OBJECTIVE:To investigate the physiological role of cAMP-dependent protein kinase A (PKA)-mediated, cardiac myosin binding protein C (MyBP-C) phosphorylation. METHODS:A cardiac MyBP-C cDNA lacking nine amino acids, which contained a phosphorylation site, was made, and subsequently used to generate multiple lines of tra...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Yang Q,Hewett TE,Klevitsky R,Sanbe A,Wang X,Robbins J

    更新日期:2001-07-01 00:00:00

  • Effect of circulation time on plasma high density lipoprotein cholesterol in rats.

    abstract::The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Ishizuka T

    更新日期:1988-05-01 00:00:00

  • Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans.

    abstract:OBJECTIVE:Calcitonin gene related peptide (CGRP) is a potent vasodilator found in sensory nerve endings in coronary arteries. The effect of intravenous CGRP on myocardial ischaemia, cardiovascular haemodynamics, and epicardial coronary artery stenoses was studied in patients with angina to investigate the possible role...

    journal_title:Cardiovascular research

    pub_type: 临床试验,杂志文章


    authors: Uren NG,Seydoux C,Davies GJ

    更新日期:1993-08-01 00:00:00

  • Myocardial oedema: a preventable cause of reperfusion injury?

    abstract::Myocardial ischaemia increases cellular and extracellular osmolarity, alters membrane permeability to ions and causes moderate cell swelling and interstitial oedema. Ischaemia also reduces the mechanical resistance of the sarcolemma of myocytes, probably as a result of proteolytic digestion of the connections between ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Garcia-Dorado D,Oliveras J

    更新日期:1993-09-01 00:00:00

  • Specific non-beta-adrenergic binding sites for 125I-iodocyanopindolol in myocardial membrane preparations: a comparative study between human, rat, and porcine hearts.

    abstract:STUDY OBJECTIVE:The aim was to investigate observed differences in beta adrenergic and apparent non-beta-adrenergic binding of (-)[125I]-iodocyanopindolol (125I-ICYP). DESIGN:Binding parameters for several beta adrenergic agonists and antagonists were examined in radioligand binding assay, using 125I-ICYP as radioliga...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bjørnerheim R,Golf S,Hansson V

    更新日期:1991-09-01 00:00:00

  • Matricellular proteins in the heart: possible role during stress and remodeling.

    abstract::Matricellular proteins are extracellular matrix proteins that modulate cell-matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C (TN-C), tenascin-X (TN-X), osteonectin, osteopontin, thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2). Expression of mat...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Schellings MW,Pinto YM,Heymans S

    更新日期:2004-10-01 00:00:00

  • Remodelling and functional alterations of the rabbit coronary artery in volume overloaded heart.

    abstract:OBJECTIVE:The aim was to study the contractility of the conduit coronary artery to vasoactive agents in developing and established volume overload cardiac hypertrophy and to compare it with structural alterations in the artery. METHODS:Aortic valve insufficiency in rabbits was used to produce a volume overloaded heart...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Gerová M,Holécyová A,Kristek F,Fízel' A,Fízel'ová A

    更新日期:1993-11-01 00:00:00

  • Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs.

    abstract::Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

    更新日期:1975-01-01 00:00:00

  • Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

    abstract:OBJECTIVE:The human ether-a-go-go-related gene (hERG) encodes the rapid component of the cardiac repolarizing delayed rectifier potassium current, I(Kr). The direct interaction of the commonly used protein kinase C (PKC) inhibitor bisindolylmaleimide I (BIM I) with hERG, KvLQT1/minK, and I(Kr) currents was investigated...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Thomas D,Hammerling BC,Wimmer AB,Wu K,Ficker E,Kuryshev YA,Scherer D,Kiehn J,Katus HA,Schoels W,Karle CA

    更新日期:2004-12-01 00:00:00

  • Rate of reflow and reperfusion induced arrhythmias: studies with dual coronary perfusion.

    abstract:OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Ibuki C,Hearse DJ,Avkiran M

    更新日期:1992-04-01 00:00:00

  • Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart.

    abstract:OBJECTIVES:To characterize the 'anti-ischemic' effects of adenosine metabolism inhibition in ischemic-reperfused myocardium. METHODS:Perfused C57/B16 mouse hearts were subjected to 20 min ischemia 40 min reperfusion in the absence or presence of adenosine deaminase inhibition (50 microM erythro-2-(2-hydroxy-3-nonyl)ad...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Peart J,Matherne GP,Cerniway RJ,Headrick JP

    更新日期:2001-10-01 00:00:00

  • Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.

    abstract:OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Hide EJ,Thiemermann C

    更新日期:1996-06-01 00:00:00

  • VEGF administration in chronic myocardial ischemia in pigs.

    abstract:OBJECTIVE:Previous investigations have shown the effectiveness of sustained intra- or extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial ischemia in improvement of left ventricular function. The present investigations were undertaken in order to evaluate efficacy of a single...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Lopez JJ,Laham RJ,Stamler A,Pearlman JD,Bunting S,Kaplan A,Carrozza JP,Sellke FW,Simons M

    更新日期:1998-11-01 00:00:00

  • Nitric oxide regulates vascular calcification by interfering with TGF- signalling.

    abstract:AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Kanno Y,Into T,Lowenstein CJ,Matsushita K

    更新日期:2008-01-01 00:00:00