Binding of [3H]-5-hydroxytryptamine to human coronary artery and bypass graft vessels.

abstract：Aims:Circulating proteins larger than 3 nm can be transported across continuous endothelial barrier of blood vessels via transcytosis. However, excessive accumulation of serum proteins within the vessel walls is uncommon even for those abundant in the circulation. The aim of this study was to investigate how transcytos...

journal_title：Cardiovascular research

authors： Li HY,Liu XL,Liu YT,Jia ZK,Filep JG,Potempa LA,Ji SR,Wu Y

更新日期：2019-02-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium. DESIGN:The suction period preceding the...

journal_title：Cardiovascular research

authors： Boekstegers P,Diebold J,Weiss C

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Growth hormone (GH) is known to induce growth of the normal rat heart. Whether this growth is due solely to hypertrophy of the cardiac myocytes or whether a concomitant hyperplasia of the cardiac myocytes also takes place is currently not known. Therefore, the aim of the present study was to investigate wheth...

journal_title：Cardiovascular research

authors： Brüel A,Christoffersen TE,Nyengaard JR

更新日期：2007-12-01 00:00:00

abstract：:The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved an...

journal_title：Cardiovascular research

authors： Nattel S

更新日期：1998-03-01 00:00:00

abstract：STUDY OBJECTIVE:Protective effects of nipradilol, a newly synthesised vasodilating beta adrenoceptor antagonist, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine were determined by coronary arteriography and compared in vivo in pigs. DESIGN:Acetylc...

journal_title：Cardiovascular research

authors： Kawamura A,Fujiwara H,Ishida M,Takemura G,Kida M,Uegaito T,Tanaka M,Kawai C

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To study the intracellular pathways which mediate the inhibitory actions of adenosine on isoprenaline-stimulated calcium current (ICa) in atrioventricular (AV) nodal myocytes. METHODS:The whole-cell patch-clamp technique was used to record ICa from rabbit AV nodal cells, isolated by enzymatic and mechanical ...

journal_title：Cardiovascular research

authors： Martynyuk AE,Kane KA,Cobbe SM,Rankin AC

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

journal_title：Cardiovascular research

authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the site in the coronary microcirculation that is dilated by an ATP sensitive potassium channel opener, levcromakalim, and to examine whether the magnitude of dilatation is size dependent. METHODS:Coronary arterial microvessels were observed through an intravital microscope equipped wi...

journal_title：Cardiovascular research

authors： Sato K,Kanatsuka H,Sekiguchi N,Akai K,Wang Y,Sugimura A,Kumagai T,Komaru T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：AIMS :Activation of the angiotensin (Ang)-(1-7)/Mas receptor (R) axis protects from sympathetic overactivity. Endocytic trafficking is an essential process that regulates receptor (R) function and its ultimate cellular responses. We investigated whether the blunted responses to Ang-(1-7) in hypertensive rats are associ...

journal_title：Cardiovascular research

authors： Cerniello FM,Silva MG,Carretero OA,Gironacci MM

更新日期：2020-10-01 00:00:00

abstract：:The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this syst...

journal_title：Cardiovascular research

authors： Opie LH,Bricknell OL

更新日期：1979-12-01 00:00:00

abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...

journal_title：Cardiovascular research

authors： Iyoda I,Takahashi H,Lee LC,Okajima H,Inoue A,Sasaki S,Takeda K,Yoshimura M,Ijichi H

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVE:The factors involved in restenosis after balloon angioplasty are poorly characterized but the local concentration of the potent mitogens angiotensin II (AII) and thrombin is known to be increased at sites of vascular injury. We investigated the possibility of a synergistic interaction between AII and thrombin...

journal_title：Cardiovascular research

authors： Fisslthaler B,Schini-Kerth VB,Fleming I,Busse R

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Recently, we have found that rat CMV (RCMV) infected smooth muscle cells (SMCs) in rat carotid arteries when administered 14 days after balloon injury. In the present study we investigated (1) the long term effects of CMV infection on neointimal cross-sectional area, and (2) whether the phenotype of the intim...

journal_title：Cardiovascular research

authors： Persoons MC,Daemen MJ,van Kleef EM,Grauls GE,Wijers E,Bruggeman CA

更新日期：1997-11-01 00:00:00

abstract：AIMS:Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction HFrEF, and to elucidate the underlying mechanisms. METHODS AND RESULT...

journal_title：Cardiovascular research

authors： Røe ÅT,Ruud M,Espe EK,Manfra O,Longobardi S,Aronsen JM,Nordén ES,Husebye T,Kolstad TRS,Cataliotti A,Christensen G,Sejersted OM,Niederer SA,Andersen GØ,Sjaastad I,Louch WE

更新日期：2019-03-15 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:We investigated the influence of experimental hyperlipidemia on the formation of cardiac NO, superoxide, and peroxynitrite (ONOO(-)) in rat hearts. METHODS:Wistar rats were fed 2% cholesterol-enriched diet or normal diet for 8 weeks. Separate groups of normal and hyperlipidemic rats were injected twice intra...

journal_title：Cardiovascular research

authors： Onody A,Csonka C,Giricz Z,Ferdinandy P

更新日期：2003-06-01 00:00:00

abstract：AIMS:17β-Oestradiol (E2) and its receptors (ERα and ERβ) are important regulators of physiological and pathological processes in the cardiovascular system. ER act in concert with other regulatory factors mediating oestrogenic effects. However, the underlying mechanisms modulating ER transcriptional activity are not ful...

journal_title：Cardiovascular research

authors： Mahmoodzadeh S,Pham TH,Kuehne A,Fielitz B,Dworatzek E,Kararigas G,Petrov G,Davidson MM,Regitz-Zagrosek V

更新日期：2012-12-01 00:00:00

abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

journal_title：Cardiovascular research

authors： Zacchigna S,Giacca M

更新日期：2014-05-01 00:00:00

abstract：:Cardiac hypertrophy occurs in a number of disease states associated with chronic increases in cardiac work load. Although cardiac hypertrophy may initially represent an adaptive response of the myocardium, ultimately, it often progresses to ventricular dilatation and heart failure. Much investigation has focused on th...

journal_title：Cardiovascular research

authors： Fiedler B,Wollert KC

更新日期：2004-08-15 00:00:00

abstract：:Major advances in molecular biology over the past decade have increased our understanding of how genes are expressed and regulated in mammalian cells in vivo. This knowledge has been translated to investigations of the molecular and cellular biology of the cardiovascular system. Gene transfer, the introduction of a re...

journal_title：Cardiovascular research

authors： Nabel EG,Pompili VJ,Plautz GE,Nabel GJ

更新日期：1994-04-01 00:00:00

abstract：Aims:The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis and acute coronary syndromes (ACS). However, its role in arterial thrombus formation remains unknown. We investigated whether LOX-1 plays a role in arteria...

journal_title：Cardiovascular research

authors： Akhmedov A,Camici GG,Reiner MF,Bonetti NR,Costantino S,Holy EW,Spescha RD,Stivala S,Schaub Clerigué A,Speer T,Breitenstein A,Manz J,Lohmann C,Paneni F,Beer JH,Lüscher TF

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Some neuropeptides have direct cardiac effects and also modulate the cardiac effects of catecholamines. Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. The aim of this study was to determine the direct and modulatory effects of ...

journal_title：Cardiovascular research

authors： Sun LS,Sawyer WH,Steinberg SF,Rosen MR

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

journal_title：Cardiovascular research

authors： Ibuki C,Hearse DJ,Avkiran M

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:The human ether-a-go-go-related gene (hERG) encodes the rapid component of the cardiac repolarizing delayed rectifier potassium current, I(Kr). The direct interaction of the commonly used protein kinase C (PKC) inhibitor bisindolylmaleimide I (BIM I) with hERG, KvLQT1/minK, and I(Kr) currents was investigated...

journal_title：Cardiovascular research

authors： Thomas D,Hammerling BC,Wimmer AB,Wu K,Ficker E,Kuryshev YA,Scherer D,Kiehn J,Katus HA,Schoels W,Karle CA

更新日期：2004-12-01 00:00:00

abstract：:Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribut...

journal_title：Cardiovascular research

authors： Dormans TP,Pickkers P,Russel FG,Smits P

更新日期：1996-12-01 00:00:00

abstract：:Twenty patients who had suffered myocardial infarction within the previous 3 to 13 days performed face immersion with breath-holding. The maximum reduction in heart rate was 17 +/- 9 beats-min--1 (mean +/- SD). When compared with 24 patients without evidence ischaemic heart disease, they behaved more like younger pati...

journal_title：Cardiovascular research

authors： Gooden BA,Holdstock G,Hampton JR

更新日期：1978-04-01 00:00:00

abstract：:Conventional antithrombotic treatments with antiplatelet, anticoagulant or fibrinolytic drugs are not uniformly successful and are associated with hemorrhagic side effects. Thus, new approaches to the prevention and treatment of arterial thrombosis are desirable. The gene transfer approach is particularly attractive b...

journal_title：Cardiovascular research

authors： Vassalli G,Dichek DA

更新日期：1997-09-01 00:00:00

abstract：AIMS:Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrhythmia development in these patients. To understand the underlying mec...

journal_title：Cardiovascular research

authors： Rathjens FS,Blenkle A,Iyer LM,Renger A,Syeda F,Noack C,Jungmann A,Dewenter M,Toischer K,El-Armouche A,Müller OJ,Fabritz L,Zimmermann WH,Zelarayan LC,Zafeiriou MP

更新日期：2020-08-10 00:00:00

abstract：AIMS:The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the TGFβ-pathway is crucial for this remodelling. Here we tested the hypothesis that microRNAs in the overloaded heart regulate this remodelling process via in...

journal_title：Cardiovascular research

authors： Tijsen AJ,van der Made I,van den Hoogenhof MM,Wijnen WJ,van Deel ED,de Groot NE,Alekseev S,Fluiter K,Schroen B,Goumans MJ,van der Velden J,Duncker DJ,Pinto YM,Creemers EE

更新日期：2014-10-01 00:00:00