Praecordial mapping of Q waves and RS ratio changes in acute myocardial infarction.

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：AIMS:in this study, we attempted to detect a recent myocardial ischaemic event using ultrasound molecular imaging (UMI) with microbubbles (MB) targeted to intercellular adhesion molecule-1 (ICAM-1) in the late phase of reperfusion. METHODS AND RESULTS:we created a myocardial ischaemia-reperfusion model in 60 C57/BL ma...

journal_title：Cardiovascular research

authors： Yan Y,Liao Y,Yang L,Wu J,Du J,Xuan W,Ji L,Huang Q,Liu Y,Bin J

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E-deficient mice (apoE(-/-)) on a regular diet become hypercholesterolemic and develop atherosclerosis, but endothelium-dependent relaxation remains undisturbed for up to 6 months. We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hyperch...

journal_title：Cardiovascular research

authors： Crauwels HM,Van Hove CE,Holvoet P,Herman AG,Bult H

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecular mechanism for and the phosphorylation sites for the enhanced MLC pho...

journal_title：Cardiovascular research

authors： Shimokawa H,Seto M,Katsumata N,Amano M,Kozai T,Yamawaki T,Kuwata K,Kandabashi T,Egashira K,Ikegaki I,Asano T,Kaibuchi K,Takeshita A

更新日期：1999-09-01 00:00:00

abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

journal_title：Cardiovascular research

authors： Olsson SB,Harper R,Rydén L,Hilmy WA

更新日期：1975-09-01 00:00:00

abstract：:Zero drift may be a cause of imprecision when micromanometer tipped catheters are used for intravascular pressure measurement over long periods of time. Drift of only a few mm Hg may represent a significant error when accurate recording of low vascular pressures is required. To overcome this problem a micromanometer t...

journal_title：Cardiovascular research

authors： Gibbs JS,Cunningham D,Sparrow J,Poole-Wilson PA,Fox KM

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogeno...

journal_title：Cardiovascular research

authors： Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DM

更新日期：1980-02-01 00:00:00

abstract：:Isolated, buffer perfused guinea pig hearts were used to study the effects of sotalol on arrhythmias and electrophysiology during 30 min of myocardial ischaemia, induced by reducing coronary flow to 10% of control, and subsequent reperfusion. Action potentials were recorded using the floating microelectrode technique ...

journal_title：Cardiovascular research

authors： Culling W,Penny WJ,Sheridan DJ

更新日期：1984-07-01 00:00:00

abstract：:The efficacy of cardioprotective strategies can be quantified by myocardial salvage as an indicator of therapeutic benefit. Salvage is calculated as the difference between the area at risk (AAR) and the final infarct size (FIS). AAR has been quantified by angiographic assessment followed by quantification of FIS by bi...

journal_title：Cardiovascular research

authors： Bøtker HE,Kaltoft AK,Pedersen SF,Kim WY

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transg...

journal_title：Cardiovascular research

authors： Maier LS,Wahl-Schott C,Horn W,Weichert S,Pagel C,Wagner S,Dybkova N,Müller OJ,Näbauer M,Franz WM,Pieske B

更新日期：2005-09-01 00:00:00

abstract：:Postextrasystolic potentiation was studied by means of a catheter-tip manometer in patients with and without cardiomyopathy. The results imply that the enhancement of the left ventricular contraction is increased in patients with cardiomyopathy. ...

journal_title：Cardiovascular research

authors： Kvasnicka J,Liander B,Broman H,Varnauskas E

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether alpha 1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the ne...

journal_title：Cardiovascular research

authors： van Kleef EM,Smits JF,Schwartz SM,Daemen MJ

更新日期：1996-02-01 00:00:00

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Angiotensin II stimulates vascular smooth muscle cell (VSMC) growth, and is considered to be an important mediator of intimal thickening after vascular injury. Recent evidence has indicated that VSMC apoptosis plays a major role in the response to balloon injury, and we therefore examined the effect of angiot...

journal_title：Cardiovascular research

authors： Holm AM,Andersen CB,Haunsø S,Hansen PR

更新日期：2000-02-01 00:00:00

abstract：:To define the interactions between blood and endocardium damaged by lactic acid, the left ventricles of 48 isolated continuously perfused and beating hearts were exposed for 0-4 hours to Krebs Henseleit buffer (KHB) with or without 33 mumol.ml-1 of lactic acid (pH 6.4). After excising its apex, the left ventricle was ...

journal_title：Cardiovascular research

authors： Carter G,Gavin JB

更新日期：1989-06-01 00:00:00

abstract：AIMS:Our aim was to determine whether the repeated, binge administration of 3,4-methylenedioxymethamphetamine (ecstasy; MDMA) produces structural and/or functional changes in the myocardium that are associated with oxidative stress. METHODS AND RESULTS:Echocardiography and pressure-volume conductance catheters were us...

journal_title：Cardiovascular research

authors： Shenouda SK,Lord KC,McIlwain E,Lucchesi PA,Varner KJ

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...

journal_title：Cardiovascular research

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Nadeau R

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:The adhesive interaction of monocytes and endothelial cells has been implicated as a regulatory signal in the cell activation that is involved in the pathogenesis of atherosclerosis. We investigated the effect of monocyte-endothelial cell interaction on the expression of adhesion molecules, intercellular adhe...

journal_title：Cardiovascular research

authors： Takahashi M,Ikeda U,Masuyama J,Kitagawa S,Kasahara T,Shimpo M,Kano S,Shimada K

更新日期：1996-08-01 00:00:00

abstract：AIM:Clinical use of amiodarone is associated with occasional development of torsade de pointes (TdP). However, preclinical models have failed to demonstrate the proarrhythmic potential of amiodarone. The objective of this study was to reveal and explain the pro- and anti-arrhythmic effects of acute exposure to amiodaro...

journal_title：Cardiovascular research

authors： Wu L,Rajamani S,Shryock JC,Li H,Ruskin J,Antzelevitch C,Belardinelli L

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:In several cell types, proteasome inhibitors like carbobenzoxyl-leucinyl-leucinyl-leucinal (MG132) induce the 72 kDa heat shock protein (Hsp72) and exert cell protective effects. However, data in cardiomyocytes are currently lacking. METHODS AND RESULTS:We investigated the effects of MG132 in cultured neonat...

journal_title：Cardiovascular research

authors： Lüss H,Schmitz W,Neumann J

更新日期：2002-04-01 00:00:00

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:We performed the following study to define the effects of acute cardiac lymphatic obstruction on left ventricular (LV) systolic and diastolic function. METHODS:Cardiac lymphatic obstruction was created in 8 pentobarbital-anesthetized dogs by identifying (Evans blue) and ligating the right and left epicardia...

journal_title：Cardiovascular research

authors： Ludwig LL,Schertel ER,Pratt JW,McClure DE,Ying AJ,Heck CF,Myerowitz PD

更新日期：1997-01-01 00:00:00

abstract：:A pulsed, range gated, directional, ultrasonic, Doppler blood velocity meter was used to record signals from the pulmonary artery in 52 normal subjects ranging in age from less than 1 week to over 30 years. Signals were obtained from an unfocused transducer in the second or third left intercostal space using a 2.25 MH...

journal_title：Cardiovascular research

authors： Targett RC,Heldt GP,McIlroy MB

更新日期：1986-11-01 00:00:00

abstract：AIMS:Polyunsaturated fatty n-3 acids (PUFAs) have been reported to exhibit antiarrhythmic properties. However, the mechanisms of action remain unclear. We studied the electrophysiological effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on IKs, and on the expression and location of Kv7.1 and KCNE1....

journal_title：Cardiovascular research

authors： Moreno C,de la Cruz A,Oliveras A,Kharche SR,Guizy M,Comes N,Starý T,Ronchi C,Rocchetti M,Baró I,Loussouarn G,Zaza A,Severi S,Felipe A,Valenzuela C

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death. METHODS:Isolated arterially perfused rabbit papillary muscles and septa were suspended in a control...

journal_title：Cardiovascular research

authors： Kaplan SH,Yang H,Gilliam DE,Shen J,Lemasters JJ,Cascio WE

更新日期：1995-02-01 00:00:00

abstract：AIMS:This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart. METHODS AND RESULTS:The expression of the Gjb6 gene in the mouse heart was investigated by RT-PCR and sequencing of amplified cDNA fragments. The sites of Gjb6...

journal_title：Cardiovascular research

authors： Gros D,Théveniau-Ruissy M,Bernard M,Calmels T,Kober F,Söhl G,Willecke K,Nargeot J,Jongsma HJ,Mangoni ME

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Atrial remodeling contributes to the maintenance of atrial fibrillation (AF) in several cardiac disorders. There is evidence that angiotensin-converting enzyme (ACE) inhibitors reduce the prevalence of AF in patients with congestive heart failure (CHF). There have been no studies performed to assess the effec...

journal_title：Cardiovascular research

authors： Shi Y,Li D,Tardif JC,Nattel S

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes. METHODS:The whole cell patch clamp technique was used to record action potentials, the effective r...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2001-11-01 00:00:00