The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation.

abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF), which plays a pivotal role in the control of inflammatory responses, was first characterized as a T-cell cytokine, but later was also found as a pituitary peptide released in response to infection and stress. However, MIF's role and expression in the myocardium ha...

journal_title：Cardiovascular research

authors： Takahashi M,Nishihira J,Shimpo M,Mizue Y,Ueno S,Mano H,Kobayashi E,Ikeda U,Shimada K

更新日期：2001-12-01 00:00:00

abstract：AIMS:GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload...

journal_title：Cardiovascular research

authors： Han M,Yang Z,Sayed D,He M,Gao S,Lin L,Yoon S,Abdellatif M

更新日期：2012-03-15 00:00:00

abstract：OBJECTIVE:Sepsis-stimulated nitric oxide (NO) production impairs arteriolar responsiveness in skeletal muscle. Using wild type (WT), eNOS(-/-), iNOS(-/-) and nNOS(-/-) mice, we aimed to determine the key nitric oxide synthase (NOS) isoenzyme(s) responsible for the arteriolar hyporesponsiveness to acetylcholine (ACh) in...

journal_title：Cardiovascular research

authors： Lidington D,Li F,Tyml K

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect of increased left ventricular filling pressure on the pulmonary vein flow (PVQ) pattern. METHODS:Pulmonary vein flow was recorded using an ultrasonic transit time flow meter in six anaesthetised dogs. Mean left atrial pressure was increased by stepwise volume loading fro...

journal_title：Cardiovascular research

authors： Smiseth OA,Lødemel K,Riddervold F,Blaha M

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the ionic basis of action potential lengthening associated with cardiac hypertrophy. METHODS:Action potentials and ionic currents of left ventricular myocytes isolated from normal and hypertrophied hearts were recorded with patch pipettes. Since cardiac hypertrophy is a time dependen...

journal_title：Cardiovascular research

authors： Cerbai E,Barbieri M,Li Q,Mugelli A

更新日期：1994-08-01 00:00:00

abstract：:The theory related to the loss of R waves and appearance of Q waves in acute myocardial infarction is discussed. A method of praecordial mapping of RS ratio changes and the appearance of Q waves that occur in acute myocardial infarction is described. The serial changes in these electrocardiographic signs in 17 patient...

journal_title：Cardiovascular research

authors： Selwyn AP,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00

abstract：:The effect of axial rotation on flow through and pressure gradient across saphenous vein segments was studied using 15 cadaver long saphenous veins. A significant reduction in flow occurred at a mean rotation of 25 degrees/cm and a significant increase in head loss across the segments occurred at a mean rotation of 23...

journal_title：Cardiovascular research

authors： Gordon A,Williams J,Buxton B

更新日期：1975-07-01 00:00:00

abstract：AIMS:Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR). RyR type 1 or type 2 was prepared from rabbit skeletal muscle or pig cardiac muscle, respectively. In heart failure,...

journal_title：Cardiovascular research

authors： Blayney LM,Jones JL,Griffiths J,Lai FA

更新日期：2010-01-01 00:00:00

abstract：AIMS:To determine the role of gap junctions (GJs) in hypoxic pulmonary vasoconstriction (HPV). METHODS AND RESULTS:Studies were performed in rat isolated intrapulmonary arteries (IPAs) mounted on a myograph and in anaesthetized rats. Hypoxia induced a biphasic HPV response in IPAs preconstricted with prostaglandin F2α...

journal_title：Cardiovascular research

authors： Kizub IV,Strielkov IV,Shaifta Y,Becker S,Prieto-Lloret J,Snetkov VA,Soloviev AI,Aaronson PI,Ward JP

更新日期：2013-08-01 00:00:00

abstract：:The cardiac mechano- and chemoreceptors are broadly distributed in the myocardium and coronary vessels. A portion of these receptors extends over the epicardium and pericardium and therefore can be excited by mechanical or chemical stimuli directly applied to the surface of the heart. Excitation of epicardial receptor...

journal_title：Cardiovascular research

authors： Cinca J,Rodríguez-Sinovas A

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS:Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, ...

journal_title：Cardiovascular research

authors： Jerkic M,Rodríguez-Barbero A,Prieto M,Toporsian M,Pericacho M,Rivas-Elena JV,Obreo J,Wang A,Pérez-Barriocanal F,Arévalo M,Bernabéu C,Letarte M,López-Novoa JM

更新日期：2006-03-01 00:00:00

abstract：:In pulmonary arterial hypertension (PAH), right ventricular (RV) adaptation is essential to overcome the chronic increases in RV pressure overload. Ultimately, RV compensatory mechanisms are not sufficient and patients succumb to RV failure. The processes underlying the transition of RV adaptation to RV failure are no...

journal_title：Cardiovascular research

authors： van der Bruggen CEE,Tedford RJ,Handoko ML,van der Velden J,de Man FS

更新日期：2017-10-01 00:00:00

abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

journal_title：Cardiovascular research

authors： Sawanobori T,Hirano Y,Hiraoka M

更新日期：1987-11-01 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：AIMS:Moderate wine consumption is associated with a significant reduction of cardiovascular mortality. The molecular basis of this phenomenon remains unknown. Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor ...

journal_title：Cardiovascular research

authors： Sparwel J,Vantler M,Caglayan E,Kappert K,Fries JW,Dietrich H,Böhm M,Erdmann E,Rosenkranz S

更新日期：2009-03-01 00:00:00

abstract：:Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are...

journal_title：Cardiovascular research

authors： Dubey RK,Oparil S,Imthurn B,Jackson EK

更新日期：2002-02-15 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Some neuropeptides have direct cardiac effects and also modulate the cardiac effects of catecholamines. Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. The aim of this study was to determine the direct and modulatory effects of ...

journal_title：Cardiovascular research

authors： Sun LS,Sawyer WH,Steinberg SF,Rosen MR

更新日期：1993-09-01 00:00:00

abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

journal_title：Cardiovascular research

authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Conduction of vasoconstrictor and vasodilator responses in the microcirculation involves electrical coupling through gap junction channels among cells of the vascular wall. The present study determined whether reported differences in the properties of conduction along the arterioles of the epithelial hamster...

journal_title：Cardiovascular research

authors： Sandow SL,Looft-Wilson R,Doran B,Grayson TH,Segal SS,Hill CE

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Recent studies indicate that endothelial type nitric oxide synthase (NOS3) modulates cardiac systolic and diastolic function and the inotropic responsiveness to beta-adrenergic agonists, and may affect myocardial oxygen consumption. Although NOS3 is a constitutive protein, its levels of expression can be modi...

journal_title：Cardiovascular research

authors： Bayraktutan U,Yang ZK,Shah AM

更新日期：1998-06-01 00:00:00

abstract：:The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and funct...

journal_title：Cardiovascular research

authors： Penela P,Murga C,Ribas C,Tutor AS,Peregrín S,Mayor F Jr

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Heme oxygenases (HO) are the rate-limiting enzymes in heme degradation, catalyzing the breakdown of heme to equimolar quantities of biliverdin (BV), carbon monoxide (CO), and ferrous iron. The inducible HO isoform, HO-1, confers protection against ischemia/reperfusion (I/R)-injury in the heart. We hypothesize...

journal_title：Cardiovascular research

authors： Tongers J,Fiedler B,König D,Kempf T,Klein G,Heineke J,Kraft T,Gambaryan S,Lohmann SM,Drexler H,Wollert KC

更新日期：2004-08-15 00:00:00

abstract：OBJECTIVE:We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertr...

journal_title：Cardiovascular research

authors： Ha T,Li Y,Hua F,Ma J,Gao X,Kelley J,Zhao A,Haddad GE,Williams DL,William Browder I,Kao RL,Li C

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:The aims were: (1) to evaluate whether differences in absolute and cyclic echocardiographic image amplitude exist in different layers (subendocardium and subepicardium) and regions (septal, anterior, lateral, inferior wall) of the canine left ventricle; (2) to assess the dependence of these variables upon loc...

journal_title：Cardiovascular research

authors： Marini C,Ghelardini G,Picano E,Rovai D,Lombardi M,Trivella MG,Distante A,L'Abbate A

更新日期：1993-02-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate observed differences in beta adrenergic and apparent non-beta-adrenergic binding of (-)[125I]-iodocyanopindolol (125I-ICYP). DESIGN:Binding parameters for several beta adrenergic agonists and antagonists were examined in radioligand binding assay, using 125I-ICYP as radioliga...

journal_title：Cardiovascular research

authors： Bjørnerheim R,Golf S,Hansson V

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:The aim was to determine the effect and mechanisms by which myocyte stretch interacts with the prolongation of action potential duration (APD) by the class III antiarrhythmic agent E-4031. METHODS:Action potentials and whole-cell currents were measured in isolated guinea pig ventricular myocytes with a patc...

journal_title：Cardiovascular research

authors： Groh WJ,Gibson KJ,Maylie JG

更新日期：1996-02-01 00:00:00