Abstract:
:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogenous noradrenaline (NA). Contractile response was measured with intramyocardial sonomicrometers. LSS increased aortic pressure and heart rate. NA was infused to achieve an aortic pressure equivalent to LSS and simultaneous atrial pacing matched the heart rate during LSS. In normal zones both interventions produced increased shortening equivalently. In ischaemic zones systolic expansion was unchanged during LSS, while NA improved contractile function of the same zones by decreasing systolic expansion. These responses occurred during ischaemia produced by either anterior or posterior descending coronary occlusion. Changes in regional blood flow, measured by 8 microns radiolabelled microspheres, could not account for the difference between the ischaemic regional response to LSS or NA. We conclude that acute regional ischaemia impairs adrenergic nerve transmission.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DMdoi
10.1093/cvr/14.2.116subject
Has Abstractpub_date
1980-02-01 00:00:00pages
116-24issue
2eissn
0008-6363issn
1755-3245journal_volume
14pub_type
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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doi:10.1093/cvr/27.12.2205
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journal_title:Cardiovascular research
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doi:10.1093/cvr/19.5.270
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1093/cvr/cvr078
更新日期:2011-07-15 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvn140
更新日期:2008-09-01 00:00:00
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doi:10.1093/cvr/28.10.1586
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(97)00222-8
更新日期:1998-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvaa171
更新日期:2020-07-15 00:00:00
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journal_title:Cardiovascular research
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更新日期:1983-06-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2003-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvt001
更新日期:2013-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2006.09.014
更新日期:2007-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00703-4
更新日期:2003-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/10.1.13
更新日期:1976-01-01 00:00:00
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doi:10.1093/cvr/9.4.515
更新日期:1975-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvw083
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/cvr/cvr345
更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2000-01-14 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/25.10.875
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2007-11-01 00:00:00
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更新日期:2021-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(01)00536-3
更新日期:2002-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvp382
更新日期:2010-04-01 00:00:00