Ecstasy produces left ventricular dysfunction and oxidative stress in rats.

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:It has been proposed that human immunodeficiency virus (HIV) infection-induced inflammatory environment may contribute to the pathogenesis of cardiovascular diseases. Recent studies have also demonstrated the potential role of estrogen as therapeutic agents in the prevention or treatment of cardiovascular dis...

journal_title：Cardiovascular research

authors： Lee YW,Eum SY,Nath A,Toborek M

更新日期：2004-07-01 00:00:00

abstract：:Elevated sympathetic activity changes renal function and accelerates the development of hypertension. Principles of sympatho-renal interactions in chronic hypertension are reviewed. Alterations in the ontogeny of the sympathetic nervous system and the kidney, inherited abnormalities in sensory receptor function and ex...

journal_title：Cardiovascular research

authors： Grisk O,Rettig R

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

journal_title：Cardiovascular research

authors： Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

更新日期：1999-11-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium. DESIGN:The suction period preceding the...

journal_title：Cardiovascular research

authors： Boekstegers P,Diebold J,Weiss C

更新日期：1990-06-01 00:00:00

abstract：:This study has investigated the origin of the pulsatile expansion of the forearm recorded by the amplification of the pulsatile signal derived from a mercury in rubber plethysmograph. Venous occlusion to pressures of 40 mmHg had no effect on the amplitude of the volume pulse, suggesting that the volume pulse originate...

journal_title：Cardiovascular research

authors： Fitchett DH

更新日期：1984-11-01 00:00:00

abstract：:In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. The use of LTCC Ca(2+) as a multi-dimensional signalling molecule in the heart is complicated by several aspects of ...

journal_title：Cardiovascular research

authors： Shaw RM,Colecraft HM

更新日期：2013-05-01 00:00:00

abstract：AIMS:Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach. METHODS AND RESULTS:Mice ...

journal_title：Cardiovascular research

authors： Unsöld B,Kaul A,Sbroggiò M,Schubert C,Regitz-Zagrosek V,Brancaccio M,Damilano F,Hirsch E,Van Bilsen M,Munts C,Sipido K,Bito V,Detre E,Wagner NM,Schäfer K,Seidler T,Vogt J,Neef S,Bleckmann A,Maier LS,Balligand JL,

更新日期：2014-01-01 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that chronic cardiac denervation impairs myocardial glucose oxidation. To investigate this further we tested whether the tissue content of glucose transporters, activity of glycolytic enzymes or metabolic capacity of pyruvate dehydrogenase were altered. Moreover, we investigated wh...

journal_title：Cardiovascular research

authors： van der Vusse GJ,Dubelaar ML,Coumans WA,Seymour AM,Clarke SB,Bonen A,Drake-Holland AJ,Noble MI

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Atrial (ANP) and B-type natriuretics peptides (BNP) via their guanylyl cyclase-A (GC-A) receptor not only regulate arterial blood pressure and volume but also exert local antihypertrophic, antifibrotic and lusitropic effects in the heart. To elucidate whether cardiac hypertrophy/insufficiency and reversal is ...

journal_title：Cardiovascular research

authors： Kuhn M,Voss M,Mitko D,Stypmann J,Schmid C,Kawaguchi N,Grabellus F,Baba HA

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:At present little is known about the factors that regulate the expression of the endothelins and their receptors in cardiac tissue in vivo. The aim of this study was to investigate changes in expression of the endothelins (ET-1, ET-2, and ET-3) and their receptors (ETAR and ETBR) in the hypertrophied heart of...

journal_title：Cardiovascular research

authors： Brown LA,Nunez DJ,Brookes CI,Wilkins MR

更新日期：1995-06-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) attenuates neutrophil (PMN)-mediated damage, partly by inhibiting superoxide anion (O2-) generation and adherence to the coronary artery endothelium. L-Arginine is the endogenous substrate for production of NO via the NO synthase pathway. This study tested the hypothesis that the endogenous...

journal_title：Cardiovascular research

authors： Sato H,Zhao ZQ,Vinten-Johansen J

更新日期：1996-01-01 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias. METHODS:Nicotinic, muscarinic, beta adrenergic, peptidergic, and amino acidergic agonists, as well as purinergic compounds, were individually administered in microliter quantities adjacent...

journal_title：Cardiovascular research

authors： Huang MH,Wolf SG,Armour JA

更新日期：1994-05-01 00:00:00

abstract：:The cardioprotective effects of mioflazine, a recently developed cardiovascular drug, were investigated in 41 anaesthetised open chest Beagle dogs subjected to 1 h normothermic global myocardial ischaemia. The severity of the model is evidenced by the finding that only one out of 20 control dogs could be weaned from e...

journal_title：Cardiovascular research

authors： Flameng W,Xhonneux R,Van Belle H,Borgers M,Van de Water A,Wouters L,Wijnants J,Thoné F,Van Daele P,Janssen PA

更新日期：1984-09-01 00:00:00

abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...

journal_title：Cardiovascular research

authors： Burris JF,Waeber B,Brunner HR

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from the sarcoplasmic reticulum. METHODS:Isometric force of postrest contrac...

journal_title：Cardiovascular research

authors： Komai H,Rusy BF

更新日期：1993-05-01 00:00:00

abstract：AIMS:It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart. However, the involvement of voltage-insensitive cationic TRPC (transient receptor potential canonical) channels remains unclear. We assessed the hypothesis tha...

journal_title：Cardiovascular research

authors： Sabourin J,Robin E,Raddatz E

更新日期：2011-11-01 00:00:00

abstract：AIMS:Extracellular nucleotides are vasoactive molecules. The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice. METHODS AND RESULTS:Immunofluore...

journal_title：Cardiovascular research

authors： Kauffenstein G,Drouin A,Thorin-Trescases N,Bachelard H,Robaye B,D'Orléans-Juste P,Marceau F,Thorin E,Sévigny J

更新日期：2010-01-01 00:00:00

abstract：AIMS:GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload...

journal_title：Cardiovascular research

authors： Han M,Yang Z,Sayed D,He M,Gao S,Lin L,Yoon S,Abdellatif M

更新日期：2012-03-15 00:00:00

abstract：AIMS:Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, the cellular and molecular mechanisms of platelet-dependent angiogenesis, especially the involvement of TP signallin...

journal_title：Cardiovascular research

authors： Amano H,Ito Y,Eshima K,Kato S,Ogawa F,Hosono K,Oba K,Tamaki H,Sakagami H,Shibuya M,Narumiya S,Majima M

更新日期：2015-09-01 00:00:00

abstract：AIMS:Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify eviden...

journal_title：Cardiovascular research

authors： Benest AV,Harper SJ,Herttuala SY,Alitalo K,Bates DO

更新日期：2008-05-01 00:00:00

abstract：:Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue devi...

journal_title：Cardiovascular research

authors： Lab MJ,Gartside I,Wassermann S

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:The aim was to study the effect of thyroid hormone on collagen gene expression in the myocardium of the tight skin mouse (TSK), a genetic model of myocardial fibrosis. METHODS:Heterozygous male (TSK/+) (n = 20) and normal (+/+) homozygous mice (n = 20), 1.5-2 months old of the C57 BL/6 strain were studied. V...

journal_title：Cardiovascular research

authors： Yao J,Eghbali M

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the anaesthetised dog. METHODS:Heparin or N-acetylheparin was given in three repeated intravenous doses of 2 mg.kg-1. Drug or...

journal_title：Cardiovascular research

authors： Black SC,Gralinski MR,Friedrichs GS,Kilgore KS,Driscoll EM,Lucchesi BR

更新日期：1995-05-01 00:00:00

abstract：:As the developing heart grows and the chamber walls thicken, passive diffusion of oxygen and nutrients is replaced by a vascular plexus which remodels and expands to form a mature coronary vascular system. The coronary arteries and veins ensure the continued development of the heart and facilitate cardiac output with ...

journal_title：Cardiovascular research

authors： Riley PR,Smart N

更新日期：2011-07-15 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：AIMS:Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. METHODS AND RESULTS:Forty Large-White pigs were included. In Study 1...

journal_title：Cardiovascular research

authors： Galán-Arriola C,Villena-Gutiérrez R,Higuero-Verdejo MI,Díaz-Rengifo IA,Pizarro G,López GJ,de Molina-Iracheta A,Pérez-Martínez C,García RD,González-Calle D,Lobo M,Sánchez PL,Oliver E,Córdoba R,Fuster V,Sánchez-González J,I

更新日期：2020-06-29 00:00:00