VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

Abstract:

AIMS:Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify evidence of polarized growth of lymphatics driven by specialized cells at the tip of the growing sprout. METHODS AND RESULTS:We used an adult model of lymphangiogenesis in the rat mesentery. The angiogenic effect of VEGF-C was markedly attenuated in the presence of a growing lymphatic network. Furthermore, we show that this growth of lymphatic vessels can occur both by recruitment of isolated lymphatic islands to a connected network and by filopodial sprouting. The latter is independent of polarized tip cell differentiation that can be generated all along lymphatic capillaries, independently of the proliferation status of the lymphatic endothelial cells. CONCLUSION:These results both demonstrate a dependence of VEGF-C-mediated angiogenesis on lymphatic vascular networks and indicate that the mechanism of VEGF-C-mediated lymphangiogenesis is different from that of classical angiogenic mechanisms.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Benest AV,Harper SJ,Herttuala SY,Alitalo K,Bates DO

doi

10.1093/cvr/cvm094

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

315-23

issue

2

eissn

0008-6363

issn

1755-3245

pii

cvm094

journal_volume

78

pub_type

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