Cardiac mass in glucocorticoid-hypertensive rats with and without circulating adrenaline.

abstract：AIMS:Human C-peptide has a beneficial effect on the prevention of diabetic neuropathy, nephropathy, and vascular complications; however, its role in protection against increased vascular permeability in diabetes remains unclear. Our purpose was to explore the potential protective role of C-peptide against microvascular...

journal_title：Cardiovascular research

authors： Lim YC,Bhatt MP,Kwon MH,Park D,Lee S,Choe J,Hwang J,Kim YM,Ha KS

更新日期：2014-01-01 00:00:00

abstract：:Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate clearly have robust NO-like effects in humans, including blood pressure reduction, inhibition of platelet aggregation, and vasoprot...

journal_title：Cardiovascular research

authors： Lundberg JO,Carlström M,Larsen FJ,Weitzberg E

更新日期：2011-02-15 00:00:00

abstract：:A growing body of animal studies provides evidence for potential cardioprotective effects of inhibitors of the enzyme phosphodiesterase isoform 5. Infarct size reduction by administration of phosphodiesterase 5 inhibitors was described in various experimental models of ischaemia and reperfusion. Furthermore, potential...

journal_title：Cardiovascular research

authors： Reffelmann T,Kloner RA

更新日期：2009-07-15 00:00:00

abstract：AIMS:Mobilization of stem cells/progenitors is regulated by the interaction between stromal cell-derived factor-1 (SDF-1) and its ligand, CXC chemokine receptor 4 (CXCR4). Statins have been suggested to ameliorate pulmonary arterial hypertension (PAH); however, the mechanisms involved, especially their effects on proge...

journal_title：Cardiovascular research

authors： Satoh K,Fukumoto Y,Nakano M,Sugimura K,Nawata J,Demachi J,Karibe A,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2009-01-01 00:00:00

abstract：:Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking...

journal_title：Cardiovascular research

authors： Apostolakis S,Vogiatzi K,Amanatidou V,Spandidos DA

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) opening at reperfusion. METHODS:Isolated rat hearts were subjected to 35 min ischemia/120 min reperfusion and assigned to the follo...

journal_title：Cardiovascular research

authors： Hausenloy DJ,Maddock HL,Baxter GF,Yellon DM

更新日期：2002-08-15 00:00:00

abstract：AIMS:Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dep...

journal_title：Cardiovascular research

authors： Boisguérin P,Covinhes A,Gallot L,Barrère C,Vincent A,Busson M,Piot C,Nargeot J,Lebleu B,Barrère-Lemaire S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect of lowering external potassium on the sensitivity of the normal and hypertrophied rat heart to arrhythmias induced by increases in ventricular wall stress. METHODS:The isolated working heart model was used to compare hypertrophied hearts from the spontaneously hypertensi...

journal_title：Cardiovascular research

authors： Evans SJ,Levi AJ,Jones JV

更新日期：1995-04-01 00:00:00

abstract：AIMS:Recent publications have shed new light on the role of the adaptive and innate immune system in the pathogenesis of hypertension. However, there are limited data whether receptors of the innate immune system may influence blood pressure. Toll-like receptor 4 (TLR4), a pattern recognition receptor, is a key compone...

journal_title：Cardiovascular research

authors： Sollinger D,Eißler R,Lorenz S,Strand S,Chmielewski S,Aoqui C,Schmaderer C,Bluyssen H,Zicha J,Witzke O,Scherer E,Lutz J,Heemann U,Baumann M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Oxidized low-density lipoproteins (ox-LDL) or their components suppress macrophage inflammatory response by down-regulating cytokine synthesis, nitric oxide synthase and inducible cyclooxygenase (Cox-2). This event is crucial for the pathophysiological process leading to the formation of atherosclerotic plaqu...

journal_title：Cardiovascular research

authors： Eligini S,Brambilla M,Banfi C,Camera M,Sironi L,Barbieri SS,Auwerx J,Tremoli E,Colli S

更新日期：2002-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:Previous investigations have shown the effectiveness of sustained intra- or extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial ischemia in improvement of left ventricular function. The present investigations were undertaken in order to evaluate efficacy of a single...

journal_title：Cardiovascular research

authors： Lopez JJ,Laham RJ,Stamler A,Pearlman JD,Bunting S,Kaplan A,Carrozza JP,Sellke FW,Simons M

更新日期：1998-11-01 00:00:00

abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

journal_title：Cardiovascular research

authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

更新日期：2014-07-01 00:00:00

abstract：:Arteriogenesis, the process of collateral artery growth as an adaptation to major arterial occlusion, can be life- and tissue saving and may alter the natural course of the consequences and organ manifestations of arterial disease. This is achieved by an active growth process that is coupled to complete arterial remod...

journal_title：Cardiovascular research

authors： Schaper W,Buschmann I

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

journal_title：Cardiovascular research

authors： Ibuki C,Hearse DJ,Avkiran M

更新日期：1992-04-01 00:00:00

abstract：Aims:To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results:Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well a...

journal_title：Cardiovascular research

authors： Zhang C,Chen D,Maguire EM,He S,Chen J,An W,Yang M,Afzal TA,Luong LA,Zhang L,Lei H,Wu Q,Xiao Q

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The regulation of pulmonary prostacyclin synthesis is not completely understood. We tested the hypothesis that prostacyclin production is predominantly stimulated by hemodynamic factors, such as increased shear-stress, and is thus increased in rats with chronic hypoxic pulmonary hypertension. METHODS:To this...

journal_title：Cardiovascular research

authors： Blumberg FC,Lorenz C,Wolf K,Sandner P,Riegger GA,Pfeifer M

更新日期：2002-07-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：AIMS:Herpes virus entry mediator (HVEM) is considered to be a molecular 'switch' for immune responses, and a role in immune modification has been reported. The aim of this study was to assess whether HVEM-mediated immune suppression could protect against experimental autoimmune myocarditis (EAM) induced by myosin. MET...

journal_title：Cardiovascular research

authors： Cai G,Wang H,Qin Q,Zhang J,Zhu Z,Liu M,Shen Q

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Research in the pathophysiology of ischemia/reperfusion or redox signaling is hindered by lack of simple methodology to measure short-lived oxygen radicals. In the presence of hydroxyl radical ((*)OH), d-phenylalanine (d-Phe) yields para-, meta- and ortho-tyrosine. We have previously demonstrated that d-Phe c...

journal_title：Cardiovascular research

authors： Biondi R,Ambrosio G,Liebgott T,Cardounel AJ,Bettini M,Tritto I,Zweier JL

更新日期：2006-07-15 00:00:00

abstract：:Atrial fibrillation (AF) is the most common tachyarrhythmia in clinical practice. Over decades of research, a vast amount of knowledge has been gathered about the causes and consequences of AF related to cellular electrophysiology and features of the tissue structure that influence the propagation of fibrillation wave...

journal_title：Cardiovascular research

authors： Opacic D,van Bragt KA,Nasrallah HM,Schotten U,Verheule S

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Epidemiological evidence in humans suggests that intrauterine growth retardation is associated with an increased risk of hypertension and coronary heart disease in later life. To begin to understand the mechanisms involved, we developed and exploited a rat model of intrauterine growth retardation to assess p...

journal_title：Cardiovascular research

authors： Hu XW,Levy A,Hart EJ,Nolan LA,Dalton GR,Levi AJ

更新日期：2000-11-01 00:00:00

abstract：:End-diastolic current thresholds have been measured in 12 open-chested dogs with epicardial disc electrodes ranging in radius from 0.01 to 9.0 mm. The current threshold for cathodal 1 ms impulses proved to be independent of electrode size for radii smaller than 0.2 mm and proportional to the radius to the power 1.5 fo...

journal_title：Cardiovascular research

authors： Lindemans FW,Denier Van der Gon JJ

更新日期：1978-08-01 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

journal_title：Cardiovascular research

authors： Zacchigna S,Giacca M

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effects of a calcium antagonist (diltiazem) and a catecholamine (noradrenaline) on extracellular potassium accumulation during global ischaemia. METHODS:Extracellular potassium concentration ([K+]e) was measured during 30 min global ischaemia in the isolated rat heart using a v...

journal_title：Cardiovascular research

authors： Mitani A,Kinoshita K,Fukamachi K,Sakamoto M,Kurisu K,Fukumura F,Tsuruhara Y,Nakashima A,Tokunaga K

更新日期：1992-11-01 00:00:00

abstract：:The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. Both cellular and extracellular factors are involved in the remodeling process and it is th...

journal_title：Cardiovascular research

authors： Deschamps AM,Spinale FG

更新日期：2006-02-15 00:00:00

abstract：:The effect of catheterisation on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheter...

journal_title：Cardiovascular research

authors： Madsen JK,Garbarsch C,Nielsen PE

更新日期：1979-09-01 00:00:00

abstract：:To determine the effect of an anteroseptal myocardial infarction on right ventricular systolic and diastolic function, we studied 12 pigs before and 1 h after left anterior descending coronary artery occlusion. Total arterial occlusion was achieved by the percutaneous, transcatheter placement of a 1 mm Teflon plug int...

journal_title：Cardiovascular research

authors： Lancaster LD,Kern KB,Morrison DA,Olajos M,Goldman S

更新日期：1989-01-01 00:00:00