Abstract:
OBJECTIVES:Epidemiological evidence in humans suggests that intrauterine growth retardation is associated with an increased risk of hypertension and coronary heart disease in later life. To begin to understand the mechanisms involved, we developed and exploited a rat model of intrauterine growth retardation to assess predisposition to arrhythmias and resting blood pressure levels at defined ages from 4 to 18 months. METHODS:Isolated working heart experiments were carried out on rats that had been subjected to intrauterine growth retardation by prenatal protein deprivation and age-matched male Wistar controls to measure susceptibility to wall stress-induced arrhythmias. In addition, resting systolic and diastolic blood pressures were measured in conscious rats via an indwelling arterial catheter. RESULTS:Hearts from intrauterine growth retarded animals showed significantly more ventricular premature beats and more episodes of ventricular tachycardia at all ages examined (4, 9 and 18 months), and at 4 and 18 months, a reduction in coronary blood flow. Diastolic pressure was significantly raised by intrauterine growth retardation in both groups examined (4 and 9 months). CONCLUSIONS:Protein malnutrition during the intrauterine period results in profound intrauterine growth retardation that is associated with a raised diastolic blood pressure and an increased predisposition to cardiac arrhythmias in later life. These results are consistent with epidemiological observations made in human populations, and as similar pathophysiological changes may operate in both situations, intrauterine protein deprivation may be a useful model to help define some of the mechanisms involved.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Hu XW,Levy A,Hart EJ,Nolan LA,Dalton GR,Levi AJdoi
10.1016/s0008-6363(00)00167-xsubject
Has Abstractpub_date
2000-11-01 00:00:00pages
233-43issue
2eissn
0008-6363issn
1755-3245pii
S0008-6363(00)00167-Xjournal_volume
48pub_type
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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journal_title:Cardiovascular research
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doi:10.1093/cvr/23.11.913
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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doi:10.1016/s0008-6363(97)00189-2
更新日期:1997-11-01 00:00:00
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更新日期:1989-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvp381
更新日期:2010-04-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:1986-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/17.12.767
更新日期:1983-12-01 00:00:00
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doi:10.1016/s0008-6363(02)00601-6
更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.cardiores.2007.06.032
更新日期:2007-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvy173
更新日期:2019-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2020-10-29 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/22.1.37
更新日期:1988-01-01 00:00:00
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更新日期:2011-07-15 00:00:00
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更新日期:2014-04-01 00:00:00
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更新日期:1991-08-01 00:00:00
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更新日期:2003-07-01 00:00:00
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doi:10.1093/cvr/24.12.1013
更新日期:1990-12-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1016/s0008-6363(00)00025-0
更新日期:2000-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00455-8
更新日期:2002-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-10 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2007.03.027
更新日期:2007-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvn308
更新日期:2009-02-01 00:00:00