Protective ischaemia in patients: preconditioning and postconditioning.

abstract：AIMS:Human C-peptide has a beneficial effect on the prevention of diabetic neuropathy, nephropathy, and vascular complications; however, its role in protection against increased vascular permeability in diabetes remains unclear. Our purpose was to explore the potential protective role of C-peptide against microvascular...

journal_title：Cardiovascular research

authors： Lim YC,Bhatt MP,Kwon MH,Park D,Lee S,Choe J,Hwang J,Kim YM,Ha KS

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Growth hormone (GH) is known to induce growth of the normal rat heart. Whether this growth is due solely to hypertrophy of the cardiac myocytes or whether a concomitant hyperplasia of the cardiac myocytes also takes place is currently not known. Therefore, the aim of the present study was to investigate wheth...

journal_title：Cardiovascular research

authors： Brüel A,Christoffersen TE,Nyengaard JR

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Gap junction channels provide for direct electrical coupling between cells, and play an important role in homeostasis and electrical coupling. One of the proteins that form gap junctions, Connexin40 (Cx40), shows restricted expression in the body, and is found in blood vessels and in the atrium and conduction...

journal_title：Cardiovascular research

authors： van Rijen HV,van Veen TA,Hermans MM,Jongsma HJ

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：AIMS:The discovery of a specific prorenin receptor (PRR) suggests a biological function of prorenin that is independent of angiotensin I production. In the present study, we investigated the role of PRR on smooth muscle cell (SMC) migration. METHODS AND RESULTS:PRR was expressed in human mammary arteries and in cultur...

journal_title：Cardiovascular research

authors： Greco CM,Camera M,Facchinetti L,Brambilla M,Pellegrino S,Gelmi ML,Tremoli E,Corsini A,Ferri N

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Temporal effects of prolonged hypoxaemia and reoxygenation, on the systemic pulmonary and mesenteric circulations in newborn piglets, were investigated. METHODS:Two groups [control (n = 5), hypoxaemic (n = 7)] of 1-3 day old anaesthetised piglets were instrumented with ultrasound flow probes placed to measur...

journal_title：Cardiovascular research

authors： Cheung PY,Barrington KJ,Bigam DL

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：:Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is an...

journal_title：Cardiovascular research

authors： Cao Y,Hong A,Schulten H,Post MJ

更新日期：2005-02-15 00:00:00

abstract：AIMS:Levels of circulating CD14(high)CD16(+) monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16(+) phenotype by classical CD14(high)CD16(-) cells. We tested the hypothesis that a...

journal_title：Cardiovascular research

authors： Layne K,Di Giosia P,Ferro A,Passacquale G

更新日期：2016-07-01 00:00:00

abstract：AIMS:Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable fo...

journal_title：Cardiovascular research

authors： Bucci M,Vellecco V,Cantalupo A,Brancaleone V,Zhou Z,Evangelista S,Calderone V,Papapetropoulos A,Cirino G

更新日期：2014-04-01 00:00:00

abstract：AIMS:Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB)...

journal_title：Cardiovascular research

authors： Saito T,Hasegawa Y,Ishigaki Y,Yamada T,Gao J,Imai J,Uno K,Kaneko K,Ogihara T,Shimosawa T,Asano T,Fujita T,Oka Y,Katagiri H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that overproduction of endogenous nitric oxide (NO) during endotoxemia may modulate coronary autoregulation and myocardial reactive hyperemia. METHODS:Hearts of endotoxin-pretreated rats and controls were isolated and arranged for perfusion in a Langendorff preparation. Autor...

journal_title：Cardiovascular research

authors： Avontuur JA,Bruining HA,Ince C

更新日期：1997-08-01 00:00:00

abstract：:Little information exists regarding the effects of coronary artery occlusion on the distribution and actions of antiarrhythmic agents. We administered aprindine to dogs before, 5 min after, and 24 h after one-stage left anterior descending coronary artery (LAD) occlusion. Coronary artery occlusion performed after apri...

journal_title：Cardiovascular research

authors： Nattel S,Pedersen DH,Zipes DP

更新日期：1981-02-01 00:00:00

abstract：AIMS:G-protein-coupled receptors (GPCRs) modulate vascular tone, at least in part, via matrix metalloproteinase (MMP) transactivation of the epidermal growth factor receptor (EGFR). We previously have identified novel signalling pathways downstream of the EGFR suggestive of mitogen-activated protein kinase and mitochon...

journal_title：Cardiovascular research

authors： Nagareddy PR,Chow FL,Hao L,Wang X,Nishimura T,MacLeod KM,McNeill JH,Fernandez-Patron C

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...

journal_title：Cardiovascular research

authors： Dai-Do D,Espinosa E,Liu G,Rabelink TJ,Julmy F,Yang Z,Mahler F,Lüscher TF

更新日期：1996-11-01 00:00:00

abstract：AIMS:A cytosolic calcium (Ca(2+)(i)) increase is an important activation signal for the endothelium. We investigated whether interendothelial spreading of the Ca(2+) signal via gap junctions (GJs) plays a role for the overall Ca(2+)(i) increase in response to vasoactive agonists. METHODS AND RESULTS:In human umbilical...

journal_title：Cardiovascular research

authors： Kameritsch P,Pogoda K,Ritter A,Münzing S,Pohl U

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:The function of angiotensin converting enzyme (ACE) at cell sites of high collagen turnover, such as heart valves, is uncertain. The aim of this study was to assess ACE and kininase-II-like activities and collagen turnover in cultured valvular interstitial cells of the adult rat heart. METHODS:The valvular i...

journal_title：Cardiovascular research

authors： Katwa LC,Ratajska A,Cleutjens JP,Sun Y,Zhou G,Lee SJ,Weber KT

更新日期：1995-01-01 00:00:00

abstract：:CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflamm...

journal_title：Cardiovascular research

authors： Mesubi OO,Anderson ME

更新日期：2016-04-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a major risk factor for cardio-embolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern. This study sought to identify new targets to develop safer antithrombotic therapie...

journal_title：Cardiovascular research

authors： Allende M,Molina E,Guruceaga E,Tamayo I,González-Porras JR,Gonzalez-López TJ,Toledo E,Rabal O,Ugarte A,Roldán V,Rivera J,Oyarzabal J,Montes R,Hermida J

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes. We aimed to investigate the mechanisms underlying the anoxia-induced activation of K+(ATP) channels. METHODS:Guinea pig ventricular myocytes were isolated using collagenase digestion....

journal_title：Cardiovascular research

authors： Shigematsu S,Arita M

更新日期：1997-08-01 00:00:00

abstract：:Mouse models have been frequently used in the study of Chlamydia pneumoniae (also known as Chlamydophila pneumoniae) infections. This gram-negative obligate intracellular bacterium causes respiratory infections, followed by dissemination of the bacterium to various organs throughout the body, including cardiovascular ...

journal_title：Cardiovascular research

authors： de Kruif MD,van Gorp EC,Keller TT,Ossewaarde JM,ten Cate H

更新日期：2005-02-01 00:00:00

abstract：AIMS:Bone marrow (BM) progenitor cells may contribute to vascular remodelling. The present study aimed to investigate the contribution of BM-derived CXCR4(+) (a CXC chemokine receptor) and PDGFRbeta(+) (platelet-derived growth factor receptor beta) progenitor cells in hypoxia-induced muscularization of alveolar arterio...

journal_title：Cardiovascular research

authors： Jie W,Wang X,Huang L,Guo J,Kuang D,Zhu P,Li M,Zhao X,Duan Y,Wang G,Ao Q

更新日期：2010-09-01 00:00:00

abstract：:To examine how end systole differs from end ejection and also whether the slope of the end systolic pressure-volume relation can be approximated to that of the end ejection pressure-volume relation, nine isolated, perfused, paced canine hearts ejecting into a hydraulic loading system that simulated the aortic input im...

journal_title：Cardiovascular research

authors： Nishioka O,Maruyama Y,Ashikawa K,Isoyama S,Satoh S,Suzuki H,Watanabe J,Watanabe H,Shimizu Y,Ino-Oka E

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS:Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an ...

journal_title：Cardiovascular research

authors： Sipkema P,Takkenberg JJ,Zeeuwe PE,Westerhof N

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Stretch-activated cation channels (SAC) have been suggested to act as endothelial mechanosensors for hemodynamic forces. Ca(2+) influx through SAC could induce an intracellular Ca(2+) signal stimulating Ca(2+)-dependent synthesis of vasodilators like NO, prostacyclin, or EDHF. In the present study we tested w...

journal_title：Cardiovascular research

authors： Brakemeier S,Eichler I,Hopp H,Köhler R,Hoyer J

更新日期：2002-01-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is associated with both acute and late onset cardiotoxicity, limiting its overall efficacy. Here, the impact of cardiomyocyte cell cycle activation was examined in a juvenile model featuring aspects of acute and late onset DOX ...

journal_title：Cardiovascular research

authors： Zhu W,Reuter S,Field LJ

更新日期：2019-04-15 00:00:00

abstract：STUDY OBJECTIVE:The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate. DESIGN:Diastolic left atrial and left ventricular pressures were recorded at high sensitivity (40 mm Hg = 10 mm recorded deflection) ...

journal_title：Cardiovascular research

authors： Carmeliet P,Aubert A,Van de Werf F,De Geest H

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：:Elevated sympathetic activity changes renal function and accelerates the development of hypertension. Principles of sympatho-renal interactions in chronic hypertension are reviewed. Alterations in the ontogeny of the sympathetic nervous system and the kidney, inherited abnormalities in sensory receptor function and ex...

journal_title：Cardiovascular research

authors： Grisk O,Rettig R

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Ischaemia followed by reperfusion brings about a reduction in cardiac capillary cross-sectional dimensions which is consistent with constriction. The aim of this study was to test the hypothesis that the reduction in cardiac capillary dimensions that occurs in ischaemia and reperfusion is caused by endothelia...

journal_title：Cardiovascular research

authors： Glyn MC,Ward BJ

更新日期：2000-11-01 00:00:00