Abstract：
STUDY OBJECTIVE:The aim was to investigate whether basal coronary vascular tone and myocardial perfusion depend upon endothelial nitric oxide (NO) synthesis. DESIGN:Myocardial blood flow and vascular resistance of the left and right ventricles were studied before and after intravenous infusions of either NG-nitro-L-arginine (L-NA), a specific inhibitor of NO synthase, or L-arginine, the precursor of NO synthesis. Radiolabelled microspheres were used to study myocardial blood flow in small tissue sections. EXPERIMENTAL MATERIAL:14 anaesthetised male cats, weight 2.1-3.5 kg, were used. MEASUREMENTS AND MAIN RESULTS:Measurements were made before and 15 and 40 min after L-NA treatment (30 mg.kg-1 bolus followed by 1 mg.kg-1.min-1 infusion; n = 8), and before and 15 min after L-arginine treatment (30 mg.kg-1 bolus followed by 10 mg.kg-1.min-1 infusion; n = 6). L-NA significantly reduced coronary blood flow to the left and right ventricle, by 30(SEM 9) and 48(6)% respectively, after 15 min, but only to the right ventricle, by 45(8)%, after 40 min. Mean arterial pressure and myocardial vascular resistance were raised during the L-NA infusion. In contrast, L-arginine did not elicit any change in the variables studied. CONCLUSIONS:The conductance of the coronary vascular bed and the resting myocardial blood flow is regulated by L-arginine derived nitric oxide, and exogenous L-arginine availability is not a limiting factor in this NO generation.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Benyó Z,Kiss G,Szabó C,Csáki C,Kovách AGdoi
10.1093/cvr/25.8.700subject
Has Abstractpub_date
1991-08-01 00:00:00pages
700-3issue
8eissn
0008-6363issn
1755-3245journal_volume
25pub_type
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journal_title：Cardiovascular research
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journal_title：Cardiovascular research
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doi：10.1016/s0008-6363(98)00191-6
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journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.9.690
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doi：10.1016/0008-6363(96)00052-1
更新日期：1996-08-01 00:00:00
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更新日期：2005-06-01 00:00:00
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journal_title：Cardiovascular research
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doi：10.1093/cvr/27.6.990
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journal_title：Cardiovascular research
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更新日期：2008-05-01 00:00:00
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doi：10.1093/cvr/27.8.1542
更新日期：1993-08-01 00:00:00
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journal_title：Cardiovascular research
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更新日期：2011-07-15 00:00:00
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journal_title：Cardiovascular research
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doi：10.1093/cvr/9.4.515
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更新日期：1999-12-01 00:00:00
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更新日期：1999-10-01 00:00:00
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journal_title：Cardiovascular research
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doi：10.1093/cvr/24.1.19
更新日期：1990-01-01 00:00:00
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更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/cvr/15.12.711
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更新日期：2016-04-01 00:00:00
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journal_title：Cardiovascular research
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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