Abstract：
OBJECTIVE:The aim was to validate echocardiographic assessment of acute changes of left ventricular stroke volume in normal rats. METHODS:By transthoracic use of a 7.5 MHz ultrasonic transducer, the left ventricular dimensions were determined before and during rapid atrial pacing and saline infusion in seven Wistar rats weighing 310-470 g. Left ventricular volume was calculated from short axis dimensions according to a cube function formula. Echo stroke volume (SVE) was then compared with that obtained simultaneously using a pulsed Doppler flow meter placed around the ascending aorta (SVF). RESULTS:The SVE (ml) was decreased from 0.30(SD 0.12) to 0.13(0.06) by rapid pacing and increased from 0.27(0.12) to 0.63(0.16) by volume loading. Regression analysis showed high correlations between SVE and SVF during both pacing (r = 0.84) and infusion (r = 0.91) studies. Furthermore, correlations between SVE and SVF in individual animals were very close (r = 0.87-0.99 in the pacing study and 0.92-0.99 in the volume study). Interobserver and intraobserver variances were small, with close correlations (r = 0.96-0.99) and modest standard errors of the estimate (0.02-0.04 ml) between the two measurements. CONCLUSIONS:Echocardiography allows reliable in vivo measurement of cavity dimensions and assessment of acute alterations in stroke volume in normal rats.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Nakamura T,Matsumuro A,Kuribayashi T,Matsubara K,Shima M,Shimoo K,Katsume H,Nakagawa Mdoi
10.1093/cvr/26.8.765subject
Has Abstractpub_date
1992-08-01 00:00:00pages
765-9issue
8eissn
0008-6363issn
1755-3245journal_volume
26pub_type
杂志文章abstract：:The purpose of this review is to give an integrative view of the effect of stretch on the myocardium from ventricular function changes to cellular and molecular mechanisms. The general approach will be to discuss the cellular and molecular events which can explain the findings obtained in the whole ventricle. Followin...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：:Studies were carried out in four different canine preparations to determine the effect of collateral flow on early changes induced by acute segmental ischaemia. The results of these experiments indicated that collateral flow provided a limited and variable amount of protection. When collateral flow was eliminated, myo...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/12.5.309
更新日期：1978-05-01 00:00:00
abstract：OBJECTIVE:Cytokine induction of intercellular adhesion molecule-1 (ICAM-1) on cardiac myocytes may be a critical step in cardiac inflammation associated with acute myocardial infarction and myocarditis. The aim of this study was to investigate the involvement of monocyte chemoattractant protein-1 (MCP-1), a homologue o...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/28.8.1258
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(97)00063-1
更新日期：1997-06-01 00:00:00
abstract：:Atherosclerosis is characterized by a persistent, low-grade inflammation of the arterial wall. Monocytes and monocyte-derived macrophages play a pivotal role in the various stages of atherosclerosis. In the past few years, metabolic reprogramming has been identified as an important controller of myeloid cell activatio...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvz107
更新日期：2019-07-01 00:00:00
abstract：:To improve assessment of ventricular function during cardiac catheterisation there should be available a continuous registration of stroke volume and cardiac output in addition to ventricular pressure. To obtain the desired volumetric quantities a catheter has been developed which measures changes in intraventricular ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/15.6.328
更新日期：1981-06-01 00:00:00
abstract：OBJECTIVE:Previous studies have shown that cardiac protection by ischaemic preconditioning wanes before contractile function recovers; thus stunning is insufficient to cause preconditioning. To test whether reduced contractile effort is necessary for preconditioning induced protection, the effect on myocardial infarct ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.4.585
更新日期：1993-04-01 00:00:00
abstract：AIMS:The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and concentric hypertrop...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvs164
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal art...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/15.7.373
更新日期：1981-07-01 00:00:00
abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvz331
更新日期：2021-01-01 00:00:00
abstract：AIMS:Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable fo...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu026
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS:Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(98)00119-9
更新日期：1998-10-01 00:00:00
abstract：:If the posterior hypothalamus contributes to elevate blood pressure in hypertension by increasing sympathetic vasomotor activity, then lesions of the posterior hypothalamus should lower blood pressure more in hypertensive than in normotensive rats. To test this hypothesis without complications caused by anaesthesia, a...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/10.6.663
更新日期：1976-11-01 00:00:00
abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/21.11.804
更新日期：1987-11-01 00:00:00
abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvt080
更新日期：2013-07-01 00:00:00
abstract：AIMS:Adrenomedullin (AM) is a multifunctional peptide hormone that plays a significant role in vasodilation and angiogenesis. Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedem...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvn228
更新日期：2008-12-01 00:00:00
abstract：:The voltage- and rate-dependence of the depression of the maximum rate of depolarisation (Vmax) by therapeutic concentrations of flecainide and lorcainide were studied in guinea-pig ventricle by standard microelectrode techniques. At normal resting potentials the drugs produced only minor depression of Vmax in the abs...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/17.5.251
更新日期：1983-05-01 00:00:00
abstract：:The renin-angiotensin-aldosterone (RAA) system and the endothelin (ET) system entail the most potent vasopressor mechanisms identified to date. Although they were studied in depth in relation to arterial hypertension and cardiovascular diseases, limited information on their interrelationships in causing hypertension a...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(99)00110-8
更新日期：1999-08-01 00:00:00
abstract：AIMS:Hypercholesterolaemia and myeloperoxidase (MPO) overexpression are two well-recognized risk factors for ischaemic heart disease. Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists have recently been shown to reduce ischaemic heart injury in hypercholesterolaemic animals. However, whether PPARgam...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvn308
更新日期：2009-02-01 00:00:00
abstract：AIMS:Fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD) are related, non-atherosclerotic arterial diseases mainly affecting middle-aged women. Little is known about their physiopathological mechanisms. We aimed to identify rare genetic causes to elucidate molecular mechanisms implicated in ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvaa161
更新日期：2020-06-12 00:00:00
abstract：:Since increases in blood pressure may be effectively controlled by hydraulic feedback by reducing the venous return through the inferior vena cava in proportion to the blood pressure this principle was applied using a totally implantable extravascular system consisting of a periaortic blood pressure sensor and a peric...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/21.5.337
更新日期：1987-05-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to investigate the relationship between acute decreases in right ventricular volume during Valsalva strain (with resultant changes in autonomic neural tone) and measures of local endocardial repolarization time independent of heart rate and autonomic neural tone. METHODS:Patie...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(99)00261-8
更新日期：2000-01-14 00:00:00
abstract：:The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding o...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvr078
更新日期：2011-07-15 00:00:00
abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2007.06.032
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:Transiently altering the atrial activation sequence induces atrial memory, manifested as an altered atrial gradient as measured in electrocardiographic XYZ leads. We hypothesized that protracted periods of left atrial impulse initiation alter the atrial gradient in a manner predictive of arrhythmias. METHODS...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(03)00536-4
更新日期：2003-11-01 00:00:00
abstract：:An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the inti...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/15.8.456
更新日期：1981-08-01 00:00:00
abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/9.5.621
更新日期：1975-09-01 00:00:00
abstract：:The velocity of contraction has been reported to be more rapid in left atrium (LA) than left ventricle (LV), but the mechanics of contraction in these two chambers have not been compared under physiological conditions. Accordingly, sonomicrometer crystals and solid state pressure transducers were used to measure LV an...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/18.10.604
更新日期：1984-10-01 00:00:00
abstract：AIMS:Placental growth factor (PlGF), a homologue of vascular endothelial growth factor, is a pleiotropic cytokine with a pro-inflammatory activity. Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an ant...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvp380
更新日期：2010-04-01 00:00:00
