Apparent pulse wave velocity in the canine superior vena cava.

abstract：BACKGROUND:Clinical trials suggest that sotalol and dofetilide are much more effective in preventing atrial fibrillation (AF) than in terminating it. This study evaluated potential mechanisms of discordant sotalol and dofetilide effects on AF termination vs. prevention. METHODS:We applied 240-electrode epicardial mapp...

journal_title：Cardiovascular research

authors： Derakhchan K,Villemaire C,Talajic M,Nattel S

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Insulin seems to have vasodilator properties, but it is unclear if insulin in postprandial concentrations is a specific vasodilator of skeletal muscle resistance arterioles only or that various types of vessels are affected. The aim of the present study was to determine the direct effects and the time course ...

journal_title：Cardiovascular research

authors： de Haan CH,van Dielen FM,Houben AJ,de Leeuw PW,Huvers FC,De Mey JG,Wolffenbuttel BH,Schaper NC

更新日期：1997-04-01 00:00:00

abstract：:The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a pro-angiogenic cytokine for the treatment of ischaemic heart disease. While VEGF binds to two receptor protein tyrosine kinases, VEGFR1...

journal_title：Cardiovascular research

authors： Zachary I,Gliki G

更新日期：2001-02-16 00:00:00

abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...

journal_title：Cardiovascular research

authors： Teng B,Smith JD,Rosenfeld ME,Robinet P,Davis ME,Morrison RR,Mustafa SJ

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Neointimal hyperplasia is a central feature in the pathogenesis of a variety of vascular pathologies. Mitogen-activated protein kinases (MAPK) are involved in the downstream transduction of signals from receptors for many of the molecules known to be instrumental in this process and thus represent a potential...

journal_title：Cardiovascular research

authors： Liu B,Fisher M,Groves P

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:In the myocardium, myocyte cell division is irreversibly blocked shortly after birth. The signal that initiates cell cycle withdrawal is unknown. The purpose of this study was to relate changes in expression of beta1 integrin and its associated alpha subunits to cardiomyocyte cell cycle progression during th...

journal_title：Cardiovascular research

authors： Maitra N,Flink IL,Bahl JJ,Morkin E

更新日期：2000-09-01 00:00:00

abstract：:Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent...

journal_title：Cardiovascular research

authors： Spadaccio C,Antoniades C,Nenna A,Chung C,Will R,Chello M,Gaudino MFL

更新日期：2020-03-01 00:00:00

abstract：:The velocity of contraction has been reported to be more rapid in left atrium (LA) than left ventricle (LV), but the mechanics of contraction in these two chambers have not been compared under physiological conditions. Accordingly, sonomicrometer crystals and solid state pressure transducers were used to measure LV an...

journal_title：Cardiovascular research

authors： Goldman S,Olajos M,Morkin E

更新日期：1984-10-01 00:00:00

abstract：AIMS:The discovery of a specific prorenin receptor (PRR) suggests a biological function of prorenin that is independent of angiotensin I production. In the present study, we investigated the role of PRR on smooth muscle cell (SMC) migration. METHODS AND RESULTS:PRR was expressed in human mammary arteries and in cultur...

journal_title：Cardiovascular research

authors： Greco CM,Camera M,Facchinetti L,Brambilla M,Pellegrino S,Gelmi ML,Tremoli E,Corsini A,Ferri N

更新日期：2012-08-01 00:00:00

abstract：AIM:To assess whether endothelin-1 (ET-1) induces the in vivo expression of inflammatory-related proteins, namely cyclooxygenase-2 (COX-2) and tissue factor, in the myocardium and circulating leukocytes of guinea-pigs. The involvement of platelets was also analyzed. METHODS:ET-1 (0.013 microg/min) was infused to male ...

journal_title：Cardiovascular research

authors： Molero L,Farré J,García-Mendez A,Jiménez Mateos-Caceres P,Carrasco Martín C,Millás I,Navarro F,Córdoba M,Casado S,López-Farré A

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:This study investigated whether endothelial dysfunction occurs in mesenteric arteries of apoE-deficient mice and determined the role of endothelin (ET)-1, which is increased in human atherosclerosis, using an orally active endothelin ET(A) receptor antagonist. METHODS:ApoE-deficient and C57BL/6J control mice...

journal_title：Cardiovascular research

authors： d'Uscio LV,Barton M,Shaw S,Lüscher TF

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:Recombinant retroviral vectors have been shown to be useful tools for marking cells so as to follow their fates during development. The aim of this study was to determine the utility and advantages of an adenoviral vector as a tool to study the heart as it develops from a simple tube into a complex four-cham...

journal_title：Cardiovascular research

authors： Fisher SA,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death in heart failure but it must be demonstrated by multiple criteria and not just TUNEL staining alone. Previously, we and others have demonstrated that be...

journal_title：Cardiovascular research

authors： Knaapen MW,Davies MJ,De Bie M,Haven AJ,Martinet W,Kockx MM

更新日期：2001-08-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：:Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue devi...

journal_title：Cardiovascular research

authors： Lab MJ,Gartside I,Wassermann S

更新日期：1983-12-01 00:00:00

abstract：AIMS:A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel an...

journal_title：Cardiovascular research

authors： Bevan L,Lim ZW,Venkatesh B,Riley PR,Martin P,Richardson RJ

更新日期：2020-06-01 00:00:00

abstract：:Congestive heart failure may be deemed the epidemic of cardiology in the 21st century in the industrialized part of the world. Although new therapies improving morbidity and mortality from chronic heart failure have emerged it is likely that there is a growing role for digoxin. Thus, digoxin treatment is known to cont...

journal_title：Cardiovascular research

authors： Kjeldsen K,Nørgaard A,Gheorghiade M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the role of nitric oxide (NO) in the myocardial microcirculation. METHODS:Open chest anaesthetised dogs received intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA; 0.5 mg.kg-1 over 30 min). Myocardial microvascular extraction fraction of a small hydrophilic solute (technetium ...

journal_title：Cardiovascular research

authors： Hansen PR,Haunsø S

更新日期：1995-06-01 00:00:00

abstract：:The effect of chronic propranolol administration (2 mg.kg-1.d-1 for 14d) and withdrawal on microvascular perfusion was studied in rabbit myocardium. Fluorescein isothiocyanate-dextran was injected into four groups of anaesthetised open chest rabbits. Fluorescent microscopy was used to identify the perfused vessels and...

journal_title：Cardiovascular research

authors： Acad BA,Shenko JM,Eliades D,Weiss HR

更新日期：1988-11-01 00:00:00

abstract：:Since increases in blood pressure may be effectively controlled by hydraulic feedback by reducing the venous return through the inferior vena cava in proportion to the blood pressure this principle was applied using a totally implantable extravascular system consisting of a periaortic blood pressure sensor and a peric...

journal_title：Cardiovascular research

authors： Sideris DA,Vardas PE,Chrysos DN,Toumanidis ST,Michalis L,Moulopoulos SD

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes. We aimed to investigate the mechanisms underlying the anoxia-induced activation of K+(ATP) channels. METHODS:Guinea pig ventricular myocytes were isolated using collagenase digestion....

journal_title：Cardiovascular research

authors： Shigematsu S,Arita M

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin in myocardium increased cardiac relaxation in vitro as well as in vivo. Therefore, the objective of this study is to test...

journal_title：Cardiovascular research

authors： Schmidt U,Zhu X,Lebeche D,Huq F,Guerrero JL,Hajjar RJ

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive he...

journal_title：Cardiovascular research

authors： Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JM

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

journal_title：Cardiovascular research

authors： Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVES:Myostatin, a member of the transforming growth factor-beta (TGF-beta) family, plays a key role in skeletal muscle myogenesis by limiting hyperplastic and hypertrophic muscle growth. In cardiac muscle, myostatin has been shown to limit agonist-induced cardiac hypertrophic growth. However, its role in cardiac ...

journal_title：Cardiovascular research

authors： McKoy G,Bicknell KA,Patel K,Brooks G

更新日期：2007-05-01 00:00:00

abstract：AIMS:Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) currents have never been studied in these two vessels. Our study was init...

journal_title：Cardiovascular research

authors： Smirnov SV,Loutzenhiser K,Loutzenhiser R

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Catechol O-methyltransferase (COMT) is believed to exert degradative action at high norepinephrine (NE) levels. Although COMT exists in cardiac tissues, the contribution of cardiac COMT activity to regional NE kinetics, particularly in ischemia-induced NE accumulation, remains unclear. We investigated the rol...

journal_title：Cardiovascular research

authors： Fujii T,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:To assess the functional effects of multipotent adult progenitor cells (MAPCs) transplanted in a rat model of chronic myocardial infarction. METHODS:Forty-four rats underwent coronary ligation and, 14 days later, were randomly allocated to receive in-scar injections (5 x 10(6) cells/150 microL) of green flu...

journal_title：Cardiovascular research

authors： Agbulut O,Mazo M,Bressolle C,Gutierrez M,Azarnoush K,Sabbah L,Niederlander N,Abizanda G,Andreu EJ,Pelacho B,Gavira JJ,Perez-Ilzarbe M,Peyrard S,Bruneval P,Samuel JL,Soriano-Navarro M,García-Verdugo JM,Hagège AA,Próspe

更新日期：2006-10-01 00:00:00

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00