Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice.

abstract：OBJECTIVE:Atrial remodeling contributes to the maintenance of atrial fibrillation (AF) in several cardiac disorders. There is evidence that angiotensin-converting enzyme (ACE) inhibitors reduce the prevalence of AF in patients with congestive heart failure (CHF). There have been no studies performed to assess the effec...

journal_title：Cardiovascular research

authors： Shi Y,Li D,Tardif JC,Nattel S

更新日期：2002-05-01 00:00:00

abstract：UNLABELLED:Recent investigations have established the feasibility of using exogenously delivered angiogenic growth factors to increase collateral artery development in animal models of myocardial and hindlimb ischemia. OBJECTIVE:Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth facto...

journal_title：Cardiovascular research

authors： Hershey JC,Corcoran HA,Baskin EP,Gilberto DB,Mao X,Thomas KA,Cook JJ

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The aim was to study L type calcium current alterations in relation to the action potential lengthening induced by hypertrophy in isolated cardiomyocytes from the right ventricle of ferret. METHODS:Chronic pulmonary artery constriction was established in adult male ferrets under anaesthesia. Sham operated an...

journal_title：Cardiovascular research

authors： Bouron A,Potreau D,Raymond G

更新日期：1992-07-01 00:00:00

abstract：AIMS:Hypertension is a risk factor for atherothrombotic vascular events. Angiotensin II (Ang II), one of the main vasoactive hormones of the renin-angiotensin system, has been associated with the development and progression of atherosclerosis. However, it is not fully known how Ang II contributes to lipid-enriched athe...

journal_title：Cardiovascular research

authors： Sendra J,Llorente-Cortés V,Costales P,Huesca-Gómez C,Badimon L

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

journal_title：Cardiovascular research

authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Thrombin induces endothelial barrier failure by activating the contractile machinery of endothelial cells. Contractile activation is due to an increase in myosin light chain (MLC) phosphorylation. Here, it was investigated whether stimulation of endothelial cells with ATP can interrupt this thrombin-induced ...

journal_title：Cardiovascular research

authors： Gündüz D,Hirche F,Härtel FV,Rodewald CW,Schäfer M,Pfitzer G,Piper HM,Noll T

更新日期：2003-08-01 00:00:00

abstract：AIMS:Human C-peptide has a beneficial effect on the prevention of diabetic neuropathy, nephropathy, and vascular complications; however, its role in protection against increased vascular permeability in diabetes remains unclear. Our purpose was to explore the potential protective role of C-peptide against microvascular...

journal_title：Cardiovascular research

authors： Lim YC,Bhatt MP,Kwon MH,Park D,Lee S,Choe J,Hwang J,Kim YM,Ha KS

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the impact of cilazaprilat on PMN dependent reperfusion injury in isolated g...

journal_title：Cardiovascular research

authors： Kupatt C,Habazettl H,Zahler S,Weber C,Becker BF,Messmer K,Gerlach E

更新日期：1997-12-01 00:00:00

abstract：:The effect of adding fibrinolytic to penicillin therapy in experimentally induced streptococcal bacterial endocarditis has been studied in the rabbit. In 9 day old infected lesions, the vegetations could be substantially reduced in size after a 3 day course of intravenous streptokinase. Quantitative microbiological te...

journal_title：Cardiovascular research

authors： Johnson CE,Dewar HA,Aherne WA

更新日期：1980-08-01 00:00:00

abstract：ABSTRACT:Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an overwhelming host response to infection resulting in organ failure. The endothelium is an active contributor to sepsis and as such represents a major target for therapy. During sepsis, endothelial cells amplify the immune response...

journal_title：Cardiovascular research

authors： Dolmatova EV,Wang K,Mandavilli R,Griendling KK

更新日期：2021-01-01 00:00:00

abstract：AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

journal_title：Cardiovascular research

authors： Hu K,Scheer FA,Buijs RM,Shea SA

更新日期：2008-10-01 00:00:00

abstract：AIMS:Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS:Experimental myocardial infarction (MI) was created in CTSL-defi...

journal_title：Cardiovascular research

authors： Sun M,Chen M,Liu Y,Fukuoka M,Zhou K,Li G,Dawood F,Gramolini A,Liu PP

更新日期：2011-02-01 00:00:00

abstract：AIMS:Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS:Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naï...

journal_title：Cardiovascular research

authors： MacRitchie N,Grassia G,Noonan J,Cole JE,Hughes CE,Schroeder J,Benson RA,Cochain C,Zernecke A,Guzik TJ,Garside P,Monaco C,Maffia P

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Automatic analysis of the frequency content of the fibrillatory baseline on the surface ECG accurately reflects the average rate of atrial fibrillation (AF). This frequency measurement correlates with the behavior of AF and predicts the response to administration of ibutilide, a new antiarrhythmic drug. Neith...

journal_title：Cardiovascular research

authors： Bollmann A,Sonne K,Esperer HD,Toepffer I,Langberg JJ,Klein HU

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Lipoprotein lipase (LPL) mediated hydrolysis of circulating triglyceride (TG)-rich lipoproteins provides the heart with fatty acids. The present study was designed to investigate the influence of circulating TG and their lipolysis in facilitating translocation of LPL from the underlying cardiomyocyte cell sur...

journal_title：Cardiovascular research

authors： Pulinilkunnil T,Qi D,Ghosh S,Cheung C,Yip P,Varghese J,Abrahani A,Brownsey R,Rodrigues B

更新日期：2003-09-01 00:00:00

abstract：:Ultrasound has become a useful high resolution imaging modality for examining the cardiac microcirculation. With the use of microbubbles as an ultrasound contrast agent, ultrasound can be utilized to image the microcirculation and detect capillary flow abnormalities in acute ischaemia. A wide range of ultrasound frequ...

journal_title：Cardiovascular research

authors： Porter TR

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:In the myocardium, myocyte cell division is irreversibly blocked shortly after birth. The signal that initiates cell cycle withdrawal is unknown. The purpose of this study was to relate changes in expression of beta1 integrin and its associated alpha subunits to cardiomyocyte cell cycle progression during th...

journal_title：Cardiovascular research

authors： Maitra N,Flink IL,Bahl JJ,Morkin E

更新日期：2000-09-01 00:00:00

abstract：AIMS:The aim of this study was to explore meprinα-mediated transactivation of the epidermal growth factor receptor (EGFR) and reactive oxygen species (ROS) production in macrophages. METHODS AND RESULTS:Accelerated atherosclerotic lesions were established by administration of a high-fat diet in apolipoprotein E-defici...

journal_title：Cardiovascular research

authors： Gao P,Wang XM,Qian DH,Qin ZX,Jin J,Xu Q,Yuan QY,Li XJ,Si LY

更新日期：2013-03-01 00:00:00

abstract：:The effects of both gradual and abrupt coronary occlusion on regional wall function (sonomicrometry) and left ventricular relaxation were studied in the intact dog heart. The ischaemic dysfunction observed in the two interventions as assessed by pressure-length loops showed considerably different patterns. The regiona...

journal_title：Cardiovascular research

authors： Doyle RL,Foëx P,Ryder WA,Jones LA

更新日期：1987-07-01 00:00:00

abstract：:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

journal_title：Cardiovascular research

authors： Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Lower limb perfusion following arterial occlusion depends on the recruitment of collateral vessels. Blood flow through these collateral vessels may be jeopardized by hypersensitivity to vasoconstriction by serotonin (5-HT), as has been reported during hyperlipidemia and diabetes. Therefore the aim of this stu...

journal_title：Cardiovascular research

authors： Janiak P,Lainée P,Grataloup Y,Luyt CE,Bidouard JP,Michel JB,O'Connor SE,Herbert JM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...

journal_title：Cardiovascular research

authors： Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

更新日期：1996-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:To assess the functional effects of multipotent adult progenitor cells (MAPCs) transplanted in a rat model of chronic myocardial infarction. METHODS:Forty-four rats underwent coronary ligation and, 14 days later, were randomly allocated to receive in-scar injections (5 x 10(6) cells/150 microL) of green flu...

journal_title：Cardiovascular research

authors： Agbulut O,Mazo M,Bressolle C,Gutierrez M,Azarnoush K,Sabbah L,Niederlander N,Abizanda G,Andreu EJ,Pelacho B,Gavira JJ,Perez-Ilzarbe M,Peyrard S,Bruneval P,Samuel JL,Soriano-Navarro M,García-Verdugo JM,Hagège AA,Próspe

更新日期：2006-10-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：:Zero drift may be a cause of imprecision when micromanometer tipped catheters are used for intravascular pressure measurement over long periods of time. Drift of only a few mm Hg may represent a significant error when accurate recording of low vascular pressures is required. To overcome this problem a micromanometer t...

journal_title：Cardiovascular research

authors： Gibbs JS,Cunningham D,Sparrow J,Poole-Wilson PA,Fox KM

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:The presence is well established in unstable angina of intracoronary thrombosis in a stenosed epicardial coronary artery. The effects of the thrombus formation on the distal microcirculation are however still unclear. METHODS:We adapted the Folts canine model of left circumflex coronary arterial stenosis and...

journal_title：Cardiovascular research

authors： Mansaray M,Belcher PR,Vergroesen I,Wright ZM,Hynd JW,Drake-Holland AJ,Noble MI

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Nitric oxide (NO) has been shown to induce apoptosis in cardiomyocytes under normoxic conditions. The ability of NO to induce apoptosis after ischemia-reperfusion, a situation of increased NO release in vivo, has not been investigated. The present study was undertaken to characterize the pathway of induction ...

journal_title：Cardiovascular research

authors： Taimor G,Hofstaetter B,Piper HM

更新日期：2000-02-01 00:00:00