Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension.

abstract：:This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14...

journal_title：Cardiovascular research

authors： Sen S,Tarazi RC,Bumpus FM

更新日期：1976-03-01 00:00:00

abstract：STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

journal_title：Cardiovascular research

authors： Wright G

更新日期：1991-11-01 00:00:00

abstract：UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performa...

journal_title：Cardiovascular research

authors： Tyni-Lenné R,Jansson E,Sylvén C

更新日期：1999-04-01 00:00:00

abstract：:The effect on the microcirculation of long term administration of the alpha 1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg.litre-1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity ...

journal_title：Cardiovascular research

authors： Dawson JM,Hudlická O

更新日期：1989-11-01 00:00:00

abstract：:To evaluate the effect of beta blockade on energy metabolism in ischaemic myocardium metoprolol tartrate in doses of 0.2 or 0.5 mg.kg-1 or saline was injected into 24 anaesthetised dogs 20 min after coronary ligation. Regional myocardial blood flow was measured by the hydrogen gas clearance method, and the heart rate ...

journal_title：Cardiovascular research

authors： Nanki M,Itoh K,Matsubara T,Nishimura K,Kambe T,Sugiyama S,Ozawa T,Sakamoto N

更新日期：1987-09-01 00:00:00

abstract：:Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool, an abundance of inflammatory cells and mediators, a reduced smooth muscle cell and collagen content and a thin overlying fibrous cap. Potential...

journal_title：Cardiovascular research

authors： Rabbani R,Topol EJ

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Increased cardiac collagen is seen in uninephrectomised rats made hypertensive by aldosterone infusion and high salt, with the possibility of a direct effect of aldosterone at the level of the cardiac fibroblast. The aim of this study was to examine the effects of aldosterone, glucocorticoids, and angiotensin...

journal_title：Cardiovascular research

authors： Fullerton MJ,Funder JW

更新日期：1994-12-01 00:00:00

abstract：AIMS:Fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD) are related, non-atherosclerotic arterial diseases mainly affecting middle-aged women. Little is known about their physiopathological mechanisms. We aimed to identify rare genetic causes to elucidate molecular mechanisms implicated in ...

journal_title：Cardiovascular research

authors： Georges A,Albuisson J,Berrandou T,Dupré D,Lorthioir A,D'Escamard V,Di Narzo AF,Kadian-Dodov D,Olin JW,Warchol-Celinska E,Prejbisz A,Januszewicz A,Bruneval P,Baranowska AA,Webb TR,Hamby SE,Samani NJ,Adlam D,Fendrikova-

更新日期：2020-06-12 00:00:00

abstract：AIMS:Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma isoforms and their downstream effector pathways in mediating endothe...

journal_title：Cardiovascular research

authors： Heller R,Chang Q,Ehrlich G,Hsieh SN,Schoenwaelder SM,Kuhlencordt PJ,Preissner KT,Hirsch E,Wetzker R

更新日期：2008-10-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

journal_title：Cardiovascular research

authors： Sawanobori T,Hirano Y,Hiraoka M

更新日期：1987-11-01 00:00:00

abstract：AIMS:Sulfur dioxide (SO₂) is an air pollutant that impedes neonatal development and induces adverse cardiorespiratory health effects, including tachycardia. Here, an animal model was developed that enabled characterization of (i) in vivo alterations in heart rate and (ii) altered activity in brainstem neurons that cont...

journal_title：Cardiovascular research

authors： Woerman AL,Mendelowitz D

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Nitric oxide (NO) has complex effects on myocardial function particularly following ischaemia-reperfusion. The goal of this study was to examine the result of repetitive myocardial stunning on myocardial NO release and expression of inducible (iNOS) and constitutive (eNOS) NO synthases. METHODS AND RESULTS:...

journal_title：Cardiovascular research

authors： Baker CS,Rimoldi O,Camici PG,Barnes E,Chacon MR,Huehns TY,Haskard DO,Polak JM,Hall RJ

更新日期：1999-08-15 00:00:00

abstract：OBJECTIVE:The aim was to examine the role of nitric oxide (NO) in the myocardial microcirculation. METHODS:Open chest anaesthetised dogs received intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA; 0.5 mg.kg-1 over 30 min). Myocardial microvascular extraction fraction of a small hydrophilic solute (technetium ...

journal_title：Cardiovascular research

authors： Hansen PR,Haunsø S

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Myogenic tone, which has a major role in the regulation of local blood flow, refers to the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure. Although Rho-kinase is involved in myogenic tone, the pathway involved remains unclear, especially concerning translocation...

journal_title：Cardiovascular research

authors： Dubroca C,Loyer X,Retailleau K,Loirand G,Pacaud P,Feron O,Balligand JL,Lévy BI,Heymes C,Henrion D

更新日期：2007-01-01 00:00:00

abstract：AIM:Diabetes is a conventional risk factor for atherosclerotic cardiovascular disease and myocardial infarction (MI) is the most common cause of death among these patients. Mesenchymal stromal cells (MSCs) in patients with type 2 diabetes (T2DM) and atherosclerosis have impaired ability to suppress activated T-cells (i...

journal_title：Cardiovascular research

authors： Mancini OK,Huynh DN,Menard L,Shum-Tim D,Ong H,Marleau S,Colmegna I,Servant MJ

更新日期：2020-04-27 00:00:00

abstract：OBJECTIVE:The potential use of bone marrow stromal cells (MSCs) as a cellular therapy for chronic cardiac diseases relies on the ability of the cell to replicate extensively in vitro and to give rise to myogenic cells that can replace the damaged cardiomyocytes. For this reason the present study investigated the replic...

journal_title：Cardiovascular research

authors： Liu Y,Song J,Liu W,Wan Y,Chen X,Hu C

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:Injury stimulates smooth muscle cell (SMC) migration and proliferation by mechanisms that are incompletely understood. Surgical preparative injury is an important determinant of neointimal thickening in human saphenous vein bypass grafts. We investigate here whether basement-membrane-degrading metalloprotein...

journal_title：Cardiovascular research

authors： George SJ,Zaltsman AB,Newby AC

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Anoxia followed by reoxygenation (A/R) increases endothelial cell superoxide (O2-) generation which is implicated in E-selectin overexpression. The mechanisms which govern these processes are not fully understood and therefore the goal of our study was to determine the functional importance of NADPH oxidase i...

journal_title：Cardiovascular research

authors： Rupin A,Paysant J,Sansilvestri-Morel P,Lembrez N,Lacoste JM,Cordi A,Verbeuren TJ

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:The mechanosensitive nonselective cation channel (NSC(MS)) and endothelin-1 (ET-1) play critical roles in the regulation of vascular tone. This study was undertaken to investigate the effect of ET-1 on NSC(MS) and on the myogenic response of arteries. METHODS:Cell-attached patch-clamp techniques were applied...

journal_title：Cardiovascular research

authors： Lee HA,Baek EB,Park KS,Jung HJ,Kim JI,Kim SJ,Earm YE

更新日期：2007-11-01 00:00:00

abstract：AIMS:The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression. However, recent reports indicate that high doses of capsaicin may c...

journal_title：Cardiovascular research

authors： Hiett SC,Owen MK,Li W,Chen X,Riley A,Noblet J,Flores S,Sturek M,Tune JD,Obukhov AG

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:This study examined the effects of diet-induced hypercholesterolemia on the extent of postischemic myocyte apoptosis and elucidated the potential mechanisms involved. Furthermore, the effects of rosiglitazone (RSG) on postischemic myocardial apoptosis in HC rabbits were investigated. METHODS:Male New Zealan...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Lopez BL,Christopher TA,Willette RN,Ohlstein EH,Yue TL,Ma XL

更新日期：2004-04-01 00:00:00

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:In pigs, the infarct size (IS) reduction achieved by a strong preconditioning stimulus (IPs) of 10 min ischemia and 15 min reperfusion is greater than that by a weaker preconditioning stimulus (IPw) of 3 min ischemia and 15 min reperfusion. The cardioprotection achieved by IPw is completely abolished by block...

journal_title：Cardiovascular research

authors： Gres P,Schulz R,Jansen J,Umschlag C,Heusch G

更新日期：2002-08-15 00:00:00

abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

journal_title：Cardiovascular research

authors： Vander Heide RS,Reimer KA

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:The Na+ activated K+ channel (IK(Na)) may be activated during ischaemia when the intracellular Na+ concentration is raised. As ischaemia is also associated with intracellular acidification, the influence of intracellular pH on this K+ channel was investigated. METHODS:The effects of intracellular Na+ and H+ ...

journal_title：Cardiovascular research

authors： Veldkamp MW,Vereecke J,Carmeliet E

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Angiotensin II stimulates vascular smooth muscle cell (VSMC) growth, and is considered to be an important mediator of intimal thickening after vascular injury. Recent evidence has indicated that VSMC apoptosis plays a major role in the response to balloon injury, and we therefore examined the effect of angiot...

journal_title：Cardiovascular research

authors： Holm AM,Andersen CB,Haunsø S,Hansen PR

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:Coronary microvascular endothelial cells (CMVEs) can modulate the contractile performance of the adjacent myocardium by the release of agents such as nitric oxide (NO). Most previous studies using CMVEs have been done in situ, in the intact organ. We set out to study possible differences in NO synthase (NOS)...

journal_title：Cardiovascular research

authors： Lang D,Bell JP,Bayraktutan U,Small GR,Shah AM,Lewis MJ

更新日期：1999-06-01 00:00:00

abstract：:Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

journal_title：Cardiovascular research

authors： Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

更新日期：2005-10-01 00:00:00

abstract：AIMS:We investigated the molecular mechanism of rapid-depolarization-induced atrial fibrosis. METHODS AND RESULTS:We used a direct atrial myocyte-fibroblast contact co-culture and a fibroblast-specific transforming growth factor β1 (TGF-β1), connective tissue growth factor (CTGF) and procollagen type I α-1 (COL1A1) lu...

journal_title：Cardiovascular research

authors： Tsai CT,Tseng CD,Hwang JJ,Wu CK,Yu CC,Wang YC,Chen WP,Lai LP,Chiang FT,Lin JL

更新日期：2011-03-01 00:00:00