Aldosterone and cardiac fibrosis: in vitro studies.

abstract：:To define the interactions between blood and endocardium damaged by lactic acid, the left ventricles of 48 isolated continuously perfused and beating hearts were exposed for 0-4 hours to Krebs Henseleit buffer (KHB) with or without 33 mumol.ml-1 of lactic acid (pH 6.4). After excising its apex, the left ventricle was ...

journal_title：Cardiovascular research

authors： Carter G,Gavin JB

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Ischaemic preconditioning may be mediated by oxygen free radicals generated during preconditioning. Conflicting results have been reported regarding the effect of superoxide dismutase (SOD) in attenuating the cardioprotective effect of preconditioning. The aim of the study was to reconcile this conflict by ex...

journal_title：Cardiovascular research

authors： Tanaka M,Fujiwara H,Yamasaki K,Sasayama S

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:This study investigated whether endothelial dysfunction occurs in mesenteric arteries of apoE-deficient mice and determined the role of endothelin (ET)-1, which is increased in human atherosclerosis, using an orally active endothelin ET(A) receptor antagonist. METHODS:ApoE-deficient and C57BL/6J control mice...

journal_title：Cardiovascular research

authors： d'Uscio LV,Barton M,Shaw S,Lüscher TF

更新日期：2002-02-01 00:00:00

abstract：:Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of c...

journal_title：Cardiovascular research

authors： Carey RA,Tipton CM,Lund DR

更新日期：1976-05-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is a risk factor independent of blood pressure; however, the mechanisms that distinguish pathological remodelling due to local cues from pressure overload are unresolved. This study was aimed at discovering a novel gene expression mechanism in heart failure. METHODS AND RESULTS:In angiotensin ...

journal_title：Cardiovascular research

authors： Yue H,Li W,Desnoyer R,Karnik SS

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the site in the coronary microcirculation that is dilated by an ATP sensitive potassium channel opener, levcromakalim, and to examine whether the magnitude of dilatation is size dependent. METHODS:Coronary arterial microvessels were observed through an intravital microscope equipped wi...

journal_title：Cardiovascular research

authors： Sato K,Kanatsuka H,Sekiguchi N,Akai K,Wang Y,Sugimura A,Kumagai T,Komaru T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive he...

journal_title：Cardiovascular research

authors： Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JM

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex with the ryanodine receptor (Ca(2+) release channel), triadin, and calsequestrin. METHODS:To better understand the role of junctin in excitation-contraction coupling in the heart, we genera...

journal_title：Cardiovascular research

authors： Kirchhefer U,Neumann J,Bers DM,Buchwalow IB,Fabritz L,Hanske G,Justus I,Riemann B,Schmitz W,Jones LR

更新日期：2003-08-01 00:00:00

abstract：:The intrinsic ability of resistance arteries to respond to transmural pressure is the single most important determinant of their function. Despite an ever-growing catalogue of signalling pathways that underlie the myogenic response, it remains an enigmatic mechanism. The myogenic response's mechanistic diversity has l...

journal_title：Cardiovascular research

authors： Lidington D,Schubert R,Bolz SS

更新日期：2013-03-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is characterized by a shift in metabolic substrate utilization, but the molecular events underlying the metabolic remodelling remain poorly understood. We explored metabolic remodelling and mitochondrial dysfunction in cardiac hypertrophy and investigated the cardioprotective effects of choline...

journal_title：Cardiovascular research

authors： Xu M,Xue RQ,Lu Y,Yong SY,Wu Q,Cui YL,Zuo XT,Yu XJ,Zhao M,Zang WJ

更新日期：2019-03-01 00:00:00

abstract：:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogeno...

journal_title：Cardiovascular research

authors： Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DM

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the roles of left atrial pressure and ventricular function in the determination of early diastolic filling. METHODS:Various grades of ventricular dysfunction were made in 12 mongrel dogs by coronary microembolization under pentobarbitone anaesthesia. Left atrial pressure was altered by...

journal_title：Cardiovascular research

authors： Nakatani S,Beppu S,Miyatake K,Nimura Y

更新日期：1992-02-01 00:00:00

abstract：:The structural nature of fibrillar collagen involved in the replacement fibrosis which accompanies discrete areas of cell necrosis remains uncertain, as does its influence on the diastolic and systolic stiffness of the intact myocardium. This study, using 15 micron diameter microsphere embolisation of the rat myocardi...

journal_title：Cardiovascular research

authors： Carroll EP,Janicki JS,Pick R,Weber KT

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...

journal_title：Cardiovascular research

authors： Li HF,Chen SA,Wu SN

更新日期：2000-03-01 00:00:00

abstract：:It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac C...

journal_title：Cardiovascular research

authors： Gros D,Dupays L,Alcoléa S,Meysen S,Miquerol L,Théveniau-Ruissy M

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:I(Ks), the slow component of the delayed rectifier potassium current, underlies a strong beta-adrenergic regulation in the heart. Catecholamines, like isoproterenol, induce a strong increase in I(Ks). Recent work has pointed to an opposing biological effect of beta(1)- and beta(3)-adrenoceptors in the heart....

journal_title：Cardiovascular research

authors： Bosch RF,Schneck AC,Kiehn J,Zhang W,Hambrock A,Eigenberger BW,Rüb N,Gogel J,Mewis C,Seipel L,Kühlkamp V

更新日期：2002-12-01 00:00:00

abstract：:To investigate cardiovascular changes in experimental acromegaly, a growth hormone-secreting tumour (MtT-W-15) was implanted in adult female rats. Somatic and tumour growth occurred steadily during the 8 week study period, as did an increase in serum growth hormone titre. Weight of left ventricle and right ventricle i...

journal_title：Cardiovascular research

authors： Penney DG,Dunbar JC Jr,Baylerian MS

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS:Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, ...

journal_title：Cardiovascular research

authors： Jerkic M,Rodríguez-Barbero A,Prieto M,Toporsian M,Pericacho M,Rivas-Elena JV,Obreo J,Wang A,Pérez-Barriocanal F,Arévalo M,Bernabéu C,Letarte M,López-Novoa JM

更新日期：2006-03-01 00:00:00

abstract：AIMS:Caveolae are membrane microdomains where important signalling pathways are assembled and molecular effects transduced. In this study, we hypothesized that shear stress-mediated vasodilation (SSD) of mouse small coronary arteries (MCA) is caveolae-dependent. METHODS AND RESULTS:MCA (80-150 μm) isolated from wild-t...

journal_title：Cardiovascular research

authors： Chai Q,Wang XL,Zeldin DC,Lee HC

更新日期：2013-10-01 00:00:00

abstract：:The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage determination have been a focus of intense interest, and have been investigated in various systems. Etv2/Etsrp71/ER71 is such a factor that is both necessary and sufficient for the development of haematopoietic and endothelial...

journal_title：Cardiovascular research

authors： Koyano-Nakagawa N,Garry DJ

更新日期：2017-09-01 00:00:00

abstract：:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

journal_title：Cardiovascular research

authors： Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

journal_title：Cardiovascular research

authors： Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

更新日期：1995-08-01 00:00:00

abstract：:To improve assessment of ventricular function during cardiac catheterisation there should be available a continuous registration of stroke volume and cardiac output in addition to ventricular pressure. To obtain the desired volumetric quantities a catheter has been developed which measures changes in intraventricular ...

journal_title：Cardiovascular research

authors： Baan J,Jong TT,Kerkhof PL,Moene RJ,van Dijk AD,van der Velde ET,Koops J

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:Cholinergic vasodilation has been thought to play little if any role in the regulation of blood pressure in humans. Autonomic denervation potentiates the vasoconstriction evoked by nitric oxide synthase inhibition in humans, but the mechanism is unclear. We hypothesized that this may be related to loss of neu...

journal_title：Cardiovascular research

authors： Lepori M,Sartori C,Duplain H,Nicod P,Scherrer U

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the ventricular expression of brain natriuretic peptide (BNP) in the transplanted human heart. METHODS:Serial right ventricular biopsies (n = 68) and plasma samples (n = 68) were obtained for measurement of BNP and atrial natriuretic peptide (ANP) from 14 orthotopic cardiac transplant ...

journal_title：Cardiovascular research

authors： Ationu A,Burch M,Singer D,Littleton P,Carter N

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situati...

journal_title：Cardiovascular research

authors： Hale SL,Kloner RA

更新日期：1998-12-01 00:00:00

abstract：AIMS:KCNQ1 (alias KvLQT1 or Kv7.1) and KCNE1 (alias IsK or minK) co-assemble to form the voltage-activated K(+) channel responsible for I(Ks)-a major repolarizing current in the human heart-and their dysfunction promotes cardiac arrhythmias. The channel is a component of larger macromolecular complexes containing known...

journal_title：Cardiovascular research

authors： Nicolas CS,Park KH,El Harchi A,Camonis J,Kass RS,Escande D,Mérot J,Loussouarn G,Le Bouffant F,Baró I

更新日期：2008-08-01 00:00:00

abstract：AIMS:Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and at...

journal_title：Cardiovascular research

authors： Katare R,Oikawa A,Cesselli D,Beltrami AP,Avolio E,Muthukrishnan D,Munasinghe PE,Angelini G,Emanueli C,Madeddu P

更新日期：2013-01-01 00:00:00

abstract：AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II...

journal_title：Cardiovascular research

authors： Cooper HA,Cicalese S,Preston KJ,Kawai T,Okuno K,Choi ET,Kasahara S,Uchida HA,Otaka N,Scalia R,Rizzo V,Eguchi S

更新日期：2020-05-08 00:00:00

abstract：BACKGROUND:Plasma low density lipoproteins (LDL) play a key role in the pathogenesis of atherosclerosis. LDL modify gene expression in vascular cells leading to disturbances in the functional state of the vessel wall. METHODS:Expression levels of C-4 sterol methyl oxidase gene (ERG25), sterol regulatory element bindin...

journal_title：Cardiovascular research

authors： Rodriguez C,Raposo B,Martínez-González J,Llorente-Cortés V,Vilahur G,Badimon L

更新日期：2003-04-01 00:00:00