Abstract:
OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive heart failure (CHF). METHODS:CHF was induced in rats by coronary artery ligation. Sham-operated rats served as normal controls. Plasma ADMA was determined by high performance liquid chromatography with fluorescence detection. Glomerular filtration rate (GFR) and renal blood flow (RBF) were measured by the clearance of inulin and p-aminohippuric acid, respectively. Endothelial function of the aorta was assessed in an organ bath. RESULTS:Plasma levels of ADMA in rats with CHF (0.94 +/- 0.05 mumol/l) were significantly increased compared with sham-operated controls (0.75 +/- 0.06 mumol/l, p < 0.05). Plasma levels of ADMA was negatively correlated with GFR (r = -0.65, p < 0.05). Decreased endothelium-dependent relaxation to acetylcholine in the aorta of CHF was completely restored by L-arginine (300 microM) (p < 0.01) while endothelium-independent relaxation to nitroprusside was not altered. ADMA potently inhibited endothelium-dependent relaxation in thoracic aorta of normal and CHF rats. The effect of ADMA was completely antagonized by L-arginine in both groups (p < 0.01). Moreover, L-arginine improved endothelium-dependent relaxation in CHF rats in the presence of ADMA. CONCLUSIONS:An endogenous NO synthesis inhibitor ADMA is increased in the circulation of rats with CHF. The increased plasma levels of ADMA may contribute to the decreased endothelium-dependent relaxation in CHF, which is restored by L-arginine, possibly by competitive antagonism of ADMA.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JMdoi
10.1016/s0008-6363(97)00242-3subject
Has Abstractpub_date
1998-03-01 00:00:00pages
667-75issue
3eissn
0008-6363issn
1755-3245pii
S0008-6363(97)00242-3journal_volume
37pub_type
杂志文章abstract::The voltage- and rate-dependence of the depression of the maximum rate of depolarisation (Vmax) by therapeutic concentrations of flecainide and lorcainide were studied in guinea-pig ventricle by standard microelectrode techniques. At normal resting potentials the drugs produced only minor depression of Vmax in the abs...
journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/17.5.251
更新日期:1983-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/21.5.337
更新日期:1987-05-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2006-09-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2005-05-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/cvu029
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/13.12.693
更新日期:1979-12-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/cvs204
更新日期:2012-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00089-9
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/27.7.1209
更新日期:1993-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2006.05.023
更新日期:2006-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvs164
更新日期:2012-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/11.6.568
更新日期:1977-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00207-2
更新日期:1999-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00220-5
更新日期:1999-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00856-8
更新日期:2003-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00239-4
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pub_type: 杂志文章
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doi:10.1016/s0008-6363(00)00320-5
更新日期:2001-04-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1016/s0008-6363(97)00191-0
更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-10-15 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/11.3.210
更新日期:1977-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00437-6
更新日期:2002-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(95)00181-6
更新日期:1995-12-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(00)00063-8
更新日期:2000-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/28.2.270
更新日期:1994-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/28.6.847
更新日期:1994-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvw049
更新日期:2016-06-01 00:00:00