Abstract：
:This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14C lysine into cardiac myosin, were compared with the pattern found in suitably matched controls. A significant increase in RNA, hydroxyproline, and 14C incorporation was observed in SHRs. Antihypertensive treatment caused reversal of hypertrophy and normalization of all biochemical parameters except hydroxyproline, the concentration of which increased significantly as myocardial weight decreased. These compositional changes may help explain the conflicting result of the haemodynamic effects of cardiac hypertrophy.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Sen S,Tarazi RC,Bumpus FMdoi
10.1093/cvr/10.2.254subject
Has Abstractpub_date
1976-03-01 00:00:00pages
254-61issue
2eissn
0008-6363issn
1755-3245journal_volume
10pub_type
杂志文章abstract：AIMS:A cytosolic calcium (Ca(2+)(i)) increase is an important activation signal for the endothelium. We investigated whether interendothelial spreading of the Ca(2+) signal via gap junctions (GJs) plays a role for the overall Ca(2+)(i) increase in response to vasoactive agonists. METHODS AND RESULTS:In human umbilical...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvr345
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2005.08.003
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of aging on left ventricular (LV) geometry, collagen levels, matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) abundance, and myocardial fibroblast function. METHODS:Young (3-month-old; n=28), middle-aged (MA; 15-month-old; n=17), and old (23-month-old; n...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2004.11.029
更新日期：2005-05-01 00:00:00
abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvu033
更新日期：2014-04-01 00:00:00
abstract：:The cardiospecificity of the MB isoenzyme of creatine kinase, EC 2.7.3.2, (CK) with its associated diagnostic and research value has resulted in the development of a number of procedures for the separation and quantitation of the three isoenzymes of CK. In our experience methods involving cellulose acetate electrophor...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/11.2.94
更新日期：1977-03-01 00:00:00
abstract：:Tension and action potentials have been measured simultaneously from isolated cat papillary muscles. Two groups of experiments are described. In the first group, the external conditions under which the muscle contracted were changed. Specifically, stimulation rate, extra-cellular [Ca++], extracellular [Na++] were alte...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/11.3.210
更新日期：1977-05-01 00:00:00
abstract：OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Major advances in molecular biology over the past decade have increased our understanding of how genes are expressed and regulated in mammalian cells in vivo. This knowledge has been translated to investigations of the molecular and cellular biology of the cardiovascular system. Gene transfer, the introduction of a re...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/28.4.445
更新日期：1994-04-01 00:00:00
abstract：:Cardiomyocytes express a surprisingly large number of potassium channel types. The primary physiological functions of the currents conducted by these channels are to maintain the resting membrane potential and mediate action potential repolarization under basal conditions and in response to changes in the concentratio...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvaa068
更新日期：2020-07-15 00:00:00
abstract：OBJECTIVES:Recombinant retroviral vectors have been shown to be useful tools for marking cells so as to follow their fates during development. The aim of this study was to determine the utility and advantages of an adenoviral vector as a tool to study the heart as it develops from a simple tube into a complex four-cham...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Clinical trials suggest that sotalol and dofetilide are much more effective in preventing atrial fibrillation (AF) than in terminating it. This study evaluated potential mechanisms of discordant sotalol and dofetilide effects on AF termination vs. prevention. METHODS:We applied 240-electrode epicardial mapp...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(00)00320-5
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVES:The aim was to determine the effect and mechanisms by which myocyte stretch interacts with the prolongation of action potential duration (APD) by the class III antiarrhythmic agent E-4031. METHODS:Action potentials and whole-cell currents were measured in isolated guinea pig ventricular myocytes with a patc...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Papillary muscles isolated from the left ventricle of 17-20 day old Syrian hamsters with genetic cardiomyopathy (BIO 14.6 strain) were examined for their mechanophysiological response to the beta adrenoceptor agonist isoprenaline. The indices of isometric twitch for both myopathic and aged matched normal (BIO RB strai...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.8.609
更新日期：1986-08-01 00:00:00
abstract：BACKGROUND:In the myocardium, myocyte cell division is irreversibly blocked shortly after birth. The signal that initiates cell cycle withdrawal is unknown. The purpose of this study was to relate changes in expression of beta1 integrin and its associated alpha subunits to cardiomyocyte cell cycle progression during th...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(00)00140-1
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/28.7.1049
更新日期：1994-07-01 00:00:00
abstract：:The rate of QT adaptation to abrupt changes in pacing rate was studied in seven patients with newly diagnosed complete heart block with a ventricular escape rate of less than 40 beats.min-1. Their median age was 70 (range 36-84) years, and none was taking any cardioactive medication known to affect the QT interval. Fr...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/22.1.67
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To investigate the cellular mechanisms underlying global and regional LV dysfunction in the post-infarct (MI) remodeled rat hearts. METHODS:LV remodeling and function were quantified by echocardiography, morphometry, in vivo hemodynamics, and isolated perfused heart studies in 6 weeks post-MI and sham-operat...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(00)00160-7
更新日期：2000-10-01 00:00:00
abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvm107
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX). METHODS:We investigated the consequences of increased expre...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2003.08.006
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:The aim was to correlate the relative abilities of amiodarone, lignocaine, and penticainide in suppressing ventricular tachyarrhythmias in response to coronary artery occlusion with their relative abilities to prolong ventricular functional refractory periods and to reduce intraventricular conduction velociti...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/26.11.1116
更新日期：1992-11-01 00:00:00
abstract：AIMS:Dilated cardiomyopathy (DCM) is characterized by ventricular dilation associated with systolic dysfunction, which could be caused by mutations in lamina/C gene (LMNA). LMNA-linked DCM is severe in males in both human patients and a knock-in mouse model carrying a homozygous p.H222P mutation (LmnaH222P/H222P). The ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvt106
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:We determine if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. METHODS:We determined the effect of the weakly vasodilating KATP opener, BMS-180448...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：AIMS:Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR). RyR type 1 or type 2 was prepared from rabbit skeletal muscle or pig cardiac muscle, respectively. In heart failure,...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvp273
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2004.10.019
更新日期：2005-02-15 00:00:00
abstract：:Exaggerated cardiovascular responsiveness is common in young men and may cause non-specific symptoms and poor performance. Conventional autonomic function tests are not clinically useful. We have therefore designed a thermal entrainment method to evaluate sympathetic and parasympathetic cardiovascular function in subj...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/23.3.262
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evalua...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(98)00152-7
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death. METHODS:Isolated arterially perfused rabbit papillary muscles and septa were suspended in a control...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.4.294
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether alpha 1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the ne...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/0008-6363(95)00216-2
更新日期：1996-02-01 00:00:00
abstract：AIMS:Human congenital heart disease linked to mutations in the homeobox transcription factor, NKX2-5, is characterized by cardiac anomalies, including atrial and ventricular septal defects as well as conduction and occasional defects in contractility. In the mouse, homozygous germline deletion of Nkx2-5 gene results in...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvr037
更新日期：2011-07-15 00:00:00
