Antiarrhythmic and electrophysiological effects of amiodarone, lignocaine, and penticainide in anaesthetised rats.

abstract：OBJECTIVE:The pulmonary circulation may contribute to elevated plasma levels of endothelin-1 (ET-1) in congestive heart failure (CHF). The aims of the present study were to determine the mechanisms of increased secretion of ET-1 from the pulmonary circulation in CHF. METHODS:Juvenile pigs were subjected to sham operat...

journal_title：Cardiovascular research

authors： von Lueder TG,Kjekshus H,Edvardsen T,ØIe E,Urheim S,Vinge LE,Ahmed MS,Smiseth OA,Attramadal H

更新日期：2004-07-01 00:00:00

abstract：:Cardiac hypertrophy occurs in a number of disease states associated with chronic increases in cardiac work load. Although cardiac hypertrophy may initially represent an adaptive response of the myocardium, ultimately, it often progresses to ventricular dilatation and heart failure. Much investigation has focused on th...

journal_title：Cardiovascular research

authors： Fiedler B,Wollert KC

更新日期：2004-08-15 00:00:00

abstract：:One of the obstacles to a better understanding of the pathogenesis of human cardiomyopathies has been poor availability of heart-tissue samples at early stages of disease development. This has possibly changed by the advent of patient-derived induced pluripotent stem cell (hiPSC) from which cardiomyocytes can be deriv...

journal_title：Cardiovascular research

authors： Eschenhagen T,Mummery C,Knollmann BC

更新日期：2015-04-01 00:00:00

abstract：AIMS:Levels of circulating CD14(high)CD16(+) monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16(+) phenotype by classical CD14(high)CD16(-) cells. We tested the hypothesis that a...

journal_title：Cardiovascular research

authors： Layne K,Di Giosia P,Ferro A,Passacquale G

更新日期：2016-07-01 00:00:00

abstract：:The effects of both gradual and abrupt coronary occlusion on regional wall function (sonomicrometry) and left ventricular relaxation were studied in the intact dog heart. The ischaemic dysfunction observed in the two interventions as assessed by pressure-length loops showed considerably different patterns. The regiona...

journal_title：Cardiovascular research

authors： Doyle RL,Foëx P,Ryder WA,Jones LA

更新日期：1987-07-01 00:00:00

abstract：AIMS:In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROS production in fat may attenuate the metabolic syndrome. Activation of mineralocorticoid receptor (MR) promotes inflammation ...

journal_title：Cardiovascular research

authors： Hirata A,Maeda N,Hiuge A,Hibuse T,Fujita K,Okada T,Kihara S,Funahashi T,Shimomura I

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:We, and others, have previously reported a strong correlation between increased inter-ventricular dispersion of repolarization and the occurrence of fatal arrhythmia in animal models of CHF. The existence of this and other such distinct electrophysiologic phenotypes in right (RV) vs. left ventricles (LV) cou...

journal_title：Cardiovascular research

authors： Chugh SS,Whitesel S,Turner M,Roberts CT Jr,Nagalla SR

更新日期：2003-02-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is a risk factor independent of blood pressure; however, the mechanisms that distinguish pathological remodelling due to local cues from pressure overload are unresolved. This study was aimed at discovering a novel gene expression mechanism in heart failure. METHODS AND RESULTS:In angiotensin ...

journal_title：Cardiovascular research

authors： Yue H,Li W,Desnoyer R,Karnik SS

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The presence is well established in unstable angina of intracoronary thrombosis in a stenosed epicardial coronary artery. The effects of the thrombus formation on the distal microcirculation are however still unclear. METHODS:We adapted the Folts canine model of left circumflex coronary arterial stenosis and...

journal_title：Cardiovascular research

authors： Mansaray M,Belcher PR,Vergroesen I,Wright ZM,Hynd JW,Drake-Holland AJ,Noble MI

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-)). METHODS:Nineteen adult annexin A7(-/-) and 14 wild-type m...

journal_title：Cardiovascular research

authors： Schrickel JW,Brixius K,Herr C,Clemen CS,Sasse P,Reetz K,Grohé C,Meyer R,Tiemann K,Schröder R,Bloch W,Nickenig G,Fleischmann BK,Noegel AA,Schwinger RH,Lewalter T

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To investigate the physiological role of cAMP-dependent protein kinase A (PKA)-mediated, cardiac myosin binding protein C (MyBP-C) phosphorylation. METHODS:A cardiac MyBP-C cDNA lacking nine amino acids, which contained a phosphorylation site, was made, and subsequently used to generate multiple lines of tra...

journal_title：Cardiovascular research

authors： Yang Q,Hewett TE,Klevitsky R,Sanbe A,Wang X,Robbins J

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism. METHODS:Small intrapulmonary arteries (IPA) from rats were mounted on a myograph and PGF2alpha (3 microM)-induced tension recorded before and 40...

journal_title：Cardiovascular research

authors： Vanková M,Snetkov VA,Knock GA,Aaronson PI,Ward JP

更新日期：2005-02-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：:Congestive heart failure may be deemed the epidemic of cardiology in the 21st century in the industrialized part of the world. Although new therapies improving morbidity and mortality from chronic heart failure have emerged it is likely that there is a growing role for digoxin. Thus, digoxin treatment is known to cont...

journal_title：Cardiovascular research

authors： Kjeldsen K,Nørgaard A,Gheorghiade M

更新日期：2002-09-01 00:00:00

abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

journal_title：Cardiovascular research

authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performa...

journal_title：Cardiovascular research

authors： Tyni-Lenné R,Jansson E,Sylvén C

更新日期：1999-04-01 00:00:00

abstract：AIMS:Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction HFrEF, and to elucidate the underlying mechanisms. METHODS AND RESULT...

journal_title：Cardiovascular research

authors： Røe ÅT,Ruud M,Espe EK,Manfra O,Longobardi S,Aronsen JM,Nordén ES,Husebye T,Kolstad TRS,Cataliotti A,Christensen G,Sejersted OM,Niederer SA,Andersen GØ,Sjaastad I,Louch WE

更新日期：2019-03-15 00:00:00

abstract：OBJECTIVES:This study examined the effects of diet-induced hypercholesterolemia on the extent of postischemic myocyte apoptosis and elucidated the potential mechanisms involved. Furthermore, the effects of rosiglitazone (RSG) on postischemic myocardial apoptosis in HC rabbits were investigated. METHODS:Male New Zealan...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Lopez BL,Christopher TA,Willette RN,Ohlstein EH,Yue TL,Ma XL

更新日期：2004-04-01 00:00:00

abstract：:Controversy exists as to whether the diabetic heart is more or less sensitive to ischemic injury. Although a considerable number of experimental studies have directly determined the effects of ischemia on the diabetic heart, there is still no general agreement as to whether metabolic changes within the myocardium cont...

journal_title：Cardiovascular research

authors： Feuvray D,Lopaschuk GD

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect of increased left ventricular filling pressure on the pulmonary vein flow (PVQ) pattern. METHODS:Pulmonary vein flow was recorded using an ultrasonic transit time flow meter in six anaesthetised dogs. Mean left atrial pressure was increased by stepwise volume loading fro...

journal_title：Cardiovascular research

authors： Smiseth OA,Lødemel K,Riddervold F,Blaha M

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Myocardial cellular electrophysiology and intracellular Ca2+ regulation are altered in heart failure. The extent of these changes may vary within the layers of the ventricular wall. To examine this, cell size, action potential and intracellular Ca2+ transient characteristics (Fura-2) were measured in single c...

journal_title：Cardiovascular research

authors： McIntosh MA,Cobbe SM,Smith GL

更新日期：2000-01-14 00:00:00

abstract：:To evaluate the effect of beta blockade on energy metabolism in ischaemic myocardium metoprolol tartrate in doses of 0.2 or 0.5 mg.kg-1 or saline was injected into 24 anaesthetised dogs 20 min after coronary ligation. Regional myocardial blood flow was measured by the hydrogen gas clearance method, and the heart rate ...

journal_title：Cardiovascular research

authors： Nanki M,Itoh K,Matsubara T,Nishimura K,Kambe T,Sugiyama S,Ozawa T,Sakamoto N

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:Responses to EDHF are usually characterised in the presence of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibitors. The contribution of NO to endothelium-dependent relaxation in the presence of NOS inhibitors was assessed using NO scavengers with the objective of testing (i) whether any residual ...

journal_title：Cardiovascular research

authors： Chauhan S,Rahman A,Nilsson H,Clapp L,MacAllister R,Ahluwalia A

更新日期：2003-01-01 00:00:00

abstract：AIMS:This study examines the effect of endogenous male sex hormones on thromboxane A2 (TXA2), prostaglandin (PG) I2, PGF(2 alpha), and PGE I2 release, as well as their role in acetylcholine (ACh)-mediated relaxation in the aorta. METHODS AND RESULTS:Aortic segments from orchidectomized and control male Sprague-Dawley ...

journal_title：Cardiovascular research

authors： Martorell A,Blanco-Rivero J,Aras-López R,Sagredo A,Balfagón G,Ferrer M

更新日期：2008-02-01 00:00:00

abstract：AIMS:Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may h...

journal_title：Cardiovascular research

authors： Martorell J,Santomá P,Kolandaivelu K,Kolachalama VB,Melgar-Lesmes P,Molins JJ,Garcia L,Edelman ER,Balcells M

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:It has been proposed that human immunodeficiency virus (HIV) infection-induced inflammatory environment may contribute to the pathogenesis of cardiovascular diseases. Recent studies have also demonstrated the potential role of estrogen as therapeutic agents in the prevention or treatment of cardiovascular dis...

journal_title：Cardiovascular research

authors： Lee YW,Eum SY,Nath A,Toborek M

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Automatic analysis of the frequency content of the fibrillatory baseline on the surface ECG accurately reflects the average rate of atrial fibrillation (AF). This frequency measurement correlates with the behavior of AF and predicts the response to administration of ibutilide, a new antiarrhythmic drug. Neith...

journal_title：Cardiovascular research

authors： Bollmann A,Sonne K,Esperer HD,Toepffer I,Langberg JJ,Klein HU

更新日期：1999-10-01 00:00:00

abstract：:The effect on the microcirculation of long term administration of the alpha 1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg.litre-1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity ...

journal_title：Cardiovascular research

authors： Dawson JM,Hudlická O

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...

journal_title：Cardiovascular research

authors： McIlroy M,O'Rourke M,McKeown SR,Hirst DG,Robson T

更新日期：2006-01-01 00:00:00

abstract：:Myocardial lactate content and simultaneous evolution of a lactate arteriovenous gradient associated with incomplete obstruction of the left coronary bed were studied in dog hearts. Samples of blood were taken from a peripheral artery and the coronary sinus; transmural samples of myocardial tissue were obtained from t...

journal_title：Cardiovascular research

authors： Al Makdessi S,Andrieu JL,Chah QT,Tuduri AJ,Faucon G

更新日期：1982-10-01 00:00:00