当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.

Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.

Abstract：

AIMS:Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may help understand the progression of occlusive arterial disease, providing insights into how to mitigate adverse responses in specific settings and individuals. METHODS AND RESULTS:Vascular architectures mimicking coronary and carotid bifurcations were derived from clinical imaging and used to generate conjoint computational meshes for in silico analysis and biocompatible scaffolds for in vitro models. In parallel with three-dimensional flow simulations, geometrically realistic scaffolds were seeded with human smooth muscle cells (SMC) or endothelial cells and exposed to relevant, physiological flows. In vitro surrogates of endothelial health, atherosclerotic progression, and thrombosis were locally quantified and correlated best with an quantified extent of flow recirculation occurring within the bifurcation models. Oxidized low-density lipoprotein uptake, monocyte adhesion, and tissue factor expression locally rose up to three-fold, and phosphorylated endothelial nitric oxide synthase and Krüppel-like factor 2 decreased up to two-fold in recirculation areas. Isolated testing in straight-tube idealized constructs subject to static, oscillatory, and pulsatile conditions, indicative of different recirculant conditions corroborated these flow-mediated dependencies. CONCLUSIONS:Flow drives variations in vascular reactivity and vascular beds. Endothelial health was preserved by arterial flow but jeopardized in regions of flow recirculation in a quasi-linear manner. Similarly, SMC exposed to flow were more thrombogenic in large recirculating regions. Health, thrombosis, and atherosclerosis biomarkers correlate with the extent of recirculation in vascular cells lining certain vascular geometries.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Martorell J,Santomá P,Kolandaivelu K,Kolachalama VB,Melgar-Lesmes P,Molins JJ,Garcia L,Edelman ER,Balcells M

doi

10.1093/cvr/cvu124

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

37-46

issue

1

eissn

0008-6363

issn

1755-3245

pii

cvu124

journal_volume

103

pub_type

杂志文章

相关文献

CARDIOVASCULAR RESEARCH文献大全
  • Cardiac genomic response following preconditioning stimulus.

    abstract：:This review focuses on the genomic response following a preconditioning stimulus. Initial studies demonstrated that classical ischemic preconditioning mediated by cyclic episodes of short durations of reversible ischemia and reperfusion could result in the reprogramming of gene expression. Some of these genes are tran...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2006.02.023

    authors： Das DK,Maulik N

    更新日期：2006-05-01 00:00:00

  • In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts.

    abstract：OBJECTIVE:Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin in myocardium increased cardiac relaxation in vitro as well as in vivo. Therefore, the objective of this study is to test...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.06.028

    authors： Schmidt U,Zhu X,Lebeche D,Huq F,Guerrero JL,Hajjar RJ

    更新日期：2005-05-01 00:00:00

  • Influence of ivabradine on reverse remodelling during mechanical unloading.

    abstract：AIMS:Ivabradine (Iva) has shown beneficial structural and functional effects in clinical and experimental heart failure (HF), but its action in combination with mechanical unloading (MU), such as during treatment with left ventricular assist devices (LVAD), is unknown. The aim of this study was to investigate the effec...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvs318

    authors： Navaratnarajah M,Ibrahim M,Siedlecka U,van Doorn C,Shah A,Gandhi A,Dias P,Sarathchandra P,Yacoub MH,Terracciano CM

    更新日期：2013-02-01 00:00:00

  • Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity.

    abstract：:Circulating concentrations of leucocyte elastase and free radical activity were measured in 11 adults undergoing cardiopulmonary bypass. In all patients the bypass procedure was associated with pronounced changes in plasma elastase concentrations, and peak enzyme concentrations correlated closely with the duration of ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/22.1.37

    authors： Hind CR,Griffin JF,Pack S,Latchman YE,Drake HF,Jones HM,Brostoff J,Dormandy TL,Treasures T

    更新日期：1988-01-01 00:00:00

  • A1 receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia.

    abstract：OBJECTIVE:The aim was to test the hypothesis that A1 receptor mediated cardioprotection by endogenous adenosine is exerted during ischaemia rather than reperfusion. METHODS:Anaesthetised open chest rabbits were subjected to 30 min regional ischaemia and 120 min reperfusion, and randomised to one of six groups: group I...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/28.2.270

    authors： Zhao ZQ,Nakanishi K,McGee DS,Tan P,Vinten-Johansen J

    更新日期：1994-02-01 00:00:00

  • Oxygen radical scavenging agents as adjuvant therapy with tissue plasminogen activator in a canine model of coronary thrombolysis.

    abstract：OBJECTIVES:Early thrombolysis can reduce infarct size and enhance the long term recovery of contractile function after acute myocardial infarction. These benefits of early reperfusion may be confounded, however, by platelet mediated reocclusion after initial lysis, and "reperfusion injury" mediated by oxygen derived fr...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/27.6.925

    authors： Przyklenk K,Kloner RA

    更新日期：1993-06-01 00:00:00

  • Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.

    abstract：OBJECTIVE:We determine if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. METHODS:We determined the effect of the weakly vasodilating KATP opener, BMS-180448...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Grover GJ,D'Alonzo AJ,Hess T,Sleph PG,Darbenzio RB

    更新日期：1995-11-01 00:00:00

  • Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

    abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvs271

    authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

    更新日期：2012-12-01 00:00:00

  • Pharmacological characterisation of a re-entry model for atrial tachycardia in conscious dogs.

    abstract：:We studied the effects of intravenously administered autonomic agents, the calcium channel blocker diltiazem, and Class I and III anti-arrhythmic agents on a re-entry model for atrial tachycardia in seven conscious dogs. The model was created by a Y-shaped incision in the intercaval region and front free wall of the r...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/23.5.400

    authors： Wu KM,Hunter T,Proakis A

    更新日期：1989-05-01 00:00:00

  • Controversies regarding hormone therapy: Insights from inflammation and hemostasis.

    abstract：:Many observational studies and experimental and animal studies have demonstrated that estrogen therapy (ET) or hormone therapy (HT) significantly reduces the risk of coronary heart disease. Nonetheless, recent randomized controlled trials and the Nurses' Health Study in secondary prevention demonstrate trends toward a...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2005.12.004

    authors： Koh KK,Yoon BK

    更新日期：2006-04-01 00:00:00

  • Noninvasive determination of the mitral valve area in stenosis: a computational model and correlation with autopsy and open heart measurements.

    abstract：:An analytical formulation has been developed which allows the computation of mitral valve area (A) from the potentially noninvasive paramaeters of hear rate (R), cardiac output (CO) and diastolic filling period (DFP) by the equation A = 21 CO/R x DFP2. The computed areas correlate with autopsy and open heart measureme...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/14.4.223

    authors： Seitz WS,Operschall EJ

    更新日期：1980-04-01 00:00:00

  • Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

    abstract：AIMS:Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein phosphorylation, but the underlying mechanisms remain unclear. This is due to a lack of investigation into the local, rather than global, regulation of PP...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu123

    authors： Chiang DY,Li N,Wang Q,Alsina KM,Quick AP,Reynolds JO,Wang G,Skapura D,Voigt N,Dobrev D,Wehrens XH

    更新日期：2014-07-01 00:00:00

  • Effect of glyceryl trinitrate on peripheral arteries alters left ventricular hydraulic load in man.

    abstract：:Effects of sublingual glyceryl trinitrate (GTN) were studied in ten patients without heart failure during diagnostic cardiac catheterisation following angiography. GTN caused substantial reduction in peak left ventricular and aortic pressure (19 mmHg) with lesser reduction in mean aortic pressure (9 mmHg) and no chang...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/20.2.153

    authors： Yaginuma T,Avolio A,O'Rourke M,Nichols W,Morgan JJ,Roy P,Baron D,Branson J,Feneley M

    更新日期：1986-02-01 00:00:00

  • Matrix metalloproteinase-3 and coronary remodelling: implications for unstable coronary disease.

    abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2007.05.003

    authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

    更新日期：2007-09-01 00:00:00

  • Phosphodiesterase 5 inhibitors: are they cardioprotective?

    abstract：:A growing body of animal studies provides evidence for potential cardioprotective effects of inhibitors of the enzyme phosphodiesterase isoform 5. Infarct size reduction by administration of phosphodiesterase 5 inhibitors was described in various experimental models of ischaemia and reperfusion. Furthermore, potential...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvp170

    authors： Reffelmann T,Kloner RA

    更新日期：2009-07-15 00:00:00

  • Integrative genomics in cardiovascular medicine.

    abstract：:Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvs303

    authors： Ware JS,Petretto E,Cook SA

    更新日期：2013-03-15 00:00:00

  • Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.

    abstract：AIMS:The cAMP-dependent protein kinase (PKA) mediates β-adrenoceptor (β-AR) regulation of cardiac contraction and gene expression. Whereas PKA activity is well characterized in various subcellular compartments of adult cardiomyocytes, its regulation in the nucleus remains largely unknown. The aim of the present study w...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu029

    authors： Haj Slimane Z,Bedioune I,Lechêne P,Varin A,Lefebvre F,Mateo P,Domergue-Dupont V,Dewenter M,Richter W,Conti M,El-Armouche A,Zhang J,Fischmeister R,Vandecasteele G

    更新日期：2014-04-01 00:00:00

  • Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs.

    abstract：:Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/9.1.47

    authors： Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

    更新日期：1975-01-01 00:00:00

  • Effect of acetylcholine on aconitine induced delayed afterdepolarisation in the frog atrium and ventricle.

    abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/21.11.804

    authors： Sawanobori T,Hirano Y,Hiraoka M

    更新日期：1987-11-01 00:00:00

  • TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes.

    abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu112

    authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

    更新日期：2014-07-01 00:00:00

  • Physiological and pathophysiological roles of eicosanoids in the microcirculation.

    abstract：:Eicosanoids are important mediators of both physiological and pathophysiological responses of the microcirculation. These biologically active lipid mediators can be produced locally by the cellular elements within the microvasculature (endothelium, pericytes, smooth muscle cells) as well as interstitial cells (e.g. fi...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：

    authors： Gerritsen ME

    更新日期：1996-10-01 00:00:00

  • Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.

    abstract：OBJECTIVES:Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-)). METHODS:Nineteen adult annexin A7(-/-) and 14 wild-type m...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2007.07.001

    authors： Schrickel JW,Brixius K,Herr C,Clemen CS,Sasse P,Reetz K,Grohé C,Meyer R,Tiemann K,Schröder R,Bloch W,Nickenig G,Fleischmann BK,Noegel AA,Schwinger RH,Lewalter T

    更新日期：2007-11-01 00:00:00

  • Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia.

    abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2004.10.019

    authors： Pfosser A,Thalgott M,Büttner K,Brouet A,Feron O,Boekstegers P,Kupatt C

    更新日期：2005-02-15 00:00:00

  • Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.

    abstract：OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Hide EJ,Thiemermann C

    更新日期：1996-06-01 00:00:00

  • Possibilities, limitations, and technique for the study of regional myocardial perfusion in man by Xenon-133.

    abstract：:The theoretical possibilities and the practical limitations of the Xenon-133 (133Xe) method for the study of regional myocardial perfusion in man are discussed. The techniques for data acqusition and processing developed over the past 5 years are described in detail. Illustrative examples of experimental findings are ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/11.4.277

    authors： Maseri A,L'abbate A,Michelassi C,Pesola A,Pisani P,Marzilli M,De Nes M,Mancini P

    更新日期：1977-07-01 00:00:00

  • Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P).

    abstract：:Numerous epidemiological studies documented an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease. However, clinical interventions targeting HDL cholesterol failed to show clinical benefits with respect to cardiovascular risk reduction, sugge...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvu136

    authors： Potì F,Simoni M,Nofer JR

    更新日期：2014-08-01 00:00:00

  • A gene therapeutic approach to inhibit calcium and integrin binding protein 1 ameliorates maladaptive remodelling in pressure overload.

    abstract：Aims:Chronic heart failure is becoming increasingly prevalent and is still associated with a high mortality rate. Myocardial hypertrophy and fibrosis drive cardiac remodelling and heart failure, but they are not sufficiently inhibited by current treatment strategies. Furthermore, despite increasing knowledge on cardiom...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvy154

    authors： Grund A,Szaroszyk M,Döppner JK,Malek Mohammadi M,Kattih B,Korf-Klingebiel M,Gigina A,Scherr M,Kensah G,Jara-Avaca M,Gruh I,Martin U,Wollert KC,Gohla A,Katus HA,Müller OJ,Bauersachs J,Heineke J

    更新日期：2019-01-01 00:00:00

  • Left ventricular length dependent activation in the isovolumetric rat heart.

    abstract：STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, pr...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/24.3.254

    authors： Stefanon I,Vassallo DV,Mill JG

    更新日期：1990-03-01 00:00:00

  • Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.

    abstract：AIMS:n-3 Polyunsaturated fatty acids (PUFAs) are known to protect the cardiovascular system and improve blood pressure control. These important dietary constituents are converted into bioactive metabolites, but their role in regulation of the cardiovascular system is unclear. In particular, the functions of the cytochr...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvq411

    authors： Wang RX,Chai Q,Lu T,Lee HC

    更新日期：2011-05-01 00:00:00

  • Cardiomyopathies in disorders of oxidative metabolism.

    abstract：:Primary cardiomyopathy is an important cause of mortality in children and adults. Apart from inherited disorders of myocardial contractile and structural proteins, several defects of energy metabolism may cause cardiomyopathy. Most of the energy required for myocardial contraction is derived from aerobic metabolism. F...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(97)00141-7

    authors： Antozzi C,Zeviani M

    更新日期：1997-08-01 00:00:00