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Changes in regional coronary blood flow with hypertonic mannitol in conscious dogs.

Abstract：

:Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals compared to 80% in the awake ones. In both groups mannitol exerted a significant positive inotropic effect as evidenced by increases in maximal LV dp/dt and dp/dt/p. These studies have also demonstrated that the intact conscious dog that has not received any sedation has an inner:outer wall left ventricular flow ratio greater than 1-0.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

doi

10.1093/cvr/9.1.47

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

47-55

issue

1

eissn

0008-6363

issn

1755-3245

journal_volume

9

pub_type

杂志文章

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