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Adaptive mechanisms of the aorta and left ventricle to volume overloading following abrupt aortic regurgitation in rabbits.

Abstract：

STUDY OBJECTIVE:Compensatory mechanisms of the left ventricle for volume overloading caused by acute aortic regurgitation and associated changes in physiological properties of the aorta were studied in rabbits. DESIGN:Aortic regurgitation was produced by aortic valve perforation, and haemodynamic measurements were performed before, 1 h and 4 weeks afterwards. Characteristic impedance of the distensibility of the aorta were calculated. EXPERIMENTAL ANIMALS:42 Japanese white rabbits were used. The animals were anaesthetised with intravenous urethane. MEASUREMENTS AND MAIN RESULTS:Total systemic vascular resistance did not change significantly during the 4 weeks. When aortic regurgitation was produced, an immediate increase in circumferential distensibility was followed by the gradual dilatation of the aorta. An increase in circumferential distensibility resulted in decreased characteristic impedance, and the reduction in cardiac output caused by aortic regurgitation was compensated by increased systolic shortening of left ventricular dimensions at 1 h. After 4 weeks, however, decreased characteristic impedance was associated with increased aortic diameters during both systole and diastole, and dilatation and hypertrophy of the left ventricle were responsible for compensation of left ventricular performance. CONCLUSIONS:Volume overloading of the left ventricle by aortic regurgitation gave rise to a two stage compensatory process over a 4 week period and the aorta interacted with chronological changes in left ventricular performance.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Wainai Y

doi

10.1093/cvr/25.6.463

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

463-7

issue

6

eissn

0008-6363

issn

1755-3245

journal_volume

25

pub_type

杂志文章

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