Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Myogenic tone, which has a major role in the regulation of local blood flow, refers to the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure. Although Rho-kinase is involved in myogenic tone, the pathway involved remains unclear, especially concerning translocation...

journal_title：Cardiovascular research

authors： Dubroca C,Loyer X,Retailleau K,Loirand G,Pacaud P,Feron O,Balligand JL,Lévy BI,Heymes C,Henrion D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The mechanism of defibrillation is controversial. Reentry appearing immediately after the shock has been shown to be responsible for defibrillation failure in some studies while other studies have demonstrated that a rapid train of focal activations with the first focus appearing >50 ms after the shock is re...

journal_title：Cardiovascular research

authors： Chattipakorn N,Banville I,Gray RA,Ideker RE

更新日期：2004-01-01 00:00:00

abstract：Aims:Currently, efficient regimens to reverse atherosclerotic plaques are not available in the clinic. Herein, we present sonodynamic therapy (SDT) as a novel methodology to rapidly inhibit progression of atherosclerotic plaques. Methods and results:In atherosclerotic rabbit and apoE-deficient mouse models, SDT effici...

journal_title：Cardiovascular research

authors： Sun X,Guo S,Yao J,Wang H,Peng C,Li B,Wang Y,Jiang Y,Wang T,Yang Y,Cheng J,Wang W,Cao Z,Zhao X,Li X,Sun J,Yang J,Tian F,Chen X,Li Q,Gao W,Shen J,Zhou Q,Wang P,Li Z,Tian Z,Zhang Z,Cao W,Li M,Tian Y

更新日期：2019-01-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the effects of long-term treatment with an alpha 1 blocker, bunazosin hydrochloride, on blood pressure, heart weight, myocardial contractility, and ventricular myosin isoenzyme pattern in spontaneously hypertensive rats (SHR). DESIGN:Bunazosin hydrochloride was given orally i...

journal_title：Cardiovascular research

authors： Takeda N,Nakamura I,Ohkubo T,Iwai T,Tanamura A,Nagano M

更新日期：1991-07-01 00:00:00

abstract：:Rupture of vulnerable atherosclerotic plaques leading to an atherothrombotic event is the primary driver of myocardial infarction and stroke. The ability to detect non-invasively the presence and evolution of vulnerable plaques could have a huge impact on the future identification and management of atherosclerotic car...

journal_title：Cardiovascular research

authors： MacAskill MG,Newby DE,Tavares AAS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the influence of coronary occlusion on myocardial interstitial noradrenaline levels in the ischaemic and non-ischaemic regions, using the dialysis technique. METHODS:In nine anaesthetised cats, regional ischaemia was produced by occlusion of the left anterior descending coronary ar...

journal_title：Cardiovascular research

authors： Akiyama T,Yamazaki T,Ninomiya I

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:The present work is aimed at elucidating the signalling pathway(s) triggered by activation of A(2A) receptors involved in the facilitation of noradrenaline release in rat tail artery as an attempt to clarify their role in the cardiovascular system. METHODS:Electrically evoked (5 Hz, 100 pulses, 1 ms) tritium...

journal_title：Cardiovascular research

authors： Fresco P,Diniz C,Gonçalves J

更新日期：2004-09-01 00:00:00

abstract：AIMS:The discovery of a specific prorenin receptor (PRR) suggests a biological function of prorenin that is independent of angiotensin I production. In the present study, we investigated the role of PRR on smooth muscle cell (SMC) migration. METHODS AND RESULTS:PRR was expressed in human mammary arteries and in cultur...

journal_title：Cardiovascular research

authors： Greco CM,Camera M,Facchinetti L,Brambilla M,Pellegrino S,Gelmi ML,Tremoli E,Corsini A,Ferri N

更新日期：2012-08-01 00:00:00

abstract：:Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate clearly have robust NO-like effects in humans, including blood pressure reduction, inhibition of platelet aggregation, and vasoprot...

journal_title：Cardiovascular research

authors： Lundberg JO,Carlström M,Larsen FJ,Weitzberg E

更新日期：2011-02-15 00:00:00

abstract：:Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

journal_title：Cardiovascular research

authors： Zhu H,Fan GC

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...

journal_title：Cardiovascular research

authors： Dai-Do D,Espinosa E,Liu G,Rabelink TJ,Julmy F,Yang Z,Mahler F,Lüscher TF

更新日期：1996-11-01 00:00:00

abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

journal_title：Cardiovascular research

authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

更新日期：2015-06-01 00:00:00

abstract：AIMS:Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma isoforms and their downstream effector pathways in mediating endothe...

journal_title：Cardiovascular research

authors： Heller R,Chang Q,Ehrlich G,Hsieh SN,Schoenwaelder SM,Kuhlencordt PJ,Preissner KT,Hirsch E,Wetzker R

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether infusion of either atrial natriuretic factor (ANF, 800 ng.h-1.rat-1) or a specific inhibitory of neutral endopeptidase 24.11 (NEI, UK 73,967, 5.4 mg.kg-1.d-1) can influence the reversal of the pulmonary vascular remodelling produced by exposure to hypoxia. METHODS:Male Wist...

journal_title：Cardiovascular research

authors： Zhao L,Hughes JM,Winter RJ

更新日期：1994-04-01 00:00:00

abstract：AIMS:Smad7 plays a negative regulatory role in many inflammatory diseases, but its effect on hypertensive disease remains unknown. The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II)-mediated hypertensive cardiac remodelling. METHODS AND RESUL...

journal_title：Cardiovascular research

authors： Wei LH,Huang XR,Zhang Y,Li YQ,Chen HY,Yan BP,Yu CM,Lan HY

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) attenuates neutrophil (PMN)-mediated damage, partly by inhibiting superoxide anion (O2-) generation and adherence to the coronary artery endothelium. L-Arginine is the endogenous substrate for production of NO via the NO synthase pathway. This study tested the hypothesis that the endogenous...

journal_title：Cardiovascular research

authors： Sato H,Zhao ZQ,Vinten-Johansen J

更新日期：1996-01-01 00:00:00

abstract：AIMS:The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in the heart; (ii...

journal_title：Cardiovascular research

authors： Hölscher M,Schäfer K,Krull S,Farhat K,Hesse A,Silter M,Lin Y,Pichler BJ,Thistlethwaite P,El-Armouche A,Maier LS,Katschinski DM,Zieseniss A

更新日期：2012-04-01 00:00:00

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00

abstract：:Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent st...

journal_title：Cardiovascular research

authors： Sharma N,Okere IC,Duda MK,Chess DJ,O'Shea KM,Stanley WC

更新日期：2007-01-15 00:00:00

abstract：OBJECTIVE:Inducible costimulator (ICOS) is a member of the CD28 family. Although inflammation is an essential pathological feature of myocarditis, the role of ICOS in myocarditis remains unclear. METHODS AND RESULTS:Lewis rats were immunized on day 0 with purified porcine cardiac myosin to establish experimental autoi...

journal_title：Cardiovascular research

authors： Futamatsu H,Suzuki J,Kosuge H,Yokoseki O,Kamada M,Ito H,Inobe M,Isobe M,Uede T

更新日期：2003-07-01 00:00:00

abstract：AIMS:Insulin (Ins) resistance (IRES) associates to increased cardiovascular risk as observed in metabolic syndrome. Chronic stimulation of beta-adrenergic receptors (betaAR) due to exaggerated sympathetic nervous system activity is involved in the pathogenesis of IRES. The cellular levels of G protein coupled receptor ...

journal_title：Cardiovascular research

authors： Cipolletta E,Campanile A,Santulli G,Sanzari E,Leosco D,Campiglia P,Trimarco B,Iaccarino G

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF), which plays a pivotal role in the control of inflammatory responses, was first characterized as a T-cell cytokine, but later was also found as a pituitary peptide released in response to infection and stress. However, MIF's role and expression in the myocardium ha...

journal_title：Cardiovascular research

authors： Takahashi M,Nishihira J,Shimpo M,Mizue Y,Ueno S,Mano H,Kobayashi E,Ikeda U,Shimada K

更新日期：2001-12-01 00:00:00

abstract：:Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart failure. Multiple structural and biochemical reasons have been suggested to induce this disorder. The most prominent feature of the diabetic myocardium is attenuated insulin signalling that reduces survival kinases (Akt), potentiall...

journal_title：Cardiovascular research

authors： Puthanveetil P,Wan A,Rodrigues B

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate in a minipig model of acute myocardial infarction the cardioprotection provided by the beta adrenoceptor blocking and vasodilating activities present in carvedilol; comparison was made to the pure beta adrenoceptor antagonist, propranolol. METHODS:Experiments were performed in 25 Yuca...

journal_title：Cardiovascular research

authors： Bril A,Slivjak M,DiMartino MJ,Feuerstein GZ,Linee P,Poyser RH,Ruffolo RR Jr,Smith EF 3rd

更新日期：1992-05-01 00:00:00

abstract：:The effects of both gradual and abrupt coronary occlusion on regional wall function (sonomicrometry) and left ventricular relaxation were studied in the intact dog heart. The ischaemic dysfunction observed in the two interventions as assessed by pressure-length loops showed considerably different patterns. The regiona...

journal_title：Cardiovascular research

authors： Doyle RL,Foëx P,Ryder WA,Jones LA

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situati...

journal_title：Cardiovascular research

authors： Hale SL,Kloner RA

更新日期：1998-12-01 00:00:00

abstract：:The theory related to the loss of R waves and appearance of Q waves in acute myocardial infarction is discussed. A method of praecordial mapping of RS ratio changes and the appearance of Q waves that occur in acute myocardial infarction is described. The serial changes in these electrocardiographic signs in 17 patient...

journal_title：Cardiovascular research

authors： Selwyn AP,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：:The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wa...

journal_title：Cardiovascular research

authors： Westerhof BE,Saouti N,van der Laarse WJ,Westerhof N,Vonk Noordegraaf A

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). METHODS:Dogs were paced for 3 weeks at 240 BPM to induce heart failure which was confirmed with hemodynamic and echocardiographic measurements. The pacemaker was turned off 30 min prior to the ischemia study. Normal...

journal_title：Cardiovascular research

authors： Hoskins DE,Ignasiak DP,Saganek LJ,Gallagher KP,Peterson JT

更新日期：1996-08-01 00:00:00