Abstract:
STUDY OBJECTIVE:The aim was to determine whether taurine influences the membrane surface charges in cardiac muscle. DESIGN:Screening of the negative charges at the outside surface of the membrane results in a shift of the steady state inactivation of the sodium system towards less negative potentials. This feature was used to study eventual effects of taurine on surface charges and the data were compared to the known influence of varying extracellular calcium. EXPERIMENTAL MATERIAL:New Zealand rabbits (6-7 weeks, 1.25-1.75 kg) were anesthetised and the hearts were rapidly excised and perfused with the Langendorff technique. MEASUREMENTS AND MAIN RESULTS:Standard microelectrodes were used to determine the effects of 20 mM taurine and varying Ca concentrations (from 0.3 to 5.0 mM) on action potential parameters. The resting potential was varied by changing extracellular K between 2.5 and 10 mM. Taurine significantly depolarised the membrane by about 3 mV between 5 and 10 mM Ko but not at 2.5 mM; the maximum rate of depolarisation (dV/dTmax) decreased significantly at all Ko except at 10 mM where taurine caused arrhythmias or cardiac arrest. The dV/dTmax upsilon resting potential relationship (a measure for the steady state sodium current inactivation) was not changed by taurine, but the current was depressed as a function of membrane potential, the depression being more pronounced at more positive membrane potentials. An increase in Cao from 0.3 to 5.0 mM displaced the half maximal value of the dV/dtmax upsilon resting potential relationship from -79 to -67 mV, showing that the screening effect of Ca on the negative charges at the outside surface of the membrane could be detected with this experimental approach. CONCLUSIONS:The decrease of the fast Na current by taurine can explain the arrhythmias observed at 10 mM external potassium, whereas the surface charges of the glycocalix were not affected.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Dumaine R,Schanne OF,Ruiz-Petrich Edoi
10.1093/cvr/24.11.918subject
Has Abstractpub_date
1990-11-01 00:00:00pages
918-24issue
11eissn
0008-6363issn
1755-3245journal_volume
24pub_type
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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更新日期:2005-07-01 00:00:00
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更新日期:1994-05-01 00:00:00
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更新日期:2000-07-01 00:00:00
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doi:10.1093/cvr/24.12.1013
更新日期:1990-12-01 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/0008-6363(96)00131-9
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更新日期:1996-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/14.5.288
更新日期:1980-05-01 00:00:00
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doi:10.1093/cvr/cvp273
更新日期:2010-01-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:1991-09-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvs014
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1093/cvr/cvy227
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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更新日期:1987-04-01 00:00:00
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更新日期:2015-09-01 00:00:00
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doi:10.1016/j.cardiores.2005.11.021
更新日期:2006-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/16.11.637
更新日期:1982-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1016/j.cardiores.2004.11.020
更新日期:2005-02-15 00:00:00
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doi:10.1093/cvr/20.2.81
更新日期:1986-02-01 00:00:00
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更新日期:2000-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/20.10.721
更新日期:1986-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00539-4
更新日期:2002-11-01 00:00:00