An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in the hypertensive rat.

abstract：:Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and...

journal_title：Cardiovascular research

authors： Ware JS,Petretto E,Cook SA

更新日期：2013-03-15 00:00:00

abstract：:Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of c...

journal_title：Cardiovascular research

authors： Carey RA,Tipton CM,Lund DR

更新日期：1976-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, pr...

journal_title：Cardiovascular research

authors： Stefanon I,Vassallo DV,Mill JG

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE AND METHODS:We have previously demonstrated that mechanical loading of cardiac fibroblasts leads to increased synthesis and gene expression of the extracellular matrix protein collagen. We hypothesised that the upregulation of procollagen gene expression in cardiac fibroblasts, in response to cyclic mechanica...

journal_title：Cardiovascular research

authors： Papakrivopoulou J,Lindahl GE,Bishop JE,Laurent GJ

更新日期：2004-03-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) is a devastating condition for which no disease-modifying therapies exist. PH is recognized as proliferative disease of the pulmonary artery (PA). In the experimental newborn calf model of hypoxia-induced PH, adventitial fibroblasts in the PA wall exhibit a heightened replication index....

journal_title：Cardiovascular research

authors： Panzhinskiy E,Zawada WM,Stenmark KR,Das M

更新日期：2012-08-01 00:00:00

abstract：:Hydrogen sulfide (H2S), as a gaseous signalling molecule, has been found to play important roles in postconditioning (PostC)-induced cardioprotection. Similar to nitric oxide (NO)-mediated protein S-nitrosylation (SNO), recent studies suggest that H2S could regulate protein function through another redox-based post-tr...

journal_title：Cardiovascular research

authors： Sun J,Aponte AM,Menazza S,Gucek M,Steenbergen C,Murphy E

更新日期：2016-05-01 00:00:00

abstract：:The structural nature of fibrillar collagen involved in the replacement fibrosis which accompanies discrete areas of cell necrosis remains uncertain, as does its influence on the diastolic and systolic stiffness of the intact myocardium. This study, using 15 micron diameter microsphere embolisation of the rat myocardi...

journal_title：Cardiovascular research

authors： Carroll EP,Janicki JS,Pick R,Weber KT

更新日期：1989-08-01 00:00:00

abstract：:Muscle tissue in atrioventricular (A-V) cardiac valve leaflets was studied in 35 human hearts and was found to be more prominent in the anterior leaflet of the mitral (MAL) than in the other valve leaflets. From serial sectioning and wax model reconstruction, the anatomic arrangement of the muscle in the MAL indicates...

journal_title：Cardiovascular research

authors： Boucek RJ,Boucková B,Levy S

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVES:I(Ks), the slow component of the delayed rectifier potassium current, underlies a strong beta-adrenergic regulation in the heart. Catecholamines, like isoproterenol, induce a strong increase in I(Ks). Recent work has pointed to an opposing biological effect of beta(1)- and beta(3)-adrenoceptors in the heart....

journal_title：Cardiovascular research

authors： Bosch RF,Schneck AC,Kiehn J,Zhang W,Hambrock A,Eigenberger BW,Rüb N,Gogel J,Mewis C,Seipel L,Kühlkamp V

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVES:Age-related medial calcification (elastocalcinosis) of large arteries is accelerated in diabetes and appears mainly in distal arteries. The aim was to devise a rat model of elastocalcinosis in association with diabetes to examine the hypothesis that diabetes accelerates vascular calcification experimentally....

journal_title：Cardiovascular research

authors： Bouvet C,Peeters W,Moreau S,DeBlois D,Moreau P

更新日期：2007-02-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：:Platelet-dependent thrombus formation is a key event in the pathogenesis of acute myocardial infarction (AMI). Platelets mediate both thrombotic occlusion of the entire epicardial coronary artery and also accumulate in the microcirculation resulting in impairment of microcirculation and provoking myocardial ischemia d...

journal_title：Cardiovascular research

authors： Gawaz M

更新日期：2004-02-15 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare platelet function in diabetic and non-diabetic survivors of acute myocardial infarction and to relate it to an index of free radical activity in these patients. DESIGN:In vivo and in vitro indices of platelet function and diene conjugate molar ratios were measured in diabetic and...

journal_title：Cardiovascular research

authors： Hendra TJ,Wickens DG,Dormandy TL,Yudkin JS

更新日期：1991-08-01 00:00:00

abstract：AIMS:The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and concentric hypertrop...

journal_title：Cardiovascular research

authors： Dodd MS,Ball DR,Schroeder MA,Le Page LM,Atherton HJ,Heather LC,Seymour AM,Ashrafian H,Watkins H,Clarke K,Tyler DJ

更新日期：2012-07-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers responsible for AF, as well as the fundamental mechanisms governing th...

journal_title：Cardiovascular research

authors： Alvarez-Franco A,Rouco R,Ramirez RJ,Guerrero-Serna G,Tiana M,Cogliati S,Kaur K,Saeed M,Magni R,Enriquez JA,Sanchez-Cabo F,Jalife J,Manzanares M

更新日期：2020-10-29 00:00:00

abstract：OBJECTIVE:The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. METHODS:Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph at 75 mmHg. Under this condition, segments spontaneously constricted from a passive dia...

journal_title：Cardiovascular research

authors： Bakker EN,Kerkhof CJ,Sipkema P

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Oxidized low-density lipoproteins (ox-LDL) or their components suppress macrophage inflammatory response by down-regulating cytokine synthesis, nitric oxide synthase and inducible cyclooxygenase (Cox-2). This event is crucial for the pathophysiological process leading to the formation of atherosclerotic plaqu...

journal_title：Cardiovascular research

authors： Eligini S,Brambilla M,Banfi C,Camera M,Sironi L,Barbieri SS,Auwerx J,Tremoli E,Colli S

更新日期：2002-08-01 00:00:00

abstract：AIMS:This study examines the effect of endogenous male sex hormones on thromboxane A2 (TXA2), prostaglandin (PG) I2, PGF(2 alpha), and PGE I2 release, as well as their role in acetylcholine (ACh)-mediated relaxation in the aorta. METHODS AND RESULTS:Aortic segments from orchidectomized and control male Sprague-Dawley ...

journal_title：Cardiovascular research

authors： Martorell A,Blanco-Rivero J,Aras-López R,Sagredo A,Balfagón G,Ferrer M

更新日期：2008-02-01 00:00:00

abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

journal_title：Cardiovascular research

authors： Vaughn Williams EM,Millar JS,Campbell TJ

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：:Mayer waves are oscillations of arterial pressure occurring spontaneously in conscious subjects at a frequency lower than respiration (approximately 0.1 Hz in humans). Mayer waves are tightly coupled with synchronous oscillations of efferent sympathetic nervous activity and are almost invariably enhanced during states...

journal_title：Cardiovascular research

authors： Julien C

更新日期：2006-04-01 00:00:00

abstract：AIMS:Exercise started early after myocardial infarction (MI) improves in vivo cardiac function and myofilament responsiveness to Ca(2+). We investigated whether this represents partial or complete reversal of cellular remodelling. METHODS AND RESULTS:Mice with MI following left coronary ligation were given free access...

journal_title：Cardiovascular research

authors： Bito V,de Waard MC,Biesmans L,Lenaerts I,Ozdemir S,van Deel E,Abdel-Mottaleb Y,Driesen R,Holemans P,Duncker DJ,Sipido KR

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator in ischemic heart disease. The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS:Epicardial coronary arteries obtained from pat...

journal_title：Cardiovascular research

authors： Dahm PL,Bodelsson M,Törnebrandt K,Muddle JR,Sykes RM,Yacoub M,Dashwood MR

更新日期：1996-05-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：STUDY OBJECTIVE:Compensatory mechanisms of the left ventricle for volume overloading caused by acute aortic regurgitation and associated changes in physiological properties of the aorta were studied in rabbits. DESIGN:Aortic regurgitation was produced by aortic valve perforation, and haemodynamic measurements were per...

journal_title：Cardiovascular research

authors： Wainai Y

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:Adenosine inhibits neutrophil adhesion and injury to isolated cardiac myocytes. In the present study, the contribution of selectin and CD18 interactions to neutrophil-myocyte adhesion and their sensitivity to adenosine were assessed. METHODS:Activated human neutrophils and canine myocytes were incubated with...

journal_title：Cardiovascular research

authors： Bullough DA,Magill MJ,Mullane KM,Firestein GS

更新日期：1996-08-01 00:00:00

abstract：:The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action potentials were studied for nine Class I anti-arrhythmic drugs using standard microelectrode techniques. The drugs were found to fall into three well-demarcated subgroups with "fast" (lignocaine...

journal_title：Cardiovascular research

authors： Campbell TJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:Research in the pathophysiology of ischemia/reperfusion or redox signaling is hindered by lack of simple methodology to measure short-lived oxygen radicals. In the presence of hydroxyl radical ((*)OH), d-phenylalanine (d-Phe) yields para-, meta- and ortho-tyrosine. We have previously demonstrated that d-Phe c...

journal_title：Cardiovascular research

authors： Biondi R,Ambrosio G,Liebgott T,Cardounel AJ,Bettini M,Tritto I,Zweier JL

更新日期：2006-07-15 00:00:00

abstract：AIMS:The risk of mortality from the coronavirus disease that emerged in 2019 (COVID-19) is increased by comorbidity from cardiovascular and pulmonary diseases. Air pollution also causes excess mortality from these conditions. Analysis of the first severe acute respiratory syndrome coronavirus (SARS-CoV-1) outcomes in 2...

journal_title：Cardiovascular research

authors： Pozzer A,Dominici F,Haines A,Witt C,Münzel T,Lelieveld J

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. METHODS:In situ hybridizations with Cx40 and ...

journal_title：Cardiovascular research

authors： Van Kempen MJ,Vermeulen JL,Moorman AF,Gros D,Paul DL,Lamers WH

更新日期：1996-11-01 00:00:00