Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.

abstract：OBJECTIVE:Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death in heart failure but it must be demonstrated by multiple criteria and not just TUNEL staining alone. Previously, we and others have demonstrated that be...

journal_title：Cardiovascular research

authors： Knaapen MW,Davies MJ,De Bie M,Haven AJ,Martinet W,Kockx MM

更新日期：2001-08-01 00:00:00

abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...

journal_title：Cardiovascular research

authors： Teng B,Smith JD,Rosenfeld ME,Robinet P,Davis ME,Morrison RR,Mustafa SJ

更新日期：2014-04-01 00:00:00

abstract：:Mouse models have been frequently used in the study of Chlamydia pneumoniae (also known as Chlamydophila pneumoniae) infections. This gram-negative obligate intracellular bacterium causes respiratory infections, followed by dissemination of the bacterium to various organs throughout the body, including cardiovascular ...

journal_title：Cardiovascular research

authors： de Kruif MD,van Gorp EC,Keller TT,Ossewaarde JM,ten Cate H

更新日期：2005-02-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether depressed myocardial contractility is responsible for the decline in stroke volume that occurs with cardiac tamponade. DESIGN:Left ventricular contractile performance was assessed before and after beta adrenergic blockade using the end systolic pressure-volume relation,...

journal_title：Cardiovascular research

authors： Johnston WE,Vinten-Johansen J,Klopfenstein HS,Santamore WP,Little WC

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...

journal_title：Cardiovascular research

authors： Philipp S,Yang XM,Cui L,Davis AM,Downey JM,Cohen MV

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:It has been proposed that human immunodeficiency virus (HIV) infection-induced inflammatory environment may contribute to the pathogenesis of cardiovascular diseases. Recent studies have also demonstrated the potential role of estrogen as therapeutic agents in the prevention or treatment of cardiovascular dis...

journal_title：Cardiovascular research

authors： Lee YW,Eum SY,Nath A,Toborek M

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertr...

journal_title：Cardiovascular research

authors： Ha T,Li Y,Hua F,Ma J,Gao X,Kelley J,Zhao A,Haddad GE,Williams DL,William Browder I,Kao RL,Li C

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:Prior studies have shown that the performance of the left ventricle on any one beat is influenced by the mechanical events of the previous beat, a phenomenon called "previous-beat contraction history". This previous-beat contraction history, which appears to be an interplay between the mechanical events of o...

journal_title：Cardiovascular research

authors： Slinker BK,Tobias AH

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the ventricular/vascular coupling of the intact right heart under conditions of normal operation and acute pulmonary hypertension. METHODS:Right ventricular contractility was obtained by calculating the end systolic pressure-volume relationship (Ees) and the effective pulmonary art...

journal_title：Cardiovascular research

authors： Fourie PR,Coetzee AR,Bolliger CT

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVES:Myostatin, a member of the transforming growth factor-beta (TGF-beta) family, plays a key role in skeletal muscle myogenesis by limiting hyperplastic and hypertrophic muscle growth. In cardiac muscle, myostatin has been shown to limit agonist-induced cardiac hypertrophic growth. However, its role in cardiac ...

journal_title：Cardiovascular research

authors： McKoy G,Bicknell KA,Patel K,Brooks G

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:We determine if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. METHODS:We determined the effect of the weakly vasodilating KATP opener, BMS-180448...

journal_title：Cardiovascular research

authors： Grover GJ,D'Alonzo AJ,Hess T,Sleph PG,Darbenzio RB

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

journal_title：Cardiovascular research

authors： Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

更新日期：2006-09-01 00:00:00

abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

journal_title：Cardiovascular research

authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

更新日期：2015-06-01 00:00:00

abstract：AIMS:The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration, proliferation, and capillary-like tube formation in vitro. It is unknown whether S1P stimulates in vivo angiogenesis induced under tissue ischaemia. We investigated the effects of both exogenously...

journal_title：Cardiovascular research

authors： Oyama O,Sugimoto N,Qi X,Takuwa N,Mizugishi K,Koizumi J,Takuwa Y

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:This study investigated whether endothelial dysfunction occurs in mesenteric arteries of apoE-deficient mice and determined the role of endothelin (ET)-1, which is increased in human atherosclerosis, using an orally active endothelin ET(A) receptor antagonist. METHODS:ApoE-deficient and C57BL/6J control mice...

journal_title：Cardiovascular research

authors： d'Uscio LV,Barton M,Shaw S,Lüscher TF

更新日期：2002-02-01 00:00:00

abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

journal_title：Cardiovascular research

authors： Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

更新日期：2021-01-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecular mechanism for and the phosphorylation sites for the enhanced MLC pho...

journal_title：Cardiovascular research

authors： Shimokawa H,Seto M,Katsumata N,Amano M,Kozai T,Yamawaki T,Kuwata K,Kandabashi T,Egashira K,Ikegaki I,Asano T,Kaibuchi K,Takeshita A

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The aim was to compare differences in peak twitch force occurring despite similar degrees of right ventricular hypertrophy in ferrets with pulmonary artery banding at either weanling or juvenile age. METHODS:After inducing pressure overload hypertrophy by banding the pulmonary artery of weanling and juvenile...

journal_title：Cardiovascular research

authors： Gwathmey JK,Liao R,Ingwall JS

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:The highly selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyl-adenosine (CCPA), has been shown to be as cardioprotective as ischaemic preconditioning when evaluated with an early staining method using tetrazolium. However, tetrazolium-positive tissue measured 3 h after reperfusion may still over...

journal_title：Cardiovascular research

authors： Tsuchida A,Liu GS,Wilborn WH,Downey JM

更新日期：1993-04-01 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：:Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

journal_title：Cardiovascular research

authors： Zhu H,Fan GC

更新日期：2012-05-01 00:00:00

abstract：AIMS:JNJ-64179375 (hereafter JNJ-9375) is a first-in-class, highly specific, large molecule, exosite 1 thrombin inhibitor. In preclinical studies, JNJ-9375 demonstrated robust antithrombotic protection with a wider therapeutic index when compared to apixaban. The purpose of the present study was to examine for the firs...

journal_title：Cardiovascular research

authors： Wilson SJ,Connolly TM,Peters G,Ghosh A,Johnson M,Newby DE

更新日期：2019-03-01 00:00:00

abstract：AIMS:Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS:Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naï...

journal_title：Cardiovascular research

authors： MacRitchie N,Grassia G,Noonan J,Cole JE,Hughes CE,Schroeder J,Benson RA,Cochain C,Zernecke A,Guzik TJ,Garside P,Monaco C,Maffia P

更新日期：2020-02-01 00:00:00

abstract：:The renin-angiotensin-aldosterone (RAA) system and the endothelin (ET) system entail the most potent vasopressor mechanisms identified to date. Although they were studied in depth in relation to arterial hypertension and cardiovascular diseases, limited information on their interrelationships in causing hypertension a...

journal_title：Cardiovascular research

authors： Rossi GP,Sacchetto A,Cesari M,Pessina AC

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the changes in beta-adrenoceptor density (Bmax) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopa...

journal_title：Cardiovascular research

authors： van Veldhuisen DJ,Brodde OE,van Gilst WH,Schulze C,Hegeman H,Anthonio RL,Scholtens E,de Graeff PA,Wesseling H,Lie KI

更新日期：1995-09-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to enhanced free radical production that in turn causes DNA strand breakage culminating in poly(ADP-ribose) polymerase (PARP) activation and mitochondrial and cellular d...

journal_title：Cardiovascular research

authors： Szántó M,Rutkai I,Hegedus C,Czikora Á,Rózsahegyi M,Kiss B,Virág L,Gergely P,Tóth A,Bai P

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：ABSTRACT:Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an overwhelming host response to infection resulting in organ failure. The endothelium is an active contributor to sepsis and as such represents a major target for therapy. During sepsis, endothelial cells amplify the immune response...

journal_title：Cardiovascular research

authors： Dolmatova EV,Wang K,Mandavilli R,Griendling KK

更新日期：2021-01-01 00:00:00