Effects of intracellular sodium and hydrogen ion on the sodium activated potassium channel in isolated patches from guinea pig ventricular myocytes.

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Jervell and Lange-Nielsen syndrome (JLNS) is a recessively inherited long QT syndrome (LQTS) characterised by profound sensorineural deafness and predisposition to syncope and sudden cardiac death. Mutation analysis has established the presence of mutations in affected individuals in the genes KCNQ1 and KCNE1...

journal_title：Cardiovascular research

authors： Huang L,Bitner-Glindzicz M,Tranebjaerg L,Tinker A

更新日期：2001-09-01 00:00:00

abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

journal_title：Cardiovascular research

authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

更新日期：2016-10-01 00:00:00

abstract：AIMS:The molecular mechanisms controlling heart function and rhythmicity are incompletely understood. While it is widely accepted that the type 2 ryanodine receptor (Ryr2) is the major Ca(2+) release channel in excitation-contraction coupling, the role of these channels in setting a consistent beating rate remains cont...

journal_title：Cardiovascular research

authors： Bround MJ,Asghari P,Wambolt RB,Bohunek L,Smits C,Philit M,Kieffer TJ,Lakatta EG,Boheler KR,Moore ED,Allard MF,Johnson JD

更新日期：2012-12-01 00:00:00

abstract：:The heart responds to ischaemic stimuli with release of negative inotropic mediators such as cytokines, platelet-activating factor, oxygen free radicals, arachidonic acids, nitric oxide, adenosine, and still unidentified "cardiodepressant factors" that modulate myocardial performance via autocrine and paracrine coupli...

journal_title：Cardiovascular research

authors： Stangl V,Baumann G,Stangl K,Felix SB

更新日期：2002-01-01 00:00:00

abstract：:Isolated, buffer perfused guinea pig hearts were used to study the effects of sotalol on arrhythmias and electrophysiology during 30 min of myocardial ischaemia, induced by reducing coronary flow to 10% of control, and subsequent reperfusion. Action potentials were recorded using the floating microelectrode technique ...

journal_title：Cardiovascular research

authors： Culling W,Penny WJ,Sheridan DJ

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS:Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemi...

journal_title：Cardiovascular research

authors： Garcia-Dorado D,González MA,Barrabés JA,Ruiz-Meana M,Solares J,Lidon RM,Blanco J,Puigfel Y,Piper HM,Soler-Soler J

更新日期：1997-07-01 00:00:00

abstract：AIMS:We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test th...

journal_title：Cardiovascular research

authors： Broegger T,Jacobsen JC,Secher Dam V,Boedtkjer DM,Kold-Petersen H,Pedersen FS,Aalkjaer C,Matchkov VV

更新日期：2011-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to fibrosis. DESIGN:In 72 male Wistar rats (250-350 g) the transient stimul...

journal_title：Cardiovascular research

authors： Silver MA,Pick R,Brilla CG,Jalil JE,Janicki JS,Weber KT

更新日期：1990-09-01 00:00:00

abstract：:Impairment of contractile function and extent of release of several intracellular marker enzymes and DNA were studied in isolated perfused rat hearts after low-flow (0.16 ml . min-1) ischaemia followed by 2 h of reperfusion and after anoxia followed by 2 h of reoxygenation. After varying periods of ischaemia or anoxia...

journal_title：Cardiovascular research

authors： van der Laarse A,Altona JC,Zoet AC,Oemrawsingh P,van Dijkman PR

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:Lipoprotein lipase (LPL) mediated hydrolysis of circulating triglyceride (TG)-rich lipoproteins provides the heart with fatty acids. The present study was designed to investigate the influence of circulating TG and their lipolysis in facilitating translocation of LPL from the underlying cardiomyocyte cell sur...

journal_title：Cardiovascular research

authors： Pulinilkunnil T,Qi D,Ghosh S,Cheung C,Yip P,Varghese J,Abrahani A,Brownsey R,Rodrigues B

更新日期：2003-09-01 00:00:00

abstract：AIMS:ATP sensitive K(+) channels (K(ATP)) sense adenine nucleotide concentrations and thus couple the metabolic state of the cell to membrane potential. The hetero-octameric complex of a sulphonylurea receptor (SUR2B) and an inwardly rectifying K(+) channel (Kir6.1) and the corresponding native channel in smooth muscle...

journal_title：Cardiovascular research

authors： Farzaneh T,Tinker A

更新日期：2008-09-01 00:00:00

abstract：:An analytical formulation has been developed which allows the computation of mitral valve area (A) from the potentially noninvasive paramaeters of hear rate (R), cardiac output (CO) and diastolic filling period (DFP) by the equation A = 21 CO/R x DFP2. The computed areas correlate with autopsy and open heart measureme...

journal_title：Cardiovascular research

authors： Seitz WS,Operschall EJ

更新日期：1980-04-01 00:00:00

abstract：:Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

journal_title：Cardiovascular research

authors： Patel AP,Natarajan P

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...

journal_title：Cardiovascular research

authors： Vera N,Tse MY,Watson JD,Sarda S,Steinhelper ME,John SW,Flynn TG,Pang SC

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force-frequency relation which is reversed into a negative relation in preparation from failing hearts. Whether or not such relations between ventricular function and heart rate hold true in the i...

journal_title：Cardiovascular research

authors： Neumann T,Ravens U,Heusch G

更新日期：1998-02-01 00:00:00

abstract：AIMS:Extracellular nucleotides are vasoactive molecules. The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice. METHODS AND RESULTS:Immunofluore...

journal_title：Cardiovascular research

authors： Kauffenstein G,Drouin A,Thorin-Trescases N,Bachelard H,Robaye B,D'Orléans-Juste P,Marceau F,Thorin E,Sévigny J

更新日期：2010-01-01 00:00:00

abstract：:The heart is challenged by a plethora of extracellular stimuli over the course of a normal day, each of which distinctly influences myocardial contractile function. It is therefore not surprising that myocardial metabolism also oscillates in a time-of-day dependent manner. What is becoming increasingly apparent is tha...

journal_title：Cardiovascular research

authors： Bray MS,Young ME

更新日期：2008-07-15 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) cause extracellular matrix degradation and may be involved in the rupture of atherosclerotic plaques by degrading fibrous cap, resulting in the intravascular thrombus formation. Here we examined whether local overexpression of MMP-9 alters the characteristics of arteriosclerot...

journal_title：Cardiovascular research

authors： Morishige K,Shimokawa H,Matsumoto Y,Eto Y,Uwatoku T,Abe K,Sueishi K,Takeshita A

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Angiotensin II stimulates vascular smooth muscle cell (VSMC) growth, and is considered to be an important mediator of intimal thickening after vascular injury. Recent evidence has indicated that VSMC apoptosis plays a major role in the response to balloon injury, and we therefore examined the effect of angiot...

journal_title：Cardiovascular research

authors： Holm AM,Andersen CB,Haunsø S,Hansen PR

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H(2)O(2))-induced damage. METHODS:Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6 degrees grade, 5 days/week). Isolated perfused working hearts from ...

journal_title：Cardiovascular research

authors： Taylor RP,Ciccolo JT,Starnes JW

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Recent studies indicate that endothelial type nitric oxide synthase (NOS3) modulates cardiac systolic and diastolic function and the inotropic responsiveness to beta-adrenergic agonists, and may affect myocardial oxygen consumption. Although NOS3 is a constitutive protein, its levels of expression can be modi...

journal_title：Cardiovascular research

authors： Bayraktutan U,Yang ZK,Shah AM

更新日期：1998-06-01 00:00:00

abstract：:To define the interactions between blood and endocardium damaged by lactic acid, the left ventricles of 48 isolated continuously perfused and beating hearts were exposed for 0-4 hours to Krebs Henseleit buffer (KHB) with or without 33 mumol.ml-1 of lactic acid (pH 6.4). After excising its apex, the left ventricle was ...

journal_title：Cardiovascular research

authors： Carter G,Gavin JB

更新日期：1989-06-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：:The hypothesis that cardiac surgery to interrupt accessory pathways also interrupts autonomic nerves to the canine ventricle and to the atrioventricular node was tested in four groups of dogs. Group 1 (n = 6) underwent dissection of the atrioventricular fat tissue and cryolesion created by application of a cryoprobe a...

journal_title：Cardiovascular research

authors： Inoue H,Mahomed Y,Kovacs RJ,Zipes DP

更新日期：1988-03-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The presence is well established in unstable angina of intracoronary thrombosis in a stenosed epicardial coronary artery. The effects of the thrombus formation on the distal microcirculation are however still unclear. METHODS:We adapted the Folts canine model of left circumflex coronary arterial stenosis and...

journal_title：Cardiovascular research

authors： Mansaray M,Belcher PR,Vergroesen I,Wright ZM,Hynd JW,Drake-Holland AJ,Noble MI

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：AIMS:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact of TGF-beta1 on contractile function of ventricular myocytes is incompletely understood. METHODS AND RESULTS:Reacti...

journal_title：Cardiovascular research

authors： Li S,Li X,Zheng H,Xie B,Bidasee KR,Rozanski GJ

更新日期：2008-01-01 00:00:00