ATP antagonism of thrombin-induced endothelial barrier permeability.

abstract：OBJECTIVES:Natural angiogenesis has been shown to be impaired in spontaneously hypertensive rats (SHR). The purpose of this study was to determine whether pathological angiogenesis in the setting of tissue ischemia is also impaired in SHR, and to what extent it is modified by angiotensin-converting enzyme (ACE) inhibit...

journal_title：Cardiovascular research

authors： Takeshita S,Tomiyama H,Yokoyama N,Kawamura Y,Furukawa T,Ishigai Y,Shibano T,Isshiki T,Sato T

更新日期：2001-11-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：:To determine the effect of an anteroseptal myocardial infarction on right ventricular systolic and diastolic function, we studied 12 pigs before and 1 h after left anterior descending coronary artery occlusion. Total arterial occlusion was achieved by the percutaneous, transcatheter placement of a 1 mm Teflon plug int...

journal_title：Cardiovascular research

authors： Lancaster LD,Kern KB,Morrison DA,Olajos M,Goldman S

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situati...

journal_title：Cardiovascular research

authors： Hale SL,Kloner RA

更新日期：1998-12-01 00:00:00

abstract：:Arterial blood pressures were measured simultaneously in the thoracic and abdominal aortas in the same conscious rats. Intravenous administration of sodium nitroprusside caused a greater fall in systolic blood pressure in the abdominal aorta than in the thoracic aorta, whereas intravenous administration of methoxamine...

journal_title：Cardiovascular research

authors： Gardiner SM,Bennett T

更新日期：1986-05-01 00:00:00

abstract：:Mouse models have been frequently used in the study of Chlamydia pneumoniae (also known as Chlamydophila pneumoniae) infections. This gram-negative obligate intracellular bacterium causes respiratory infections, followed by dissemination of the bacterium to various organs throughout the body, including cardiovascular ...

journal_title：Cardiovascular research

authors： de Kruif MD,van Gorp EC,Keller TT,Ossewaarde JM,ten Cate H

更新日期：2005-02-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Catechol O-methyltransferase (COMT) is believed to exert degradative action at high norepinephrine (NE) levels. Although COMT exists in cardiac tissues, the contribution of cardiac COMT activity to regional NE kinetics, particularly in ischemia-induced NE accumulation, remains unclear. We investigated the rol...

journal_title：Cardiovascular research

authors： Fujii T,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...

journal_title：Cardiovascular research

authors： Dai-Do D,Espinosa E,Liu G,Rabelink TJ,Julmy F,Yang Z,Mahler F,Lüscher TF

更新日期：1996-11-01 00:00:00

abstract：AIMS:Diabetes is a major risk factor for cardiovascular diseases. Circulating endothelial microparticles (EMP) are increased in diabetic patients, but their potential contribution in atherogenesis is unclear. We sought to determine the role of EMP derived under high glucose conditions in the development of atherosclero...

journal_title：Cardiovascular research

authors： Jansen F,Yang X,Franklin BS,Hoelscher M,Schmitz T,Bedorf J,Nickenig G,Werner N

更新日期：2013-04-01 00:00:00

abstract：Aims:Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA i...

journal_title：Cardiovascular research

authors： Tan WL,Lim BT,Anene-Nzelu CG,Ackers-Johnson M,Dashi A,See K,Tiang Z,Lee DP,Chua WW,Luu TD,Li PY,Richards AM,Foo RS

更新日期：2017-03-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVES:M cells have been described in many mammalian species. They are thought to be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in action potential duration and in repolarization time. Their role in the human heart is subject to debate. METHODS:We simulated action potent...

journal_title：Cardiovascular research

authors： Conrath CE,Wilders R,Coronel R,de Bakker JM,Taggart P,de Groot JR,Opthof T

更新日期：2004-05-01 00:00:00

abstract：:The cardioprotective effects of mioflazine, a recently developed cardiovascular drug, were investigated in 41 anaesthetised open chest Beagle dogs subjected to 1 h normothermic global myocardial ischaemia. The severity of the model is evidenced by the finding that only one out of 20 control dogs could be weaned from e...

journal_title：Cardiovascular research

authors： Flameng W,Xhonneux R,Van Belle H,Borgers M,Van de Water A,Wouters L,Wijnants J,Thoné F,Van Daele P,Janssen PA

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:Mechanoelectric Feedback, a mechanical intervention inducing an electrical change, is gaining credence as a cause of cardiac arrhythmia in the clinical situation. However, the precise mechanism is unknown. To elucidate this we investigated mechanical and chemical modulation of stretch-induced premature ventri...

journal_title：Cardiovascular research

authors： Dick DJ,Lab MJ

更新日期：1998-04-01 00:00:00

abstract：AIMS:Alterations in cardiac acid-base balance can produce profound impact on excitation-contraction coupling and precipitate cardiac dysfunction and arrhythmias. A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in...

journal_title：Cardiovascular research

authors： Kim HJ,Myers R,Sihn CR,Rafizadeh S,Zhang XD

更新日期：2013-12-01 00:00:00

abstract：:Angiotensin II has been implicated as an important factor in cardiac remodeling, particularly in the development of pathological left ventricular hypertrophy. It is generally assumed that angiotensin II is able to alter the phenotype of cardiac myocytes and fibroblasts, and several experiments have suggested that this...

journal_title：Cardiovascular research

authors： Bouzegrhane F,Thibault G

更新日期：2002-02-01 00:00:00

abstract：:Eighty-one consecutive patients representing a wide clinical spectrum were studied to assess the degree of limitation of the atrial extrastimulus technique for measurement of atrioventricular node refractoriness; and, to determine the relationship between conductivity and functional refractoriness of the atrioventricu...

journal_title：Cardiovascular research

authors： Wyse DG

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that nitric oxide (or a related compound) contributes to the coronary vasodilatation during physiological increases of myocardial O2 consumption that occur with exercise. METHODS:Active hyperaemia associated with graded treadmill exercise and coronary reactive hyperaemia we...

journal_title：Cardiovascular research

authors： Altman JD,Kinn J,Duncker DJ,Bache RJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal ('fuzzy-space') [Na] and transiently activate Na/K pump current (I(p)). METHODS AND RESULTS:Initially, Na/K pump activity was characterised in whole-cell voltage-clamped ...

journal_title：Cardiovascular research

authors： Silverman Bd,Warley A,Miller JI,James AF,Shattock MJ

更新日期：2003-03-15 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

journal_title：Cardiovascular research

authors： Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX). METHODS:We investigated the consequences of increased expre...

journal_title：Cardiovascular research

authors： Wagner S,Seidler T,Picht E,Maier LS,Kazanski V,Teucher N,Schillinger W,Pieske B,Isenberg G,Hasenfuss G,Kögler H

更新日期：2003-11-01 00:00:00

abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

journal_title：Cardiovascular research

authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

更新日期：2014-07-01 00:00:00

abstract：:Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of c...

journal_title：Cardiovascular research

authors： Carey RA,Tipton CM,Lund DR

更新日期：1976-05-01 00:00:00

abstract：AIMS:Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear. METHODS AND RESULTS:Neither overexpression of CETP nor treatment with CETP inhibitor Torcetrapib ...

journal_title：Cardiovascular research

authors： Tchoua U,D'Souza W,Mukhamedova N,Blum D,Niesor E,Mizrahi J,Maugeais C,Sviridov D

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Our aim was to determine in desmin homozygous mutant mice the viscoelastic properties, the mechanical strength and the structure of the carotid artery. METHODS:To assess the viscoelastic properties of large arteries, we have performed an in vivo analysis of the diameter-, and distensibility-pressure curves o...

journal_title：Cardiovascular research

authors： Lacolley P,Challande P,Boumaza S,Cohuet G,Laurent S,Boutouyrie P,Grimaud JA,Paulin D,Lamazière JM,Li Z

更新日期：2001-07-01 00:00:00

abstract：:The heart responds to ischaemic stimuli with release of negative inotropic mediators such as cytokines, platelet-activating factor, oxygen free radicals, arachidonic acids, nitric oxide, adenosine, and still unidentified "cardiodepressant factors" that modulate myocardial performance via autocrine and paracrine coupli...

journal_title：Cardiovascular research

authors： Stangl V,Baumann G,Stangl K,Felix SB

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:Anthracyclines cause apoptotic death in many cell types through activation of the ceramide pathway. We tested the hypothesis that doxorubicin induces cardiac myocyte apoptosis through ceramide generation. METHODS:Adult rat ventricular myocytes were grown in the presence of 10% fetal calf serum, and exposed ...

journal_title：Cardiovascular research

authors： Delpy E,Hatem SN,Andrieu N,de Vaumas C,Henaff M,Rücker-Martin C,Jaffrézou JP,Laurent G,Levade T,Mercadier JJ

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:Conduction of vasoconstrictor and vasodilator responses in the microcirculation involves electrical coupling through gap junction channels among cells of the vascular wall. The present study determined whether reported differences in the properties of conduction along the arterioles of the epithelial hamster...

journal_title：Cardiovascular research

authors： Sandow SL,Looft-Wilson R,Doran B,Grayson TH,Segal SS,Hill CE

更新日期：2003-12-01 00:00:00