Abstract：
:Arterial blood pressures were measured simultaneously in the thoracic and abdominal aortas in the same conscious rats. Intravenous administration of sodium nitroprusside caused a greater fall in systolic blood pressure in the abdominal aorta than in the thoracic aorta, whereas intravenous administration of methoxamine caused a greater rise in systolic blood pressure in the thoracic aorta. Hence baroreflex sensitivities derived from these data (by relating systolic blood pressure to the pulse interval of the succeeding beat) were appreciably different depending on the site of measurement. The changes in diastolic and mean arterial blood pressures induced by the drugs were similar at the two recording sites. It is suggested therefore that cardiac baroreflex sensitivity should be assessed in conscious rats by relating pulse interval to mean arterial blood pressure recorded at a site other than the thoracic aorta since cannulation at that site impairs baroreflex responsiveness.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Gardiner SM,Bennett Tdoi
10.1093/cvr/20.5.379subject
Has Abstractpub_date
1986-05-01 00:00:00pages
379-83issue
5eissn
0008-6363issn
1755-3245journal_volume
20pub_type
杂志文章abstract：:In acute myocardial infarction (MI), reactive oxygen species (ROS) are generated in the ischaemic myocardium especially after reperfusion. ROS directly injure the cell membrane and cause cell death. However, ROS also stimulate signal transduction to elaborate inflammatory cytokines, e.g. tumour necrosis factor-alpha (...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvn335
更新日期：2009-02-15 00:00:00
abstract：OBJECTIVE:The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear. It has been reported that diastolic sarcomere length (SL) fluctuations accompany propagating contractile waves...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2005.07.010
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:Chlamydia pneumoniae infection has been associated with atherosclerosis, although the mechanisms by which C. pneumoniae contribute to atherogenesis remain unclear. Altered production of nitric oxide, a known bactericidal and anti-inflammatory agent, represents one possible mechanistic link. To examine this is...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(03)00389-4
更新日期：2003-10-15 00:00:00
abstract：AIMS:Vascular endothelial growth factors (VEGFs) and their receptors (VEGF-Rs) are among the most powerful factors regulating vascular growth. However, it has remained unknown whether stimulation of VEGF-R1, VEGF-R2 or both of the receptors produces the best angiogenic responses in myocardium. The aim of this study was...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvp382
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:Oxidized low-density lipoproteins (ox-LDL) or their components suppress macrophage inflammatory response by down-regulating cytokine synthesis, nitric oxide synthase and inducible cyclooxygenase (Cox-2). This event is crucial for the pathophysiological process leading to the formation of atherosclerotic plaqu...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(02)00437-6
更新日期：2002-08-01 00:00:00
abstract：:Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-med...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvq105
更新日期：2010-07-15 00:00:00
abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.1.36
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:The aim was to examine the effect of doxorubicin on spontaneous cyclic Ca2+ release from the sarcoplasmic reticulum of skinned fibres, as measured by isometric tension development in EGTA free, Ca2+ free solution. METHODS:Experiments were done on fragments of papillary muscles from the right ventricles of gu...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/26.4.371
更新日期：1992-04-01 00:00:00
abstract：:The theoretical possibilities and the practical limitations of the Xenon-133 (133Xe) method for the study of regional myocardial perfusion in man are discussed. The techniques for data acqusition and processing developed over the past 5 years are described in detail. Illustrative examples of experimental findings are ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/11.4.277
更新日期：1977-07-01 00:00:00
abstract：:Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the associated adaptive compensatory responses, since thrombosis and inflammatory processes are absent in the majority of cases. Aneurysms and dissectio...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvy006
更新日期：2018-03-15 00:00:00
abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1093/cvr/cvu148
更新日期：2014-08-01 00:00:00
abstract：UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performa...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(98)00313-7
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate the changes in beta-adrenoceptor density (Bmax) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopa...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/26.10.968
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/28.10.1586
更新日期：1994-10-01 00:00:00
abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/16.5.233
更新日期：1982-05-01 00:00:00
abstract：OBJECTIVE:The aim was to assess the significance of polymorphonuclear leucocytes on the myocardial capillary permeability to a small hydrophilic indicator, on the vascular tone of the resistance vessels, and on contractile function following ischaemia and reperfusion. METHODS:Open chest, anaesthetised dogs were random...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.7.1288
更新日期：1993-07-01 00:00:00
abstract：:In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 ...
journal_title：Cardiovascular research
pub_type： 历史文章,杂志文章,评审
doi：10.1093/cvr/cvy084
更新日期：2018-07-15 00:00:00
abstract：AIMS:The expression of PUMA (p53-up-regulated modulator of apoptosis), an apoptosis-regulating gene, increases during endoplasmic reticulum stress. The mechanisms by which cyclic stretch influences the regulation of PUMA in vascular smooth muscle cells (VSMCs) during apoptosis remain unclear. We hypothesized that cycli...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvr280
更新日期：2012-01-01 00:00:00
abstract：:The central role of vascular endothelial growth factor (VEGF) in angiogenesis in health and disease makes it attractive both as a therapeutic target for anti-angiogenic drugs and as a pro-angiogenic cytokine for the treatment of ischaemic heart disease. While VEGF binds to two receptor protein tyrosine kinases, VEGFR1...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(00)00268-6
更新日期：2001-02-16 00:00:00
abstract：OBJECTIVE:The aim was to study L type calcium current alterations in relation to the action potential lengthening induced by hypertrophy in isolated cardiomyocytes from the right ventricle of ferret. METHODS:Chronic pulmonary artery constriction was established in adult male ferrets under anaesthesia. Sham operated an...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/26.7.662
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVE:The aim was to clarify the roles of left atrial pressure and ventricular function in the determination of early diastolic filling. METHODS:Various grades of ventricular dysfunction were made in 12 mongrel dogs by coronary microembolization under pentobarbitone anaesthesia. Left atrial pressure was altered by...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/26.2.109
更新日期：1992-02-01 00:00:00
abstract：:The interest in mouse electrophysiology is expanding fast, despite the marked differences between mouse and man. Different methods have become available to analyse the electrical activity in the mouse heart in vivo. The mouse genome can be altered with relative ease, which allows the molecular dissection of the variou...
journal_title：Cardiovascular research
pub_type： 评论,杂志文章,评审
doi：10.1016/s0008-6363(99)00335-1
更新日期：2000-01-01 00:00:00
abstract：:Congestive heart failure may be deemed the epidemic of cardiology in the 21st century in the industrialized part of the world. Although new therapies improving morbidity and mortality from chronic heart failure have emerged it is likely that there is a growing role for digoxin. Thus, digoxin treatment is known to cont...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(02)00466-2
更新日期：2002-09-01 00:00:00
abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/19.2.95
更新日期：1985-02-01 00:00:00
abstract：OBJECTIVE:The aim was to investigate the influence of coronary occlusion on myocardial interstitial noradrenaline levels in the ischaemic and non-ischaemic regions, using the dialysis technique. METHODS:In nine anaesthetised cats, regional ischaemia was produced by occlusion of the left anterior descending coronary ar...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.5.817
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(00)00038-9
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVES:We measured the uptake of technetium-99m tetrofosmin (99m Tc) and thallium-201 (201 TI) in areas of healed transmural myocardial infarction and in the regions of acute peri-infarction ischemia. METHODS:Anesthetised pigs with a 1-month old transmural infarction elicited by permanent ligature of the left ante...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(97)00316-7
更新日期：1998-04-01 00:00:00
abstract：:Diabetes is one of the most prevalent chronic conditions that has a high association with death from cardiovascular disease(s). An impaired cardiac function independent of vascular disease suggests the existence of a primary myocardial defect in diabetes mellitus. We and others have documented that myocardial performa...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(97)00059-x
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:Pericardial effusion has long been associated with low voltage of the surface electrocardiogram and its clinical utility is well known. The cause of this reduced QRS voltage has usually been attributed to short circuiting of the impulses by the pericardial fluid, but its precise mechanism has not been clearl...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.6.1033
更新日期：1993-06-01 00:00:00
