Distribution of fibrinogen and albumin in normal, ischaemic, and necrotic myocardium during the evolution of myocardial infarction: an immunohistochemical study.

abstract：OBJECTIVE:The aim was to investigate how platelet activation during myocardial ischaemia can induce electrophysiological and arrhythmogenic effects, and examine the involvement of different platelet membrane receptors in producing these effects. METHODS:Transmembrane action potentials and electrograms were recorded fr...

journal_title：Cardiovascular research

authors： Flores NA,Goulielmos NV,Seghatchian MJ,Sheridan DJ

更新日期：1994-11-01 00:00:00

abstract：AIMS:To determine the role of gap junctions (GJs) in hypoxic pulmonary vasoconstriction (HPV). METHODS AND RESULTS:Studies were performed in rat isolated intrapulmonary arteries (IPAs) mounted on a myograph and in anaesthetized rats. Hypoxia induced a biphasic HPV response in IPAs preconstricted with prostaglandin F2α...

journal_title：Cardiovascular research

authors： Kizub IV,Strielkov IV,Shaifta Y,Becker S,Prieto-Lloret J,Snetkov VA,Soloviev AI,Aaronson PI,Ward JP

更新日期：2013-08-01 00:00:00

abstract：AIMS:Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to ...

journal_title：Cardiovascular research

authors： Fernández-Mariño AI,Porras-González C,González-Rodríguez P,Selent J,Pastor M,Ureña J,Castellano A,Valverde MA,Fernández-Fernández JM

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:H(2)O(2) can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H(2)O(2)-induced vasoconstriction could be functionally attributed to the activation of P(2)-purinoceptors in rat aorta and to explore its possible signaling mechanisms. METHODS:Is...

journal_title：Cardiovascular research

authors： Shen JZ,Zheng XF,Kwan CY

更新日期：2000-08-18 00:00:00

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E-deficient mice (apoE(-/-)) on a regular diet become hypercholesterolemic and develop atherosclerosis, but endothelium-dependent relaxation remains undisturbed for up to 6 months. We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hyperch...

journal_title：Cardiovascular research

authors： Crauwels HM,Van Hove CE,Holvoet P,Herman AG,Bult H

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

journal_title：Cardiovascular research

authors： Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

更新日期：2006-09-01 00:00:00

abstract：:Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters and stress signals, most notably catecholamines secreted by the sympathetic nervous system. Catecholamines bind β-adrenergic receptors to stimulate cAMP-...

journal_title：Cardiovascular research

authors： Liu Y,Chen J,Fontes SK,Bautista EN,Cheng Z

更新日期：2021-01-23 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

journal_title：Cardiovascular research

authors： Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

更新日期：2008-04-01 00:00:00

abstract：AIMS:Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this A...

journal_title：Cardiovascular research

authors： Ding Y,Li YL,Zimmerman MC,Davisson RL,Schultz HD

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Research in the pathophysiology of ischemia/reperfusion or redox signaling is hindered by lack of simple methodology to measure short-lived oxygen radicals. In the presence of hydroxyl radical ((*)OH), d-phenylalanine (d-Phe) yields para-, meta- and ortho-tyrosine. We have previously demonstrated that d-Phe c...

journal_title：Cardiovascular research

authors： Biondi R,Ambrosio G,Liebgott T,Cardounel AJ,Bettini M,Tritto I,Zweier JL

更新日期：2006-07-15 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：:The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved an...

journal_title：Cardiovascular research

authors： Nattel S

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Growth hormone (GH) is known to induce growth of the normal rat heart. Whether this growth is due solely to hypertrophy of the cardiac myocytes or whether a concomitant hyperplasia of the cardiac myocytes also takes place is currently not known. Therefore, the aim of the present study was to investigate wheth...

journal_title：Cardiovascular research

authors： Brüel A,Christoffersen TE,Nyengaard JR

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Anthracyclines cause apoptotic death in many cell types through activation of the ceramide pathway. We tested the hypothesis that doxorubicin induces cardiac myocyte apoptosis through ceramide generation. METHODS:Adult rat ventricular myocytes were grown in the presence of 10% fetal calf serum, and exposed ...

journal_title：Cardiovascular research

authors： Delpy E,Hatem SN,Andrieu N,de Vaumas C,Henaff M,Rücker-Martin C,Jaffrézou JP,Laurent G,Levade T,Mercadier JJ

更新日期：1999-08-01 00:00:00

abstract：:Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the associated adaptive compensatory responses, since thrombosis and inflammatory processes are absent in the majority of cases. Aneurysms and dissectio...

journal_title：Cardiovascular research

authors： Michel JB,Jondeau G,Milewicz DM

更新日期：2018-03-15 00:00:00

abstract：:Pressure--diameter loops were generated in normal, conscious dogs during left ventricular contraction by means of endocardial ultrasonic gauges and micromanometers. Studies were made in the control state, during volume and pressure loading, and during enhancement of contractility. The diameter at the end of ejection w...

journal_title：Cardiovascular research

authors： Mahler F,Covell JW,Ross J Jr

更新日期：1975-07-01 00:00:00

abstract：AIMS:Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hypertrophy, and a high...

journal_title：Cardiovascular research

authors： Wenzel P,Schuhmacher S,Kienhöfer J,Müller J,Hortmann M,Oelze M,Schulz E,Treiber N,Kawamoto T,Scharffetter-Kochanek K,Münzel T,Bürkle A,Bachschmid MM,Daiber A

更新日期：2008-11-01 00:00:00

abstract：AIMS:This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart. METHODS AND RESULTS:The expression of the Gjb6 gene in the mouse heart was investigated by RT-PCR and sequencing of amplified cDNA fragments. The sites of Gjb6...

journal_title：Cardiovascular research

authors： Gros D,Théveniau-Ruissy M,Bernard M,Calmels T,Kober F,Söhl G,Willecke K,Nargeot J,Jongsma HJ,Mangoni ME

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Polymorphic ventricular tachycardias (PVT) occur spontaneously in canine hearts under the combination of D-sotalol (S), bradycardia and phenylephrine (PE). We investigated the hypotheses that: (1) the activation patterns of the initial PVT beats would be consistent with an origin in the ventricular conduction...

journal_title：Cardiovascular research

authors： Derakhchan K,Cardinal R,Brunet S,Klug D,Pharand C,Kuś T,Sasyniuk BI

更新日期：1998-06-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：:To provide further evidence that the veratrum alkaloids' mechanical, positive inotropic effect and not their chemical depolarising action predominates in initiating the left ventricular mechanoreceptor (including the Bezold) reflex the effect of intracoronary KCl, a chemical depolarising agent like the veratrum alkalo...

journal_title：Cardiovascular research

authors： Estrin JA,Wahler GM,Booth AM,Swayze CR,Fox IJ

更新日期：1984-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00

abstract：AIMS:Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) currents have never been studied in these two vessels. Our study was init...

journal_title：Cardiovascular research

authors： Smirnov SV,Loutzenhiser K,Loutzenhiser R

更新日期：2013-02-01 00:00:00

abstract：:Regional distribution of myocardial blood flow (MBF) was examined in eight normal and nine pulmonary artery banded (PAB) pigs before and during pacing induced tachycardia (heart rates: 175, 225 and 275 beats X min-1) as well as during iv adenosine infusion (1.5 mg X kg-1 X min-1; maximal coronary vasodilatation) using...

journal_title：Cardiovascular research

authors： Manohar M

更新日期：1985-02-01 00:00:00

abstract：AIMS:Alterations in cardiac acid-base balance can produce profound impact on excitation-contraction coupling and precipitate cardiac dysfunction and arrhythmias. A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in...

journal_title：Cardiovascular research

authors： Kim HJ,Myers R,Sihn CR,Rafizadeh S,Zhang XD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Unidirectional conduction block (UCB) and reentry may occur as a consequence of an abrupt tissue expansion and a related change in the electrical load. The aim of this study was to evaluate critical dimensions of the tissue necessary for establishing UCB in heart cell culture. METHODS:Neonatal rat heart cell...

journal_title：Cardiovascular research

authors： Fast VG,Kléber AG

更新日期：1995-05-01 00:00:00