The L type calcium current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart.

abstract：OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

journal_title：Cardiovascular research

authors： Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

更新日期：2002-08-01 00:00:00

abstract：AIMS:We analysed the possible protective role of human endothelial (EPCs) and smooth muscle (SPCs) progenitor cells on atherosclerosis development in apoE(-/-)RAG2(-/-) mice. We determined plasma levels of SPCs in coronary patients. METHODS AND RESULTS:ApoE(-/-)RAG2(-/-) mice received four intravenous injections of sa...

journal_title：Cardiovascular research

authors： Zoll J,Fontaine V,Gourdy P,Barateau V,Vilar J,Leroyer A,Lopes-Kam I,Mallat Z,Arnal JF,Henry P,Tobelem G,Tedgui A

更新日期：2008-02-01 00:00:00

abstract：:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blo...

journal_title：Cardiovascular research

authors： Nyborg NC,Mulvany MJ

更新日期：1985-09-01 00:00:00

abstract：:The effect of adding fibrinolytic to penicillin therapy in experimentally induced streptococcal bacterial endocarditis has been studied in the rabbit. In 9 day old infected lesions, the vegetations could be substantially reduced in size after a 3 day course of intravenous streptokinase. Quantitative microbiological te...

journal_title：Cardiovascular research

authors： Johnson CE,Dewar HA,Aherne WA

更新日期：1980-08-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The aim was to study the contractility of the conduit coronary artery to vasoactive agents in developing and established volume overload cardiac hypertrophy and to compare it with structural alterations in the artery. METHODS:Aortic valve insufficiency in rabbits was used to produce a volume overloaded heart...

journal_title：Cardiovascular research

authors： Gerová M,Holécyová A,Kristek F,Fízel' A,Fízel'ová A

更新日期：1993-11-01 00:00:00

abstract：:Controversy exists as to whether the diabetic heart is more or less sensitive to ischemic injury. Although a considerable number of experimental studies have directly determined the effects of ischemia on the diabetic heart, there is still no general agreement as to whether metabolic changes within the myocardium cont...

journal_title：Cardiovascular research

authors： Feuvray D,Lopaschuk GD

更新日期：1997-04-01 00:00:00

abstract：:The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late...

journal_title：Cardiovascular research

authors： Takemura G,Nakagawa M,Kanamori H,Minatoguchi S,Fujiwara H

更新日期：2009-07-15 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：:The importance of the vascular adventitia is increasingly being recognized not only in vascular disease but also in normal maintenance and homeostasis of vessels. Activation of the adventitia and its resident fibrocytic cells in response to injury, stretch, cytokines, and hormones has been shown to stimulate different...

journal_title：Cardiovascular research

authors： Haurani MJ,Pagano PJ

更新日期：2007-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate. DESIGN:Diastolic left atrial and left ventricular pressures were recorded at high sensitivity (40 mm Hg = 10 mm recorded deflection) ...

journal_title：Cardiovascular research

authors： Carmeliet P,Aubert A,Van de Werf F,De Geest H

更新日期：1990-07-01 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：OBJECTIVE:The aim was to determine the ionic basis of action potential lengthening associated with cardiac hypertrophy. METHODS:Action potentials and ionic currents of left ventricular myocytes isolated from normal and hypertrophied hearts were recorded with patch pipettes. Since cardiac hypertrophy is a time dependen...

journal_title：Cardiovascular research

authors： Cerbai E,Barbieri M,Li Q,Mugelli A

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM). METHODS:We studied 19 conscious, instrumented dogs with pacing-induced D...

journal_title：Cardiovascular research

authors： Nikolaidis LA,Hentosz T,Doverspike A,Huerbin R,Stolarski C,Shen YT,Shannon RP

更新日期：2002-02-01 00:00:00

abstract：AIMS:In developing blood vessel networks, the overall level of vessel branching often correlates with angiogenic sprout initiations, but in some pathological situations, increased sprout initiations paradoxically lead to reduced vessel branching and impaired vascular function. We examine the hypothesis that defects in ...

journal_title：Cardiovascular research

authors： Chappell JC,Cluceru JG,Nesmith JE,Mouillesseaux KP,Bradley VB,Hartland CM,Hashambhoy-Ramsay YL,Walpole J,Peirce SM,Mac Gabhann F,Bautch VL

更新日期：2016-07-01 00:00:00

abstract：AIMS:The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and concentric hypertrop...

journal_title：Cardiovascular research

authors： Dodd MS,Ball DR,Schroeder MA,Le Page LM,Atherton HJ,Heather LC,Seymour AM,Ashrafian H,Watkins H,Clarke K,Tyler DJ

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal ('fuzzy-space') [Na] and transiently activate Na/K pump current (I(p)). METHODS AND RESULTS:Initially, Na/K pump activity was characterised in whole-cell voltage-clamped ...

journal_title：Cardiovascular research

authors： Silverman Bd,Warley A,Miller JI,James AF,Shattock MJ

更新日期：2003-03-15 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

journal_title：Cardiovascular research

authors： Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

更新日期：1995-08-01 00:00:00

abstract：:The static mechanical properties of major branches of the human arteries (common carotid artery, abdominal aorta, femoral artery, and brachial artery) were studied in 39 subjects, aged 6-81 years, using an ultrasonic phase locked echo tracking system that allows continuous transcutaneous measurement of the diameter of...

journal_title：Cardiovascular research

authors： Kawasaki T,Sasayama S,Yagi S,Asakawa T,Hirai T

更新日期：1987-09-01 00:00:00

abstract：:Injudicious selection of a saphenous vein graft can adversely affect the the late postoperative patency of the proximal coronary artery which it bypasses. The purpose of this investigation was to deduce an upper bound for graft diameter, at small angle of distal anastomosis, below which the stenosed artery will remain...

journal_title：Cardiovascular research

authors： Moskowitz SE,Lewis BS,Milo S,Amar R

更新日期：1979-07-01 00:00:00

abstract：:In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 ...

journal_title：Cardiovascular research

authors： Erdmann J,Kessler T,Munoz Venegas L,Schunkert H

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...

journal_title：Cardiovascular research

authors： Doubell AF,Lazure C,Charbonneau C,Thibault G

更新日期：1993-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether taurine influences the membrane surface charges in cardiac muscle. DESIGN:Screening of the negative charges at the outside surface of the membrane results in a shift of the steady state inactivation of the sodium system towards less negative potentials. This feature was...

journal_title：Cardiovascular research

authors： Dumaine R,Schanne OF,Ruiz-Petrich E

更新日期：1990-11-01 00:00:00

abstract：:Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals ...

journal_title：Cardiovascular research

authors： Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

更新日期：1975-01-01 00:00:00

abstract：:Angiotensin II (AII) plays a critical role in cardiac remodeling. This peptide promotes cardiac myocyte hypertrophy and cardiac fibroblast interstitial fibrotic changes associated with left ventricular hypertrophy, post myocardial infarction remodeling and congestive heart failure. AII mediates cardiac myocyte hypertr...

journal_title：Cardiovascular research

authors： Schnee JM,Hsueh WA

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...

journal_title：Cardiovascular research

authors： Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the ventricular expression of brain natriuretic peptide (BNP) in the transplanted human heart. METHODS:Serial right ventricular biopsies (n = 68) and plasma samples (n = 68) were obtained for measurement of BNP and atrial natriuretic peptide (ANP) from 14 orthotopic cardiac transplant ...

journal_title：Cardiovascular research

authors： Ationu A,Burch M,Singer D,Littleton P,Carter N

更新日期：1993-02-01 00:00:00

abstract：:Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

journal_title：Cardiovascular research

authors： Zhu H,Fan GC

更新日期：2012-05-01 00:00:00

abstract：:The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases such as diabetes. Many drugs produce a small but rep...

journal_title：Cardiovascular research

authors： Roden DM

更新日期：2019-04-15 00:00:00

abstract：ABSTRACT:Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an overwhelming host response to infection resulting in organ failure. The endothelium is an active contributor to sepsis and as such represents a major target for therapy. During sepsis, endothelial cells amplify the immune response...

journal_title：Cardiovascular research

authors： Dolmatova EV,Wang K,Mandavilli R,Griendling KK

更新日期：2021-01-01 00:00:00