Abstract:
OBJECTIVE:The aim was to assess the significance of polymorphonuclear leucocytes on the myocardial capillary permeability to a small hydrophilic indicator, on the vascular tone of the resistance vessels, and on contractile function following ischaemia and reperfusion. METHODS:Open chest, anaesthetised dogs were randomised to treatment with polyclonal antibody against polymorphonuclear leucocytes (anti-PMN group) or non-specific antibody (control group), and subjected to 40 min of coronary occlusion followed by 3 h of reperfusion. The capillary extraction fraction and the myocardial plasma flow rate were quantitated in vivo by intracoronary indicator bolus injection and external registration of the washout, and the capillary permeability-surface area product was calculated. Postischaemic vasodilator tone in the myocardial resistance vessels was measured by the local 133xenon washout method. RESULTS:20 dogs were included (10 in each group), and 13 dogs completed the ischaemia-reperfusion protocol (anti-PMN group, n = 7; control group, n = 6). In the anti-PMN group, blood polymorphonuclear leucocyte counts were reduced to a minimum of 15% of pretreatment values. After ischaemia and 5 min reperfusion, the capillary extraction increased by 17% in the control group but decreased by 22% in the anti-PMN group (p < 0.05). The corresponding capillary permeability-surface area product increased by 22% in the control group, but decreased by 16% in the anti-PMN group (p < 0.05). Neither maximum myocardial plasma flow during reactive hyperaemia nor contractile function were influenced by anti-PMN treatment. CONCLUSIONS:Polymorphonuclear leucocytes appear to participate in the increase in myocardial capillary permeability observed early after reperfusion following a 40 min period of ischaemia, but do not influence postischaemic vascular tone or postischaemic contractile function. During normal physiological conditions reduction of the circulating polymorphonuclear leucocyte counts did not induce significant changes in myocardial capillary permeability.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Svendsen JH,Hansen PR,Ali S,Baandrup U,Haunsø Sdoi
10.1093/cvr/27.7.1288subject
Has Abstractpub_date
1993-07-01 00:00:00pages
1288-94issue
7eissn
0008-6363issn
1755-3245journal_volume
27pub_type
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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doi:10.1093/cvr/16.1.47
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doi:10.1093/cvr/26.3.250
更新日期:1992-03-01 00:00:00
abstract::The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...
journal_title:Cardiovascular research
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更新日期:1987-11-01 00:00:00
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/17.2.88
更新日期:1983-02-01 00:00:00
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更新日期:2021-01-01 00:00:00
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更新日期:2011-08-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/10.3.359
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更新日期:1987-12-01 00:00:00
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更新日期:2008-02-01 00:00:00
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更新日期:2018-04-01 00:00:00
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doi:10.1016/j.cardiores.2006.03.017
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The aim was to examine ventricular brain natriuretic peptide (B-type natriuretic peptide, BNP) gene expression and to determine its relationship with ventricular BNP and circulating BNP levels in paediatric cardiac transplant recipients, over a three year period after transplantation. METHODS:Total RNA extra...
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doi:10.1093/cvr/27.12.2135
更新日期:1993-12-01 00:00:00
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doi:10.1016/j.cardiores.2004.03.016
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvr161
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of the Na, K pump current (I(p)) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate whether I(p) contributes to the changes in APD and ERP associated with chronic atrial fibrillation (AF). METHODS:Action potentials...
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00