Abstract:
OBJECTIVES:We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF). METHODS:We measured renal sympathetic nerve activity (RSNA) in response to graded hypoxia before and after intravenous administration of Ang II (20 ng/kg/min, i.v. 30 min) or AT1 receptor antagonist (L-158,809, 0.33 mg/kg, i.v.) in conscious sham and pacing-induced CHF rabbits. We also investigated the effects of Ang II (100 pM) and L-158,809 (1 microM) on CB chemoreceptor activity in vascularly isolated-perfused CB preparations from sham and CHF rabbits. RESULTS:Ang II enhanced hypoxia-induced RSNA increases in sham rabbits but not in CHF rabbits. Conversely, L-158,809 attenuated hypoxia-induced responses in RSNA in CHF rabbits but not in sham rabbits. Using RT-PCR, Western blotting, and immunocytochemistry, we found that the mRNA and protein expression of AT1 receptor in the CB from CHF rabbits were greater than that in sham rabbits. CB chemoreceptor afferent activity during normoxia and graded hypoxia was increased in CHF rabbits compared with sham rabbits. Ang II increased the response of CB chemoreceptors to hypoxia in sham rabbits but not CHF rabbits. L-158,809 decreased CB chemoreceptor responses to hypoxia in CHF rabbits but not in sham rabbits. CONCLUSIONS:These results indicate that elevation of Ang II and concomitant upregulation of AT1 receptor in the CB contribute to the increased CB chemoreceptor activity and enhanced peripheral chemoreflex function in CHF.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Li YL,Xia XH,Zheng H,Gao L,Li YF,Liu D,Patel KP,Wang W,Schultz HDdoi
10.1016/j.cardiores.2006.03.017subject
Has Abstractpub_date
2006-07-01 00:00:00pages
129-38issue
1eissn
0008-6363issn
1755-3245pii
S0008-6363(06)00144-1journal_volume
71pub_type
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更新日期:2007-09-01 00:00:00
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更新日期:2005-06-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:1979-05-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:1986-02-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2014-11-01 00:00:00
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