Abstract:
:To examine how end systole differs from end ejection and also whether the slope of the end systolic pressure-volume relation can be approximated to that of the end ejection pressure-volume relation, nine isolated, perfused, paced canine hearts ejecting into a hydraulic loading system that simulated the aortic input impedance of a dog's arterial tree were studied. To measure left ventricular volume changes the heart was placed in a plethysmograph. Peripheral resistance (Rp) and arterial compliance (C) were independently varied from 1.9 (Rp = 1.9) to 3.3, 6.4, and 9.6 X 10(8) Pa.m-3.s (Rp run) with a constant value of compliance 1.3 X 10(-9) Pa-1.m3 (C = 1.3), and from C = 0.4 to C = 0.8, C = 1.3 and C = 2.3 (C run) with a constant value of resistance (Rp = 6.4). Five pressure-volume loops were obtained by changing the end diastolic volume at each value of compliance and peripheral resistance. It was clearly shown that ventricular ejection continued after end systole and the time duration between end systole and end ejection became longer with increasing arterial compliance (24(4) at C = 0.4 vs 49(4) ms at C = 2.3, p less than 0.001), while the time duration between end diastole and end systole was constant regardless of afterload impedance change. Regarding the left ventricular pressure-volume relation the end systolic relation was almost linear (r greater than or equal to 0.98) and the slope was not significantly affected by change in any afterload impedance tested. End ejection pressure-volume relation was also linear (r greater than or equal to 0.97) and the slopes in the peripheral resistance and compliance runs were lower than those of the end systolic pressure-volume relation in each corresponding run. The former slopes decreased at smaller values of Rp or larger values of C--namely, 4.4(0.6) at Rp = 9.6 vs 3.6(0.6) at Rp = 1.9, p less than 0.05; 4.8(0.6) at C = 0.4 vs 3.1(0.5) mmHg.ml-1 at C = 2.3, p less than 0.001. Thus it is concluded that end ejection is usually different from end systole and the time difference between them is affected by changes in arterial compliance. In addition, the slope of end ejection pressure-volume relation was dependent on the changes in afterload impedance and cannot be approximated to that of the end systolic pressure-volume relation.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Nishioka O,Maruyama Y,Ashikawa K,Isoyama S,Satoh S,Suzuki H,Watanabe J,Watanabe H,Shimizu Y,Ino-Oka Edoi
10.1093/cvr/21.2.107subject
Has Abstract,Author List Incompletepub_date
1987-02-01 00:00:00pages
107-18issue
2eissn
0008-6363issn
1755-3245journal_volume
21pub_type
杂志文章abstract:OBJECTIVES:Conduction of vasoconstrictor and vasodilator responses in the microcirculation involves electrical coupling through gap junction channels among cells of the vascular wall. The present study determined whether reported differences in the properties of conduction along the arterioles of the epithelial hamster...
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更新日期:2003-12-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:1997-12-01 00:00:00
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doi:10.1093/cvr/25.3.198
更新日期:1991-03-01 00:00:00
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
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更新日期:1987-12-01 00:00:00
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更新日期:1985-09-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2004-11-01 00:00:00
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doi:
更新日期:1996-10-01 00:00:00
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更新日期:2018-07-15 00:00:00
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更新日期:1989-08-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2008-01-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2007-05-01 00:00:00
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更新日期:2007-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/25.10.869
更新日期:1991-10-01 00:00:00