Diabetes mellitus attenuates the repolarization reserve in mammalian heart.

abstract：AIMS:To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS AND RESULTS:SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(...

journal_title：Cardiovascular research

authors： Stokke MK,Hougen K,Sjaastad I,Louch WE,Briston SJ,Enger UH,Andersson KB,Christensen G,Eisner DA,Sejersted OM,Trafford AW

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

journal_title：Cardiovascular research

authors： Marganski WA,De Biase VM,Burgess ML,Dembo M

更新日期：2003-12-01 00:00:00

abstract：:Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue devi...

journal_title：Cardiovascular research

authors： Lab MJ,Gartside I,Wassermann S

更新日期：1983-12-01 00:00:00

abstract：:Injudicious selection of a saphenous vein graft can adversely affect the the late postoperative patency of the proximal coronary artery which it bypasses. The purpose of this investigation was to deduce an upper bound for graft diameter, at small angle of distal anastomosis, below which the stenosed artery will remain...

journal_title：Cardiovascular research

authors： Moskowitz SE,Lewis BS,Milo S,Amar R

更新日期：1979-07-01 00:00:00

abstract：:Muscle tissue in atrioventricular (A-V) cardiac valve leaflets was studied in 35 human hearts and was found to be more prominent in the anterior leaflet of the mitral (MAL) than in the other valve leaflets. From serial sectioning and wax model reconstruction, the anatomic arrangement of the muscle in the MAL indicates...

journal_title：Cardiovascular research

authors： Boucek RJ,Boucková B,Levy S

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transg...

journal_title：Cardiovascular research

authors： Maier LS,Wahl-Schott C,Horn W,Weichert S,Pagel C,Wagner S,Dybkova N,Müller OJ,Näbauer M,Franz WM,Pieske B

更新日期：2005-09-01 00:00:00

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：AIMS:Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hypertrophy, and a high...

journal_title：Cardiovascular research

authors： Wenzel P,Schuhmacher S,Kienhöfer J,Müller J,Hortmann M,Oelze M,Schulz E,Treiber N,Kawamoto T,Scharffetter-Kochanek K,Münzel T,Bürkle A,Bachschmid MM,Daiber A

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：AIMS:The risk of mortality from the coronavirus disease that emerged in 2019 (COVID-19) is increased by comorbidity from cardiovascular and pulmonary diseases. Air pollution also causes excess mortality from these conditions. Analysis of the first severe acute respiratory syndrome coronavirus (SARS-CoV-1) outcomes in 2...

journal_title：Cardiovascular research

authors： Pozzer A,Dominici F,Haines A,Witt C,Münzel T,Lelieveld J

更新日期：2020-12-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers responsible for AF, as well as the fundamental mechanisms governing th...

journal_title：Cardiovascular research

authors： Alvarez-Franco A,Rouco R,Ramirez RJ,Guerrero-Serna G,Tiana M,Cogliati S,Kaur K,Saeed M,Magni R,Enriquez JA,Sanchez-Cabo F,Jalife J,Manzanares M

更新日期：2020-10-29 00:00:00

abstract：:Mouse models have been frequently used in the study of Chlamydia pneumoniae (also known as Chlamydophila pneumoniae) infections. This gram-negative obligate intracellular bacterium causes respiratory infections, followed by dissemination of the bacterium to various organs throughout the body, including cardiovascular ...

journal_title：Cardiovascular research

authors： de Kruif MD,van Gorp EC,Keller TT,Ossewaarde JM,ten Cate H

更新日期：2005-02-01 00:00:00

abstract：Aims:The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis and acute coronary syndromes (ACS). However, its role in arterial thrombus formation remains unknown. We investigated whether LOX-1 plays a role in arteria...

journal_title：Cardiovascular research

authors： Akhmedov A,Camici GG,Reiner MF,Bonetti NR,Costantino S,Holy EW,Spescha RD,Stivala S,Schaub Clerigué A,Speer T,Breitenstein A,Manz J,Lohmann C,Paneni F,Beer JH,Lüscher TF

更新日期：2017-04-01 00:00:00

abstract：AIMS:A problem in generating artificial tissues is supplying nutrients to cells within 3D constructs. The use of a decellularized biological vascularized matrix with preserved pedicles (BioVaM), as a scaffold, appears to aid the generation of perfusable tissue constructs in vitro. To prevent vessel occlusion upon impla...

journal_title：Cardiovascular research

authors： Bär A,Dorfman SE,Fischer P,Hilfiker-Kleiner D,Cebotari S,Tudorache I,Suprunov M,Haverich A,Hilfiker A

更新日期：2010-03-01 00:00:00

abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

journal_title：Cardiovascular research

authors： Sawanobori T,Hirano Y,Hiraoka M

更新日期：1987-11-01 00:00:00

abstract：AIMS:Alterations in cardiac acid-base balance can produce profound impact on excitation-contraction coupling and precipitate cardiac dysfunction and arrhythmias. A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in...

journal_title：Cardiovascular research

authors： Kim HJ,Myers R,Sihn CR,Rafizadeh S,Zhang XD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

journal_title：Cardiovascular research

authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

更新日期：2007-09-01 00:00:00

abstract：:18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In eight normal patients...

journal_title：Cardiovascular research

authors： Merillon JP,Motte G,Aumont MC,Masquet C,Lecarpentier Y,Gourgon R

更新日期：1979-06-01 00:00:00

abstract：AIMS:A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling ...

journal_title：Cardiovascular research

authors： Rossitto G,Maiolino G,Lerco S,Ceolotto G,Blackburn G,Mary S,Antonelli G,Berton C,Bisogni V,Cesari M,Seccia TM,Lenzini L,Pinato A,Montezano A,Touyz RM,Petrie MC,Daly R,Welsh P,Plebani M,Rossi GP,Delles C

更新日期：2020-07-16 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：:Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribut...

journal_title：Cardiovascular research

authors： Dormans TP,Pickkers P,Russel FG,Smits P

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...

journal_title：Cardiovascular research

authors： Dai-Do D,Espinosa E,Liu G,Rabelink TJ,Julmy F,Yang Z,Mahler F,Lüscher TF

更新日期：1996-11-01 00:00:00

abstract：AIMS:Human congenital heart disease linked to mutations in the homeobox transcription factor, NKX2-5, is characterized by cardiac anomalies, including atrial and ventricular septal defects as well as conduction and occasional defects in contractility. In the mouse, homozygous germline deletion of Nkx2-5 gene results in...

journal_title：Cardiovascular research

authors： Terada R,Warren S,Lu JT,Chien KR,Wessels A,Kasahara H

更新日期：2011-07-15 00:00:00

abstract：OBJECTIVE:Myocardial cellular electrophysiology and intracellular Ca2+ regulation are altered in heart failure. The extent of these changes may vary within the layers of the ventricular wall. To examine this, cell size, action potential and intracellular Ca2+ transient characteristics (Fura-2) were measured in single c...

journal_title：Cardiovascular research

authors： McIntosh MA,Cobbe SM,Smith GL

更新日期：2000-01-14 00:00:00

abstract：AIMS:G-protein-coupled receptors (GPCRs) modulate vascular tone, at least in part, via matrix metalloproteinase (MMP) transactivation of the epidermal growth factor receptor (EGFR). We previously have identified novel signalling pathways downstream of the EGFR suggestive of mitogen-activated protein kinase and mitochon...

journal_title：Cardiovascular research

authors： Nagareddy PR,Chow FL,Hao L,Wang X,Nishimura T,MacLeod KM,McNeill JH,Fernandez-Patron C

更新日期：2009-12-01 00:00:00

abstract：:Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

journal_title：Cardiovascular research

authors： Patel AP,Natarajan P

更新日期：2019-04-15 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：:To investigate cardiovascular changes in experimental acromegaly, a growth hormone-secreting tumour (MtT-W-15) was implanted in adult female rats. Somatic and tumour growth occurred steadily during the 8 week study period, as did an increase in serum growth hormone titre. Weight of left ventricle and right ventricle i...

journal_title：Cardiovascular research

authors： Penney DG,Dunbar JC Jr,Baylerian MS

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...

journal_title：Cardiovascular research

authors： Philipp S,Yang XM,Cui L,Davis AM,Downey JM,Cohen MV

更新日期：2006-05-01 00:00:00