Acute haemodynamic effect of taurine on hearts in vivo with normal and depressed myocardial function.

abstract：OBJECTIVE:Stretch-activated cation channels (SAC) have been suggested to act as endothelial mechanosensors for hemodynamic forces. Ca(2+) influx through SAC could induce an intracellular Ca(2+) signal stimulating Ca(2+)-dependent synthesis of vasodilators like NO, prostacyclin, or EDHF. In the present study we tested w...

journal_title：Cardiovascular research

authors： Brakemeier S,Eichler I,Hopp H,Köhler R,Hoyer J

更新日期：2002-01-01 00:00:00

abstract：:An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the inti...

journal_title：Cardiovascular research

authors： Davis J,Klinowski J,Winlove CP

更新日期：1981-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to explore the relationship between low density lipoprotein (LDL) and dendritic cell (DC) activation, based upon the hypothesis that reactive oxygen species (ROS)-mediated modification of proteins that may be present in local DC microenvironments could be important as mediators...

journal_title：Cardiovascular research

authors： Alderman CJ,Bunyard PR,Chain BM,Foreman JC,Leake DS,Katz DR

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

journal_title：Cardiovascular research

authors： Marganski WA,De Biase VM,Burgess ML,Dembo M

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:We recently showed that mitochondrial coupling factor 6 (CF6) is present as a pressor substance and a prostacyclin inhibitor in systemic circulation. However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and rele...

journal_title：Cardiovascular research

authors： Sasaki S,Osanai T,Tomita H,Matsunaga T,Magota K,Okumura K

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...

journal_title：Cardiovascular research

authors： McIlroy M,O'Rourke M,McKeown SR,Hirst DG,Robson T

更新日期：2006-01-01 00:00:00

abstract：AIMS:Recent immunohistochemical studies observed the loss of plakoglobin (PG) from the intercalated disc (ID) as a hallmark of arrhythmogenic right ventricular cardiomyopathy (ARVC), suggesting a final common pathway for this disease. However, the underlying molecular processes are poorly understood. METHODS AND RESUL...

journal_title：Cardiovascular research

authors： Gehmlich K,Syrris P,Peskett E,Evans A,Ehler E,Asimaki A,Anastasakis A,Tsatsopoulou A,Vouliotis AI,Stefanadis C,Saffitz JE,Protonotarios N,McKenna WJ

更新日期：2011-04-01 00:00:00

abstract：:In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. The use of LTCC Ca(2+) as a multi-dimensional signalling molecule in the heart is complicated by several aspects of ...

journal_title：Cardiovascular research

authors： Shaw RM,Colecraft HM

更新日期：2013-05-01 00:00:00

abstract：AIMS:Recent publications have shed new light on the role of the adaptive and innate immune system in the pathogenesis of hypertension. However, there are limited data whether receptors of the innate immune system may influence blood pressure. Toll-like receptor 4 (TLR4), a pattern recognition receptor, is a key compone...

journal_title：Cardiovascular research

authors： Sollinger D,Eißler R,Lorenz S,Strand S,Chmielewski S,Aoqui C,Schmaderer C,Bluyssen H,Zicha J,Witzke O,Scherer E,Lutz J,Heemann U,Baumann M

更新日期：2014-03-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to determine the changes in the beta adrenergic system induced by cardiac hypertrophy due to valvular aortic stenosis. DESIGN - Density of beta adrenoceptors, cardiac tissue noradrenalime concentrations, coronary blood flow (using radioactive microspheres), and haemodynamic v...

journal_title：Cardiovascular research

authors： Scholz PM,Upsher ME,Eliades D,Kedem J,Weiss HR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To study the intracellular pathways which mediate the inhibitory actions of adenosine on isoprenaline-stimulated calcium current (ICa) in atrioventricular (AV) nodal myocytes. METHODS:The whole-cell patch-clamp technique was used to record ICa from rabbit AV nodal cells, isolated by enzymatic and mechanical ...

journal_title：Cardiovascular research

authors： Martynyuk AE,Kane KA,Cobbe SM,Rankin AC

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：AIMS:Expression of extracellular matrix protein CCN1 is induced in end-stage ischaemic cardiomyopathy in humans, and after cardiac ischaemia and reperfusion in experimental animal models. Despite its well-documented angiogenic activities, CCN1 increases the cytotoxicities of the tumour necrosis factor family cytokines,...

journal_title：Cardiovascular research

authors： Hsu PL,Su BC,Kuok QY,Mo FE

更新日期：2013-04-01 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...

journal_title：Cardiovascular research

authors： Kanno Y,Into T,Lowenstein CJ,Matsushita K

更新日期：2008-01-01 00:00:00

abstract：:Electrophysiologic remodeling is a process whereby heart disease alters the electrophysiologic properties of cardiac tissue. These alterations, in turn, can cause or exacerbate disease-related arrhythmias. Ion channels are the fundamental molecular units underlying cardiac electrophysiology, and it therefore follows t...

journal_title：Cardiovascular research

authors： Roden DM,Kupershmidt S

更新日期：1999-05-01 00:00:00

abstract：CONDENSED ABSTRACT:We analyzed actomyosin cross-bridge kinetics in human atrial and ventricular muscle strip preparations by using sinusoidal length changes from 0.1 to 60 Hz. The minimum stiffness frequency was higher in atrial than in ventricular human myocardium and lower in failing than in non-failing left ventricu...

journal_title：Cardiovascular research

authors： Ruf T,Schulte-Baukloh H,Lüdemann J,Posival H,Beyersdorf F,Just H,Holubarsch C

更新日期：1998-12-01 00:00:00

abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...

journal_title：Cardiovascular research

authors： Teng B,Smith JD,Rosenfeld ME,Robinet P,Davis ME,Morrison RR,Mustafa SJ

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands have been shown to ameliorate a variety of inflammatory conditions. The present study tested the hypothesis that PPAR-gamma ligands reduce experimental autoimmune myocarditis (EAM) associated with inhibition of the expansion and activation...

journal_title：Cardiovascular research

authors： Yuan Z,Liu Y,Liu Y,Zhang J,Kishimoto C,Wang Y,Ma A,Liu Z

更新日期：2003-09-01 00:00:00

abstract：:The renin-angiotensin-aldosterone (RAA) system and the endothelin (ET) system entail the most potent vasopressor mechanisms identified to date. Although they were studied in depth in relation to arterial hypertension and cardiovascular diseases, limited information on their interrelationships in causing hypertension a...

journal_title：Cardiovascular research

authors： Rossi GP,Sacchetto A,Cesari M,Pessina AC

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Migration and proliferation of arterial smooth muscle cells are critical responses during restenosis after balloon angioplasty. We investigated the changes in the expression of Ca(2+) channels and dystrophin, two determinants of contraction, after balloon injury of rat aortas. METHODS:Proliferation and migra...

journal_title：Cardiovascular research

authors： Quignard JF,Harricane MC,Ménard C,Lory P,Nargeot J,Capron L,Mornet D,Richard S

更新日期：2001-01-01 00:00:00

abstract：:Because of ventricular interdependence, part of the measured left ventricular diastolic pressure can be attributed to the right ventricle. Therefore, we examined the hypothesis that left ventricular diastolic properties are modified by alterations in right ventricular compliance and pressure even without a change in r...

journal_title：Cardiovascular research

authors： Santamore WP,Constantinescu M,Vinten-Johansen J,Johnston WE,Little WC

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVES:L-arginine exerts anti-atherosclerotic effects in hypercholesterolaemic rabbits via modulating endogenous NO production. We investigated whether L-arginine inhibits thromboxane formation in vivo and platelet aggregation ex vivo in this animal model. METHODS:The urinary excretion rates of 2,3-dinor-6-keto-PG...

journal_title：Cardiovascular research

authors： Bode-Böger SM,Böger RH,Kienke S,Böhme M,Phivthong-ngam L,Tsikas D,Frölich JC

更新日期：1998-03-01 00:00:00

abstract：:The effect of adding fibrinolytic to penicillin therapy in experimentally induced streptococcal bacterial endocarditis has been studied in the rabbit. In 9 day old infected lesions, the vegetations could be substantially reduced in size after a 3 day course of intravenous streptokinase. Quantitative microbiological te...

journal_title：Cardiovascular research

authors： Johnson CE,Dewar HA,Aherne WA

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). METHODS:Dogs were paced for 3 weeks at 240 BPM to induce heart failure which was confirmed with hemodynamic and echocardiographic measurements. The pacemaker was turned off 30 min prior to the ischemia study. Normal...

journal_title：Cardiovascular research

authors： Hoskins DE,Ignasiak DP,Saganek LJ,Gallagher KP,Peterson JT

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on inf...

journal_title：Cardiovascular research

authors： Bowes J,McDonald MC,Piper J,Thiemermann C

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Increased cardiac collagen is seen in uninephrectomised rats made hypertensive by aldosterone infusion and high salt, with the possibility of a direct effect of aldosterone at the level of the cardiac fibroblast. The aim of this study was to examine the effects of aldosterone, glucocorticoids, and angiotensin...

journal_title：Cardiovascular research

authors： Fullerton MJ,Funder JW

更新日期：1994-12-01 00:00:00

abstract：:Estimation of infarct size from enzyme activities in plasma or serum presupposes known values of circulatory parameters such as the extravascular distribution volume Ve and the permeability constant P for the transport of enzyme between intravascular volume Vi and Ve. In man, parameter values are used that are extrapo...

journal_title：Cardiovascular research

authors： Willems GM,Muijtjens AM,Lambi FH,Hermens WT

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate the hypothesis that the oxygen demand of stimulated myocardium is downregulated and ischaemia avoided when oxygen supply is limited. METHODS:Isoprenaline stimulation during reduced coronary perfusion pressure or moderate coronary hypoxaemia was studied in relation to myocardial oxygen...

journal_title：Cardiovascular research

authors： Lee SC,Downey HF

更新日期：1993-08-01 00:00:00