Up-regulation of endothelial stretch-activated cation channels by fluid shear stress.

abstract：:The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst undergoing coronary angiography. In seven patients C3a levels were raised during this procedure and in three of these the anaphylatoxin was increased between four and tenfold. In four patients C3a...

journal_title：Cardiovascular research

authors： Westaby S,Dawson P,Turner MW,Pridie RB

更新日期：1985-02-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：:Following a myocardial infarction (MI), the immune system helps to repair ischaemic damage and restore tissue integrity, but excessive inflammation has been implicated in adverse cardiac remodelling and development towards heart failure (HF). Pre-clinical studies suggest that timely resolution of inflammation may help...

journal_title：Cardiovascular research

authors： Panahi M,Papanikolaou A,Torabi A,Zhang JG,Khan H,Vazir A,Hasham MG,Cleland JGF,Rosenthal NA,Harding SE,Sattler S

更新日期：2018-09-01 00:00:00

abstract：:The cardiospecificity of the MB isoenzyme of creatine kinase, EC 2.7.3.2, (CK) with its associated diagnostic and research value has resulted in the development of a number of procedures for the separation and quantitation of the three isoenzymes of CK. In our experience methods involving cellulose acetate electrophor...

journal_title：Cardiovascular research

authors： Ogunro EA,Hearse DJ,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：AIMS:Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. METHODS AND RESULTS:Forty Large-White pigs were included. In Study 1...

journal_title：Cardiovascular research

authors： Galán-Arriola C,Villena-Gutiérrez R,Higuero-Verdejo MI,Díaz-Rengifo IA,Pizarro G,López GJ,de Molina-Iracheta A,Pérez-Martínez C,García RD,González-Calle D,Lobo M,Sánchez PL,Oliver E,Córdoba R,Fuster V,Sánchez-González J,I

更新日期：2020-06-29 00:00:00

abstract：AIMS:Autonomic dysfunction can promote atrial fibrillation (AF) and results from AF-related remodelling. N-type Ca2+-channels (NTCCs) at sympathetic nerve terminals mediate Ca2+-entry that triggers neurotransmitter release. AF-associated remodelling plays an important role in AF pathophysiology but the effects of NTCC ...

journal_title：Cardiovascular research

authors： Tajiri K,Guichard JB,Qi X,Xiong F,Naud P,Tardif JC,Costa AD,Aonuma K,Nattel S

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

journal_title：Cardiovascular research

authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

更新日期：1997-06-01 00:00:00

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：:The heart is challenged by a plethora of extracellular stimuli over the course of a normal day, each of which distinctly influences myocardial contractile function. It is therefore not surprising that myocardial metabolism also oscillates in a time-of-day dependent manner. What is becoming increasingly apparent is tha...

journal_title：Cardiovascular research

authors： Bray MS,Young ME

更新日期：2008-07-15 00:00:00

abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

journal_title：Cardiovascular research

authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:To elucidate the effect of selective endothelin ET(A)- and mixed ET(A/B)-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial infarction (MI). METHODS:Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats 12 weeks afte...

journal_title：Cardiovascular research

authors： Bauersachs J,Fraccarollo D,Galuppo P,Widder J,Ertl G

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:There is accumulating evidence that oestrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The aim of this study was to measure the effects of 17 beta-oestradiol on huma...

journal_title：Cardiovascular research

authors： Mügge A,Riedel M,Barton M,Kuhn M,Lichtlen PR

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：:Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent st...

journal_title：Cardiovascular research

authors： Sharma N,Okere IC,Duda MK,Chess DJ,O'Shea KM,Stanley WC

更新日期：2007-01-15 00:00:00

abstract：:Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases which are best known for their ability to proteolyse extracellular matrix proteins throughout the body, including the cardiovascular system. Increased MMP-2 activity has been demonstrated in myocardial ischaemia and reperfusion injury and...

journal_title：Cardiovascular research

authors： Kandasamy AD,Chow AK,Ali MA,Schulz R

更新日期：2010-02-01 00:00:00

abstract：:The effect of digoxin, at two different inotropic levels, was examined in normo- and hyperkalaemic dogs. For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin. ...

journal_title：Cardiovascular research

authors： Goldman RH,Coltart DJ,Schweizer E,Snidow G,Harrison DC

更新日期：1975-07-01 00:00:00

abstract：AIMS:Chronic heart failure is a complex clinical syndrome with impaired myocardial contractility. In failing cardiomyocytes, decreased signalling efficiency between the L-type Ca(2+) channels (LCCs) in the plasma membrane (including transverse tubules, TTs) and the ryanodine receptors (RyRs) in the sarcoplasmic reticul...

journal_title：Cardiovascular research

authors： Zhang HB,Li RC,Xu M,Xu SM,Lai YS,Wu HD,Xie XJ,Gao W,Ye H,Zhang YY,Meng X,Wang SQ

更新日期：2013-05-01 00:00:00

abstract：:Cardiomyocytes are long-lived post-mitotic cells with limited regenerative capacity. Proper cardiomyocyte function depends critically on the maintenance of a healthy homeostasis of protein expression, folding, assembly, trafficking, function, and degradation, together commonly referred to as proteostasis. Impairment o...

journal_title：Cardiovascular research

authors： Zhang D,Hu X,Henning RH,Brundel BJ

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:We studied the effects of temporary myocardial ischemia and reperfusion on myocyte injury and ventricular remodelling in wildtype and intercellular adhesion molecule-1- (ICAM-1) deficient mice. METHODS:ICAM-1-/- and ICAM-1+/+ mice were subjected to 30 min of myocardial ischemia and subsequent reperfusion for...

journal_title：Cardiovascular research

authors： Metzler B,Mair J,Lercher A,Schaber C,Hintringer F,Pachinger O,Xu Q

更新日期：2001-02-01 00:00:00

abstract：AIMS:We investigated the molecular mechanism of rapid-depolarization-induced atrial fibrosis. METHODS AND RESULTS:We used a direct atrial myocyte-fibroblast contact co-culture and a fibroblast-specific transforming growth factor β1 (TGF-β1), connective tissue growth factor (CTGF) and procollagen type I α-1 (COL1A1) lu...

journal_title：Cardiovascular research

authors： Tsai CT,Tseng CD,Hwang JJ,Wu CK,Yu CC,Wang YC,Chen WP,Lai LP,Chiang FT,Lin JL

更新日期：2011-03-01 00:00:00

abstract：AIMS:The effects of serelaxin, a recombinant form of human relaxin-2 peptide, on vascular function in the coronary microvascular and systemic macrovascular circulation remain largely unknown. This mechanistic, clinical study assessed the effects of serelaxin on myocardial perfusion, aortic stiffness, and safety in pati...

journal_title：Cardiovascular research

authors： Corcoran D,Radjenovic A,Mordi IR,Nazir SA,Wilson SJ,Hinder M,Yates DP,Machineni S,Alcantara J,Prescott MF,Gugliotta B,Pang Y,Tzemos N,Semple SI,Newby DE,McCann GP,Squire I,Berry C

更新日期：2021-01-01 00:00:00

abstract：:Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are...

journal_title：Cardiovascular research

authors： Dubey RK,Oparil S,Imthurn B,Jackson EK

更新日期：2002-02-15 00:00:00

abstract：AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...

journal_title：Cardiovascular research

authors： Kanno Y,Into T,Lowenstein CJ,Matsushita K

更新日期：2008-01-01 00:00:00

abstract：:Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in l...

journal_title：Cardiovascular research

authors： Tester DJ,Ackerman MJ

更新日期：2005-08-15 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：AIMS:We analysed the possible protective role of human endothelial (EPCs) and smooth muscle (SPCs) progenitor cells on atherosclerosis development in apoE(-/-)RAG2(-/-) mice. We determined plasma levels of SPCs in coronary patients. METHODS AND RESULTS:ApoE(-/-)RAG2(-/-) mice received four intravenous injections of sa...

journal_title：Cardiovascular research

authors： Zoll J,Fontaine V,Gourdy P,Barateau V,Vilar J,Leroyer A,Lopes-Kam I,Mallat Z,Arnal JF,Henry P,Tobelem G,Tedgui A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Exposure to anoxia has been reported to activate ATP-sensitive potassium (K+(ATP)) channels in isolated ventricular myocytes. We aimed to investigate the mechanisms underlying the anoxia-induced activation of K+(ATP) channels. METHODS:Guinea pig ventricular myocytes were isolated using collagenase digestion....

journal_title：Cardiovascular research

authors： Shigematsu S,Arita M

更新日期：1997-08-01 00:00:00

abstract：AIM:The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia. METHODS AND RESULTS:Blood vessels were obtained from patients or mice and studied in culture. Reverse transcriptase-polymerase chain reaction and immunocytochemistry were used to...

journal_title：Cardiovascular research

authors： Cheong A,Li J,Sukumar P,Kumar B,Zeng F,Riches K,Munsch C,Wood IC,Porter KE,Beech DJ

更新日期：2011-02-01 00:00:00

abstract：:Sudden hypothermia utilising liquid nitrogen has been used for immediate inhibition of metabolic reactions and preservation of labile compounds in heart muscle. It has been suggested that this rapid transfer of tissue into liquid nitrogen, within 1 to 2 s, is essential for accurate assessment of internal milieu condit...

journal_title：Cardiovascular research

authors： Allison TB,Ramey CA,Holsinger JW Jr

更新日期：1978-03-01 00:00:00