Delayed preconditioning of the human myocardium: signal transduction and clinical implications.

abstract：:Sinoatrial conduction times, estimated by premature atrial stimulation, were compared with direct measurement of the sinoatrial conduction time in 15 isolated rabbit sinus node preparations before and after intrasinusal pacemaker shifts induced by cooling. Transmembrane potentials and surface electrograms were recorde...

journal_title：Cardiovascular research

authors： Le Heuzey JY,Guize L,Valty J,Moutet JP,Kouz S,Lavergne T,Boutjdir M,Peronneau P

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect of lowering external potassium on the sensitivity of the normal and hypertrophied rat heart to arrhythmias induced by increases in ventricular wall stress. METHODS:The isolated working heart model was used to compare hypertrophied hearts from the spontaneously hypertensi...

journal_title：Cardiovascular research

authors： Evans SJ,Levi AJ,Jones JV

更新日期：1995-04-01 00:00:00

abstract：AIMS:Exercise capacity is reduced in heart failure (HF) patients, due mostly to skeletal muscle abnormalities including impaired energy metabolism, mitochondrial dysfunction, fibre type transition, and atrophy. Glucagon-like peptide-1 (GLP-1) has been shown to improve exercise capacity in HF patients. We investigated t...

journal_title：Cardiovascular research

authors： Takada S,Masaki Y,Kinugawa S,Matsumoto J,Furihata T,Mizushima W,Kadoguchi T,Fukushima A,Homma T,Takahashi M,Harashima S,Matsushima S,Yokota T,Tanaka S,Okita K,Tsutsui H

更新日期：2016-09-01 00:00:00

abstract：AIMS:Smad7 plays a negative regulatory role in many inflammatory diseases, but its effect on hypertensive disease remains unknown. The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II)-mediated hypertensive cardiac remodelling. METHODS AND RESUL...

journal_title：Cardiovascular research

authors： Wei LH,Huang XR,Zhang Y,Li YQ,Chen HY,Yan BP,Yu CM,Lan HY

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Automatic analysis of the frequency content of the fibrillatory baseline on the surface ECG accurately reflects the average rate of atrial fibrillation (AF). This frequency measurement correlates with the behavior of AF and predicts the response to administration of ibutilide, a new antiarrhythmic drug. Neith...

journal_title：Cardiovascular research

authors： Bollmann A,Sonne K,Esperer HD,Toepffer I,Langberg JJ,Klein HU

更新日期：1999-10-01 00:00:00

abstract：AIMS:As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our aim was to determine the impact of this change on the mechanism underlying vascular tone of pressurized arteries in vitro and in vivo. METHODS AND RESULTS:We used pressurized cerebral and mesenteric arteries in vitro and skele...

journal_title：Cardiovascular research

authors： Howitt L,Kuo IY,Ellis A,Chaston DJ,Shin HS,Hansen PB,Hill CE

更新日期：2013-06-01 00:00:00

abstract：AIMS:In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROS production in fat may attenuate the metabolic syndrome. Activation of mineralocorticoid receptor (MR) promotes inflammation ...

journal_title：Cardiovascular research

authors： Hirata A,Maeda N,Hiuge A,Hibuse T,Fujita K,Okada T,Kihara S,Funahashi T,Shimomura I

更新日期：2009-10-01 00:00:00

abstract：AIMS:Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na, K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R mice) were shown to have elevated cerebrovascular tone ...

journal_title：Cardiovascular research

authors： Staehr C,Rajanathan R,Postnov DD,Hangaard L,Bouzinova EV,Lykke-Hartmann K,Bach FW,Sandow SL,Aalkjaer C,Matchkov VV

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The aim was to estimate the relative contributions of the various intracellular and sarcolemmal systems to the relaxation of the systolic calcium transient. METHODS:The experiments were performed on isolated rat ventricular myocytes. The cells were loaded with the fluorescent indicator indo-1 in order to mea...

journal_title：Cardiovascular research

authors： Negretti N,O'Neill SC,Eisner DA

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the anaesthetised dog. METHODS:Heparin or N-acetylheparin was given in three repeated intravenous doses of 2 mg.kg-1. Drug or...

journal_title：Cardiovascular research

authors： Black SC,Gralinski MR,Friedrichs GS,Kilgore KS,Driscoll EM,Lucchesi BR

更新日期：1995-05-01 00:00:00

abstract：AIMS:in this study, we attempted to detect a recent myocardial ischaemic event using ultrasound molecular imaging (UMI) with microbubbles (MB) targeted to intercellular adhesion molecule-1 (ICAM-1) in the late phase of reperfusion. METHODS AND RESULTS:we created a myocardial ischaemia-reperfusion model in 60 C57/BL ma...

journal_title：Cardiovascular research

authors： Yan Y,Liao Y,Yang L,Wu J,Du J,Xuan W,Ji L,Huang Q,Liu Y,Bin J

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force-frequency relation which is reversed into a negative relation in preparation from failing hearts. Whether or not such relations between ventricular function and heart rate hold true in the i...

journal_title：Cardiovascular research

authors： Neumann T,Ravens U,Heusch G

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:The primary aim of this study was to investigate whether activation of Na influx via voltage-gated Na channels can elevate sub-sarcolemmal ('fuzzy-space') [Na] and transiently activate Na/K pump current (I(p)). METHODS AND RESULTS:Initially, Na/K pump activity was characterised in whole-cell voltage-clamped ...

journal_title：Cardiovascular research

authors： Silverman Bd,Warley A,Miller JI,James AF,Shattock MJ

更新日期：2003-03-15 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The aim was to test for the presence of cAMPi activated and ATPo activated chloride conductances (ICl(cAMP) and ICl(ATP)) in mouse ventricular myocytes. METHODS:Membrane currents were measured in enzymatically dissociated ventricular myocytes using the whole cell configuration of the patch clamp technique. ...

journal_title：Cardiovascular research

authors： Levesque PC,Hume JR

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:It has been suggested that nitric oxide (NO) is involved in the regulation of myocardial function in a variety of diseases such as dilated cardiomyopathy, myocarditis, heart transplant rejection, and septic shock. However, the underlying mechanism of NO mediated reduction of cardiac contractility has not been...

journal_title：Cardiovascular research

authors： Kelm M,Schäfer S,Dahmann R,Dolu B,Perings S,Decking UK,Schrader J,Strauer BE

更新日期：1997-11-01 00:00:00

abstract：AIMS:Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may h...

journal_title：Cardiovascular research

authors： Martorell J,Santomá P,Kolandaivelu K,Kolachalama VB,Melgar-Lesmes P,Molins JJ,Garcia L,Edelman ER,Balcells M

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H(2)O(2))-induced damage. METHODS:Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6 degrees grade, 5 days/week). Isolated perfused working hearts from ...

journal_title：Cardiovascular research

authors： Taylor RP,Ciccolo JT,Starnes JW

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...

journal_title：Cardiovascular research

authors： Li HF,Chen SA,Wu SN

更新日期：2000-03-01 00:00:00

abstract：AIMS:Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology of diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, the present study was designed to determine the mechanism by which HG initiates ...

journal_title：Cardiovascular research

authors： Wang F,Wang Y,Kim MS,Puthanveetil P,Ghosh S,Luciani DS,Johnson JD,Abrahani A,Rodrigues B

更新日期：2010-07-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) is a devastating condition for which no disease-modifying therapies exist. PH is recognized as proliferative disease of the pulmonary artery (PA). In the experimental newborn calf model of hypoxia-induced PH, adventitial fibroblasts in the PA wall exhibit a heightened replication index....

journal_title：Cardiovascular research

authors： Panzhinskiy E,Zawada WM,Stenmark KR,Das M

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that overproduction of endogenous nitric oxide (NO) during endotoxemia may modulate coronary autoregulation and myocardial reactive hyperemia. METHODS:Hearts of endotoxin-pretreated rats and controls were isolated and arranged for perfusion in a Langendorff preparation. Autor...

journal_title：Cardiovascular research

authors： Avontuur JA,Bruining HA,Ince C

更新日期：1997-08-01 00:00:00

abstract：AIM:Age and injury cause structural and functional changes in coronary artery smooth muscle cells (caSMCs) that influence the pathogenesis of coronary artery disease. Although paracrine signalling is widely believed to drive phenotypic changes in caSMCs, here we show that developmental origin within the fetal epicardiu...

journal_title：Cardiovascular research

authors： Wei K,Díaz-Trelles R,Liu Q,Diez-Cuñado M,Scimia MC,Cai W,Sawada J,Komatsu M,Boyle JJ,Zhou B,Ruiz-Lozano P,Mercola M

更新日期：2015-07-15 00:00:00

abstract：:Numerous epidemiological studies documented an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease. However, clinical interventions targeting HDL cholesterol failed to show clinical benefits with respect to cardiovascular risk reduction, sugge...

journal_title：Cardiovascular research

authors： Potì F,Simoni M,Nofer JR

更新日期：2014-08-01 00:00:00

abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

journal_title：Cardiovascular research

authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

更新日期：2012-12-01 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：:Cardiovascular diseases are among the main causes of morbidity and mortality in Western countries and considered as a leading public health issue. Therefore, there is a strong need for new disease models to support the development of novel therapeutics approaches. The successive improvement of genome editing tools wit...

journal_title：Cardiovascular research

authors： Vermersch E,Jouve C,Hulot JS

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The aims were (1) to investigate the effect of hypertention on left ventricular dilatation and haemodynamic alterations following acute myocardial infarction in spontaneously hypertensive rats (SHR) and normotensive rats (WKY); (2) to compare haemodynamic indices between the two groups; (3) to assess whether ...

journal_title：Cardiovascular research

authors： Nishikimi T,Yamagishi H,Takeuchi K,Takeda T

更新日期：1995-06-01 00:00:00