Developmental origin of age-related coronary artery disease.

abstract：:The effects of increasing oxygen tension from fetal to neonatal levels and of incubation in the cyclo-oxygenase inhibitor, indomethacin, on the response of isolated rings of neonatal rabbit ductus arteriosus and aorta to noradrenaline were studied in vitro. Increasing oxygen tension did not affect the sensitivity, as ...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1988-12-01 00:00:00

abstract：:Platelet-activating factor might be responsible for the alterations of diastolic function observed in different disease states and these potential effects have not been studied. The effect of incremental concentrations of platelet-activating factor (to a maximum of 200 nM) was therefore examined in isolated perfused r...

journal_title：Cardiovascular research

authors： Muñoz HR,Evans RD,Marsch SC,Foëx P

更新日期：1995-12-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands have been shown to ameliorate a variety of inflammatory conditions. The present study tested the hypothesis that PPAR-gamma ligands reduce experimental autoimmune myocarditis (EAM) associated with inhibition of the expansion and activation...

journal_title：Cardiovascular research

authors： Yuan Z,Liu Y,Liu Y,Zhang J,Kishimoto C,Wang Y,Ma A,Liu Z

更新日期：2003-09-01 00:00:00

abstract：:Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to transplantation would resu...

journal_title：Cardiovascular research

authors： Heng BC,Haider HKh,Sim EK,Cao T,Ng SC

更新日期：2004-04-01 00:00:00

abstract：:The heart responds to ischaemic stimuli with release of negative inotropic mediators such as cytokines, platelet-activating factor, oxygen free radicals, arachidonic acids, nitric oxide, adenosine, and still unidentified "cardiodepressant factors" that modulate myocardial performance via autocrine and paracrine coupli...

journal_title：Cardiovascular research

authors： Stangl V,Baumann G,Stangl K,Felix SB

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the changes in beta-adrenoceptor density (Bmax) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopa...

journal_title：Cardiovascular research

authors： van Veldhuisen DJ,Brodde OE,van Gilst WH,Schulze C,Hegeman H,Anthonio RL,Scholtens E,de Graeff PA,Wesseling H,Lie KI

更新日期：1995-09-01 00:00:00

abstract：AIMS:Caveolae are membrane microdomains where important signalling pathways are assembled and molecular effects transduced. In this study, we hypothesized that shear stress-mediated vasodilation (SSD) of mouse small coronary arteries (MCA) is caveolae-dependent. METHODS AND RESULTS:MCA (80-150 μm) isolated from wild-t...

journal_title：Cardiovascular research

authors： Chai Q,Wang XL,Zeldin DC,Lee HC

更新日期：2013-10-01 00:00:00

abstract：:Ultrasound has become a useful high resolution imaging modality for examining the cardiac microcirculation. With the use of microbubbles as an ultrasound contrast agent, ultrasound can be utilized to image the microcirculation and detect capillary flow abnormalities in acute ischaemia. A wide range of ultrasound frequ...

journal_title：Cardiovascular research

authors： Porter TR

更新日期：2009-09-01 00:00:00

abstract：AIMS:Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG on homocysteine (Hcy)-induced T-cell activation and potential signal pathways involved in atherosclerotic formation. METHODS AND RESULTS:The CD28...

journal_title：Cardiovascular research

authors： Ma K,Lv S,Liu B,Liu Z,Luo Y,Kong W,Xu Q,Feng J,Wang X

更新日期：2013-02-01 00:00:00

abstract：AIMS:TGF-β regulates tissue fibrosis: TGF-β promotes fibrosis, whereas bone morphogenetic protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after pressure overload is associated with disequilibrium in the signalling mediated by these cytokines, and (ii) BMP-7 exerts beneficial e...

journal_title：Cardiovascular research

authors： Merino D,Villar AV,García R,Tramullas M,Ruiz L,Ribas C,Cabezudo S,Nistal JF,Hurlé MA

更新日期：2016-06-01 00:00:00

abstract：:STUDY OBJECTIVE - The objective was to measure platelet function in vivo (as cutaneous bleeding time), the role of catecholamines, and the effect of inhibiting thromboxane synthesis on bleeding time, in patients with myocardial infarction, unstable angina, and non-cardiac chest pain. DESIGN - Haemotological variables ...

journal_title：Cardiovascular research

authors： Kristensen SD,Bath PM,Martin JF

更新日期：1990-01-01 00:00:00

abstract：AIMS:The molecular mechanisms controlling heart function and rhythmicity are incompletely understood. While it is widely accepted that the type 2 ryanodine receptor (Ryr2) is the major Ca(2+) release channel in excitation-contraction coupling, the role of these channels in setting a consistent beating rate remains cont...

journal_title：Cardiovascular research

authors： Bround MJ,Asghari P,Wambolt RB,Bohunek L,Smits C,Philit M,Kieffer TJ,Lakatta EG,Boheler KR,Moore ED,Allard MF,Johnson JD

更新日期：2012-12-01 00:00:00

abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...

journal_title：Cardiovascular research

authors： Burris JF,Waeber B,Brunner HR

更新日期：1985-12-01 00:00:00

abstract：AIMS:Human C-peptide has a beneficial effect on the prevention of diabetic neuropathy, nephropathy, and vascular complications; however, its role in protection against increased vascular permeability in diabetes remains unclear. Our purpose was to explore the potential protective role of C-peptide against microvascular...

journal_title：Cardiovascular research

authors： Lim YC,Bhatt MP,Kwon MH,Park D,Lee S,Choe J,Hwang J,Kim YM,Ha KS

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). METHODS:Dogs were paced for 3 weeks at 240 BPM to induce heart failure which was confirmed with hemodynamic and echocardiographic measurements. The pacemaker was turned off 30 min prior to the ischemia study. Normal...

journal_title：Cardiovascular research

authors： Hoskins DE,Ignasiak DP,Saganek LJ,Gallagher KP,Peterson JT

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：:The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine...

journal_title：Cardiovascular research

authors： Ishizuka T

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:Lower limb perfusion following arterial occlusion depends on the recruitment of collateral vessels. Blood flow through these collateral vessels may be jeopardized by hypersensitivity to vasoconstriction by serotonin (5-HT), as has been reported during hyperlipidemia and diabetes. Therefore the aim of this stu...

journal_title：Cardiovascular research

authors： Janiak P,Lainée P,Grataloup Y,Luyt CE,Bidouard JP,Michel JB,O'Connor SE,Herbert JM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：:Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (MPTP). This transition causes mitochondria to become uncoupled and capable of hydrolysing rather than synthesising ATP. Unrestrai...

journal_title：Cardiovascular research

authors： Halestrap AP,Clarke SJ,Javadov SA

更新日期：2004-02-15 00:00:00

abstract：OBJECTIVES:The A10 cell line was derived from the thoracic aorta of embryonic rat and is a commonly used model of vascular smooth muscle cells (VSMC). Despite its wide use this cell line has not been well characterized. This is especially important in light of recent evidence of phenotypically distinct cell populations...

journal_title：Cardiovascular research

authors： Rao RS,Miano JM,Olson EN,Seidel CL

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:We have attempted to demonstrate the induction of inducible nitric oxide synthase in human vascular tissue and define the capacity of different cytokines to induce this enzyme. METHODS:Segments of human arteries were stimulated with lipopolysaccharide (10 micrograms/ml), interleukin-1 beta (5 U/ml), tumor ne...

journal_title：Cardiovascular research

authors： Chester AH,Borland JA,Buttery LD,Mitchell JA,Cunningham DA,Hafizi S,Hoare GS,Springall DR,Polak JM,Yacoub MH

更新日期：1998-06-01 00:00:00

abstract：AIMS:Percutaneous implantation has already been used clinically and is a great option for treating young patients. The use of autologous tissue-engineered valved stents might solve the problem of degeneration and limited durability of biological heart valves. METHODS AND RESULTS:Porcine pulmonary heart valves and smal...

journal_title：Cardiovascular research

authors： Metzner A,Stock UA,Iino K,Fischer G,Huemme T,Boldt J,Braesen JH,Bein B,Renner J,Cremer J,Lutter G

更新日期：2010-12-01 00:00:00

abstract：AIMS:Adrenomedullin (AM) is a multifunctional peptide hormone that plays a significant role in vasodilation and angiogenesis. Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedem...

journal_title：Cardiovascular research

authors： Jin D,Harada K,Ohnishi S,Yamahara K,Kangawa K,Nagaya N

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism. METHODS:Small intrapulmonary arteries (IPA) from rats were mounted on a myograph and PGF2alpha (3 microM)-induced tension recorded before and 40...

journal_title：Cardiovascular research

authors： Vanková M,Snetkov VA,Knock GA,Aaronson PI,Ward JP

更新日期：2005-02-01 00:00:00

abstract：AIMS:Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology of diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, the present study was designed to determine the mechanism by which HG initiates ...

journal_title：Cardiovascular research

authors： Wang F,Wang Y,Kim MS,Puthanveetil P,Ghosh S,Luciani DS,Johnson JD,Abrahani A,Rodrigues B

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis, like the sympathetic nervous system and the renin-angiotensin-aldosterone (RAA) system, sustains life in stressful situations by increasing vascular tone and ensuring fuel availability. It also modulates inflammation and tissue repair processes. Untoward cardiovascular ef...

journal_title：Cardiovascular research

authors： Girod JP,Brotman DJ

更新日期：2004-11-01 00:00:00