Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition.

abstract：AIMS:Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcriptional regulators. PPARdelta has an established role in metabolism, wound healing, and angiogenesis. However, little is known about its function in endothelial homeostasis. We investigat...

journal_title：Cardiovascular research

authors： Ali F,Ali NS,Bauer A,Boyle JJ,Hamdulay SS,Haskard DO,Randi AM,Mason JC

更新日期：2010-03-01 00:00:00

abstract：:Eighty-one consecutive patients representing a wide clinical spectrum were studied to assess the degree of limitation of the atrial extrastimulus technique for measurement of atrioventricular node refractoriness; and, to determine the relationship between conductivity and functional refractoriness of the atrioventricu...

journal_title：Cardiovascular research

authors： Wyse DG

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:Angiotensin II stimulates vascular smooth muscle cell (VSMC) growth, and is considered to be an important mediator of intimal thickening after vascular injury. Recent evidence has indicated that VSMC apoptosis plays a major role in the response to balloon injury, and we therefore examined the effect of angiot...

journal_title：Cardiovascular research

authors： Holm AM,Andersen CB,Haunsø S,Hansen PR

更新日期：2000-02-01 00:00:00

abstract：:Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery...

journal_title：Cardiovascular research

authors： Singal PK,Khaper N,Palace V,Kumar D

更新日期：1998-12-01 00:00:00

abstract：STUDY OBJECTIVE:Protective effects of nipradilol, a newly synthesised vasodilating beta adrenoceptor antagonist, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine were determined by coronary arteriography and compared in vivo in pigs. DESIGN:Acetylc...

journal_title：Cardiovascular research

authors： Kawamura A,Fujiwara H,Ishida M,Takemura G,Kida M,Uegaito T,Tanaka M,Kawai C

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

journal_title：Cardiovascular research

authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Anthracyclines cause apoptotic death in many cell types through activation of the ceramide pathway. We tested the hypothesis that doxorubicin induces cardiac myocyte apoptosis through ceramide generation. METHODS:Adult rat ventricular myocytes were grown in the presence of 10% fetal calf serum, and exposed ...

journal_title：Cardiovascular research

authors： Delpy E,Hatem SN,Andrieu N,de Vaumas C,Henaff M,Rücker-Martin C,Jaffrézou JP,Laurent G,Levade T,Mercadier JJ

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. The aim of the present study was to relate preoperative serum lipids to endothelium-dependent relaxation in internal mammary arteries of patients underg...

journal_title：Cardiovascular research

authors： Voors AA,Oosterga M,Buikema H,May JF,Grandjean JG,van Buiten A,van Gilst WH

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of nicaraven in reducing myocardial as well as coronary endothelial preservation-reperfusion (P/R) injury. METHODS:In experiment I, isolated rat hearts were mounted on a Langendorff (L) apparatus to estimate the baseline cardiac function. Group 1, 8- and 12-h storage in histidine...

journal_title：Cardiovascular research

authors： Alam MS,Ku K,Hashimoto M,Nosaka S,Saitoh Y,Yamauchi M,Masumura S,Nakayama K,Tamura K

更新日期：1997-03-01 00:00:00

abstract：AIMS:Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and at...

journal_title：Cardiovascular research

authors： Katare R,Oikawa A,Cesselli D,Beltrami AP,Avolio E,Muthukrishnan D,Munasinghe PE,Angelini G,Emanueli C,Madeddu P

更新日期：2013-01-01 00:00:00

abstract：:The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action potentials were studied for nine Class I anti-arrhythmic drugs using standard microelectrode techniques. The drugs were found to fall into three well-demarcated subgroups with "fast" (lignocaine...

journal_title：Cardiovascular research

authors： Campbell TJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:While natriuretic peptides can inhibit growth of vascular muscle cells (VSMC), controversy exists as to whether this effect is mediated via the guanylate cyclase-coupled receptors, NPR-A and NPR-B, or the clearance receptor, NPR-C. The original aim of this study was to examine the mechanism by which the NPR-C...

journal_title：Cardiovascular research

authors： Hutchinson HG,Trindade PT,Cunanan DB,Wu CF,Pratt RE

更新日期：1997-07-01 00:00:00

abstract：:Because of ventricular interdependence, part of the measured left ventricular diastolic pressure can be attributed to the right ventricle. Therefore, we examined the hypothesis that left ventricular diastolic properties are modified by alterations in right ventricular compliance and pressure even without a change in r...

journal_title：Cardiovascular research

authors： Santamore WP,Constantinescu M,Vinten-Johansen J,Johnston WE,Little WC

更新日期：1988-11-01 00:00:00

abstract：:Injudicious selection of a saphenous vein graft can adversely affect the the late postoperative patency of the proximal coronary artery which it bypasses. The purpose of this investigation was to deduce an upper bound for graft diameter, at small angle of distal anastomosis, below which the stenosed artery will remain...

journal_title：Cardiovascular research

authors： Moskowitz SE,Lewis BS,Milo S,Amar R

更新日期：1979-07-01 00:00:00

abstract：OBJECTIVE:Nitric oxide (NO) has been shown to induce apoptosis in cardiomyocytes under normoxic conditions. The ability of NO to induce apoptosis after ischemia-reperfusion, a situation of increased NO release in vivo, has not been investigated. The present study was undertaken to characterize the pathway of induction ...

journal_title：Cardiovascular research

authors： Taimor G,Hofstaetter B,Piper HM

更新日期：2000-02-01 00:00:00

abstract：AIMS:Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable fo...

journal_title：Cardiovascular research

authors： Bucci M,Vellecco V,Cantalupo A,Brancaleone V,Zhou Z,Evangelista S,Calderone V,Papapetropoulos A,Cirino G

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The aim of this work was to compare the effects of supplementation of rat chow diet with potassium (K+) and whey mineral concentrate (Whey), a diet rich in milk minerals, on blood pressure and arterial responses in vitro in spontaneously hypertensive rats (SHR). METHODS:Thirty young SHR and twenty Wistar-Kyo...

journal_title：Cardiovascular research

authors： Wu X,Tolvanen JP,Hutri-Kähönen N,Kähönen M,Mäkynen H,Korpela R,Ruskoaho H,Karjala K,Pörsti I

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Adenosine inhibits neutrophil adhesion and injury to isolated cardiac myocytes. In the present study, the contribution of selectin and CD18 interactions to neutrophil-myocyte adhesion and their sensitivity to adenosine were assessed. METHODS:Activated human neutrophils and canine myocytes were incubated with...

journal_title：Cardiovascular research

authors： Bullough DA,Magill MJ,Mullane KM,Firestein GS

更新日期：1996-08-01 00:00:00

abstract：AIMS:Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR). RyR type 1 or type 2 was prepared from rabbit skeletal muscle or pig cardiac muscle, respectively. In heart failure,...

journal_title：Cardiovascular research

authors： Blayney LM,Jones JL,Griffiths J,Lai FA

更新日期：2010-01-01 00:00:00

abstract：:Mayer waves are oscillations of arterial pressure occurring spontaneously in conscious subjects at a frequency lower than respiration (approximately 0.1 Hz in humans). Mayer waves are tightly coupled with synchronous oscillations of efferent sympathetic nervous activity and are almost invariably enhanced during states...

journal_title：Cardiovascular research

authors： Julien C

更新日期：2006-04-01 00:00:00

abstract：:The cardiac mechano- and chemoreceptors are broadly distributed in the myocardium and coronary vessels. A portion of these receptors extends over the epicardium and pericardium and therefore can be excited by mechanical or chemical stimuli directly applied to the surface of the heart. Excitation of epicardial receptor...

journal_title：Cardiovascular research

authors： Cinca J,Rodríguez-Sinovas A

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:While it is probable that the cerebrovascular spasm which occurs after subarachnoid haemorrhage results from the action of haemoglobin, the mechanism of that process remains unclear. These studies were thus designed to test the hypothesis that the action of oxyhaemoglobin results from the iron-catalyzed form...

journal_title：Cardiovascular research

authors： Vollrath B,Chan P,Findlay M,Cook D

更新日期：1995-10-01 00:00:00

abstract：:The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and funct...

journal_title：Cardiovascular research

authors： Penela P,Murga C,Ribas C,Tutor AS,Peregrín S,Mayor F Jr

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Hemodynamic stresses are considered to be important regulators of gene expression in vascular cells. In this study, we have investigated the role of shear stress on ACE expression in cultured rat vascular cells, and focused on the regulation of ACE expression in smooth muscle cells. METHODS:Rat aortic endoth...

journal_title：Cardiovascular research

authors： Gosgnach W,Challah M,Coulet F,Michel JB,Battle T

更新日期：2000-01-14 00:00:00

abstract：AIMS:Vascular endothelial growth factors (VEGFs) and their receptors (VEGF-Rs) are among the most powerful factors regulating vascular growth. However, it has remained unknown whether stimulation of VEGF-R1, VEGF-R2 or both of the receptors produces the best angiogenic responses in myocardium. The aim of this study was...

journal_title：Cardiovascular research

authors： Huusko J,Merentie M,Dijkstra MH,Ryhänen MM,Karvinen H,Rissanen TT,Vanwildemeersch M,Hedman M,Lipponen J,Heinonen SE,Eriksson U,Shibuya M,Ylä-Herttuala S

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

journal_title：Cardiovascular research

authors： Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Chlamydia pneumoniae infection has been associated with atherosclerosis, although the mechanisms by which C. pneumoniae contribute to atherogenesis remain unclear. Altered production of nitric oxide, a known bactericidal and anti-inflammatory agent, represents one possible mechanistic link. To examine this is...

journal_title：Cardiovascular research

authors： Chesebro BB,Blessing E,Kuo CC,Rosenfeld ME,Puolakkainen M,Campbell LA

更新日期：2003-10-15 00:00:00

abstract：AIMS:Cardiac β-adrenergic receptors (β-AR) are key regulators of cardiac haemodynamics and size. The scaffolding protein A-kinase anchoring protein 79/150 (AKAP5) is a key regulator of myocardial signalling by β-ARs. We examined the function of AKAP5 in regulating cardiac haemodynamics and size, and the role of β-ARs a...

journal_title：Cardiovascular research

authors： Li X,Matta SM,Sullivan RD,Bahouth SW

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. METHODS:To test whether endogenous catecholamines are involved in preconditio...

journal_title：Cardiovascular research

authors： Weselcouch EO,Baird AJ,Sleph PG,Dzwonczyk S,Murray HN,Grover GJ

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the roles of left atrial pressure and ventricular function in the determination of early diastolic filling. METHODS:Various grades of ventricular dysfunction were made in 12 mongrel dogs by coronary microembolization under pentobarbitone anaesthesia. Left atrial pressure was altered by...

journal_title：Cardiovascular research

authors： Nakatani S,Beppu S,Miyatake K,Nimura Y

更新日期：1992-02-01 00:00:00