Vascular NADPH oxidases: molecular mechanisms of activation.

abstract：:Supravalvar aortic banding was performed in 6 to 12 week puppies. Sixteen animals were studied 7.3 (3.5 to 10) months later, closed-chested under morphine-chloralose, catheters being positioned in the great vessels and heart, including the left atrium for microsphere injection. Compared with 11 controls, eight dogs de...

journal_title：Cardiovascular research

authors： Einzig S,Leonard JJ,Tripp MR,Lucas RV,Swayze CR,Fox IJ

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVE:We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecular mechanism for and the phosphorylation sites for the enhanced MLC pho...

journal_title：Cardiovascular research

authors： Shimokawa H,Seto M,Katsumata N,Amano M,Kozai T,Yamawaki T,Kuwata K,Kandabashi T,Egashira K,Ikegaki I,Asano T,Kaibuchi K,Takeshita A

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. METHO...

journal_title：Cardiovascular research

authors： Pires NM,Schepers A,van der Hoeven BL,de Vries MR,Boesten LS,Jukema JW,Quax PH

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:Myocardial ischemia results in an early phase of arrhythmias that primarily involves reentrant mechanisms. However, the trigger that initiates reentry remains unknown. We studied the initiation of reentry attending the development of electrical heterogeneity during simulated ischemia in isolated canine right...

journal_title：Cardiovascular research

authors： Lukas A,Antzelevitch C

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogeno...

journal_title：Cardiovascular research

authors： Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DM

更新日期：1980-02-01 00:00:00

abstract：:Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent...

journal_title：Cardiovascular research

authors： Spadaccio C,Antoniades C,Nenna A,Chung C,Will R,Chello M,Gaudino MFL

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The functional status of heart failure (HF) is conventionally evaluated by peak exercise oxygen consumption (VO2 max). Dobutamine echocardiography can be used to evaluate myocardial reserve. The aim of this study was to estimate the functional status of chronic HF in patients with dilated cardiomyopathy, by ...

journal_title：Cardiovascular research

authors： Paraskevaidis IA,Tsiapras DP,Adamopoulos S,Kremastinos DT

更新日期：1999-07-01 00:00:00

abstract：:It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac C...

journal_title：Cardiovascular research

authors： Gros D,Dupays L,Alcoléa S,Meysen S,Miquerol L,Théveniau-Ruissy M

更新日期：2004-05-01 00:00:00

abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...

journal_title：Cardiovascular research

authors： Tanabe M,Fujiwara S,Ohta N,Shimamoto N,Hirata M

更新日期：1980-05-01 00:00:00

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a major risk factor for cardio-embolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern. This study sought to identify new targets to develop safer antithrombotic therapie...

journal_title：Cardiovascular research

authors： Allende M,Molina E,Guruceaga E,Tamayo I,González-Porras JR,Gonzalez-López TJ,Toledo E,Rabal O,Ugarte A,Roldán V,Rivera J,Oyarzabal J,Montes R,Hermida J

更新日期：2016-06-01 00:00:00

abstract：:The intrinsic ability of resistance arteries to respond to transmural pressure is the single most important determinant of their function. Despite an ever-growing catalogue of signalling pathways that underlie the myogenic response, it remains an enigmatic mechanism. The myogenic response's mechanistic diversity has l...

journal_title：Cardiovascular research

authors： Lidington D,Schubert R,Bolz SS

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive he...

journal_title：Cardiovascular research

authors： Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JM

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that overproduction of endogenous nitric oxide (NO) during endotoxemia may modulate coronary autoregulation and myocardial reactive hyperemia. METHODS:Hearts of endotoxin-pretreated rats and controls were isolated and arranged for perfusion in a Langendorff preparation. Autor...

journal_title：Cardiovascular research

authors： Avontuur JA,Bruining HA,Ince C

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...

journal_title：Cardiovascular research

authors： Doubell AF,Lazure C,Charbonneau C,Thibault G

更新日期：1993-07-01 00:00:00

abstract：:Since the discovery of atrial natriuretic peptide (ANP) more than 20 years ago, numerous studies have focused on the mechanisms regulating ANP secretion. From a physiological standpoint, the most important factor governing ANP secretion is mechanical stretching of the atria, which normally occurs when extracellular fl...

journal_title：Cardiovascular research

authors： Dietz JR

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of the Na, K pump current (I(p)) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate whether I(p) contributes to the changes in APD and ERP associated with chronic atrial fibrillation (AF). METHODS:Action potentials...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Cytokine induction of intercellular adhesion molecule-1 (ICAM-1) on cardiac myocytes may be a critical step in cardiac inflammation associated with acute myocardial infarction and myocarditis. The aim of this study was to investigate the involvement of monocyte chemoattractant protein-1 (MCP-1), a homologue o...

journal_title：Cardiovascular research

authors： Ban K,Ikeda U,Takahashi M,Kanbe T,Kasahara T,Shimada K

更新日期：1994-08-01 00:00:00

abstract：:Sudden cardiac death, which is mainly associated with the presence of life-threatening ventricular arrhythmias, is a common 'killer' among patients with coronary artery disease. Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiov...

journal_title：Cardiovascular research

authors： Kostapanos MS,Liberopoulos EN,Goudevenos JA,Mikhailidis DP,Elisaf MS

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The potential use of bone marrow stromal cells (MSCs) as a cellular therapy for chronic cardiac diseases relies on the ability of the cell to replicate extensively in vitro and to give rise to myogenic cells that can replace the damaged cardiomyocytes. For this reason the present study investigated the replic...

journal_title：Cardiovascular research

authors： Liu Y,Song J,Liu W,Wan Y,Chen X,Hu C

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:It has been shown that cGMP content is reduced in post-ischemic myocardium, and that stimulation of cGMP synthesis prevents cardiomyocyte hypercontracture and cell death in vitro. This study was aimed at determining whether administration of the natriuretic peptide urodilatin (URO) at the time of reperfusion ...

journal_title：Cardiovascular research

authors： Padilla F,Garcia-Dorado D,Agulló L,Barrabés JA,Inserte J,Escalona N,Meyer M,Mirabet M,Pina P,Soler-Soler J

更新日期：2001-08-15 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-)). METHODS:Nineteen adult annexin A7(-/-) and 14 wild-type m...

journal_title：Cardiovascular research

authors： Schrickel JW,Brixius K,Herr C,Clemen CS,Sasse P,Reetz K,Grohé C,Meyer R,Tiemann K,Schröder R,Bloch W,Nickenig G,Fleischmann BK,Noegel AA,Schwinger RH,Lewalter T

更新日期：2007-11-01 00:00:00

abstract：AIMS:Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR ...

journal_title：Cardiovascular research

authors： Ma KL,Liu J,Wang CX,Ni J,Zhang Y,Wu Y,Lv LL,Ruan XZ,Liu BC

更新日期：2013-12-01 00:00:00

abstract：AIMS:Imbalance between pro- and antioxidant species (e.g. during aging) plays a crucial role for vascular function and is associated with oxidative gene regulation and modification. Vascular aging is associated with progressive deterioration of vascular homeostasis leading to reduced relaxation, hypertrophy, and a high...

journal_title：Cardiovascular research

authors： Wenzel P,Schuhmacher S,Kienhöfer J,Müller J,Hortmann M,Oelze M,Schulz E,Treiber N,Kawamoto T,Scharffetter-Kochanek K,Münzel T,Bürkle A,Bachschmid MM,Daiber A

更新日期：2008-11-01 00:00:00

abstract：:Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the...

journal_title：Cardiovascular research

authors： Harvey EJ,Ramji DP

更新日期：2005-07-01 00:00:00

abstract：AIMS:SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage. METHODS AND ...

journal_title：Cardiovascular research

authors： Galle-Treger L,Moreau M,Ballaire R,Poupel L,Huby T,Sasso E,Troise F,Poti F,Lesnik P,Le Goff W,Gautier EL,Huby T

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:This study was conducted to evaluate to what extent the ischemia-reperfusion injury resulting from the cardiopulmonary bypass (CPB) and aortic cross-clamping procedures during coronary artery bypass grafting (CABG) contributes to the systemic inflammatory response generally found in these patients. METHODS:S...

journal_title：Cardiovascular research

authors： Fransen EJ,Maessen JG,Hermens WT,Glatz JF,Buurman WA

更新日期：2000-03-01 00:00:00

abstract：:Atherosclerosis is considered a to be multifactorial disease driven by inflammatory reactions. The process of inflammation also contributes to the pathogenesis of acute atherothrombotic events. C-reactive protein (CRP) is an acute phase protein and its concentration in serum reflects the inflammatory condition of the ...

journal_title：Cardiovascular research

authors： Paffen E,DeMaat MP

更新日期：2006-07-01 00:00:00