Do statins have an antiarrhythmic activity?

abstract：OBJECTIVE:The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the anaesthetised dog. METHODS:Heparin or N-acetylheparin was given in three repeated intravenous doses of 2 mg.kg-1. Drug or...

journal_title：Cardiovascular research

authors： Black SC,Gralinski MR,Friedrichs GS,Kilgore KS,Driscoll EM,Lucchesi BR

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Polymorphic ventricular tachycardias (PVT) occur spontaneously in canine hearts under the combination of D-sotalol (S), bradycardia and phenylephrine (PE). We investigated the hypotheses that: (1) the activation patterns of the initial PVT beats would be consistent with an origin in the ventricular conduction...

journal_title：Cardiovascular research

authors： Derakhchan K,Cardinal R,Brunet S,Klug D,Pharand C,Kuś T,Sasyniuk BI

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Previous studies showed that treatment of hearts with nisoldipine improves recovery of cardiac function following ischaemia, improves reperfusion, and reduces the constrictor sensitivity to endothelin. The aim of the present study was to assess the reduction in vasodilator responses that occurs following isch...

journal_title：Cardiovascular research

authors： Yaghi MM,Watts JA

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that nitric oxide (or a related compound) contributes to the coronary vasodilatation during physiological increases of myocardial O2 consumption that occur with exercise. METHODS:Active hyperaemia associated with graded treadmill exercise and coronary reactive hyperaemia we...

journal_title：Cardiovascular research

authors： Altman JD,Kinn J,Duncker DJ,Bache RJ

更新日期：1994-01-01 00:00:00

abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...

journal_title：Cardiovascular research

authors： Burris JF,Waeber B,Brunner HR

更新日期：1985-12-01 00:00:00

abstract：:As the developing heart grows and the chamber walls thicken, passive diffusion of oxygen and nutrients is replaced by a vascular plexus which remodels and expands to form a mature coronary vascular system. The coronary arteries and veins ensure the continued development of the heart and facilitate cardiac output with ...

journal_title：Cardiovascular research

authors： Riley PR,Smart N

更新日期：2011-07-15 00:00:00

abstract：AIMS:Hypercholesterolaemia and myeloperoxidase (MPO) overexpression are two well-recognized risk factors for ischaemic heart disease. Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists have recently been shown to reduce ischaemic heart injury in hypercholesterolaemic animals. However, whether PPARgam...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Qu Y,Lau WB,Lopez BL,Christopher TA,Koch W,Yue TL,Ma XL

更新日期：2009-02-01 00:00:00

abstract：:This paper puts emphasis on pioneers who developed cardiac flow dynamics concepts during the second half of the 20th century at a period where pressure measurements were the rule. Thinking flow instead of pressure dynamics corresponded to in-depth conceptual changes: whereas blood pressure generally has a single posit...

journal_title：Cardiovascular research

authors： Veyrat C

更新日期：2001-08-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：:A growing body of animal studies provides evidence for potential cardioprotective effects of inhibitors of the enzyme phosphodiesterase isoform 5. Infarct size reduction by administration of phosphodiesterase 5 inhibitors was described in various experimental models of ischaemia and reperfusion. Furthermore, potential...

journal_title：Cardiovascular research

authors： Reffelmann T,Kloner RA

更新日期：2009-07-15 00:00:00

abstract：Aims:Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors associated with atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 microRNAs (miRNAs) controlling inflammatory, immu...

journal_title：Cardiovascular research

authors： D'Amore S,Härdfeldt J,Cariello M,Graziano G,Copetti M,Di Tullio G,Piglionica M,Scialpi N,Sabbà C,Palasciano G,Vacca M,Moschetta A

更新日期：2018-07-01 00:00:00

abstract：ABSTRACT:Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an overwhelming host response to infection resulting in organ failure. The endothelium is an active contributor to sepsis and as such represents a major target for therapy. During sepsis, endothelial cells amplify the immune response...

journal_title：Cardiovascular research

authors： Dolmatova EV,Wang K,Mandavilli R,Griendling KK

更新日期：2021-01-01 00:00:00

abstract：AIMS:Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant, CnAβ1, has beneficial effects on the infarcted heart. However, whet...

journal_title：Cardiovascular research

authors： López-Olañeta MM,Villalba M,Gómez-Salinero JM,Jiménez-Borreguero LJ,Breckenridge R,Ortiz-Sánchez P,García-Pavía P,Ibáñez B,Lara-Pezzi E

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Caffeic acid phenethyl ester (CAPE), which is derived from the propolis of honeybee hives, has been demonstrated to possess multiple pharmacological activities. In the present study, CAPE (6-25 microM) specifically inhibited collagen-induced platelet aggregation and the ATP release reaction in platelet suspen...

journal_title：Cardiovascular research

authors： Hsiao G,Lee JJ,Lin KH,Shen CH,Fong TH,Chou DS,Sheu JR

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...

journal_title：Cardiovascular research

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Nadeau R

更新日期：1992-10-01 00:00:00

abstract：:Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respe...

journal_title：Cardiovascular research

authors： Farrar DJ,Green HD,Peterson DW

更新日期：1979-01-01 00:00:00

abstract：AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II...

journal_title：Cardiovascular research

authors： Cooper HA,Cicalese S,Preston KJ,Kawai T,Okuno K,Choi ET,Kasahara S,Uchida HA,Otaka N,Scalia R,Rizzo V,Eguchi S

更新日期：2020-05-08 00:00:00

abstract：OBJECTIVE:Recently, we have found that rat CMV (RCMV) infected smooth muscle cells (SMCs) in rat carotid arteries when administered 14 days after balloon injury. In the present study we investigated (1) the long term effects of CMV infection on neointimal cross-sectional area, and (2) whether the phenotype of the intim...

journal_title：Cardiovascular research

authors： Persoons MC,Daemen MJ,van Kleef EM,Grauls GE,Wijers E,Bruggeman CA

更新日期：1997-11-01 00:00:00

abstract：:The genetic basis of cardiac electrical phenotypes has in the last 25 years been the subject of intense investigation. While in the first years, such efforts were dominated by the study of familial arrhythmia syndromes, in recent years, large consortia of investigators have successfully pursued genome-wide association...

journal_title：Cardiovascular research

authors： Glinge C,Lahrouchi N,Jabbari R,Tfelt-Hansen J,Bezzina CR

更新日期：2020-07-15 00:00:00

abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

journal_title：Cardiovascular research

authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:A previous study from this laboratory showed that elevation of endogenous angiotensin II (Ang II) and upregulation of the angiotensin II type 1 (AT(1)) receptor in the carotid body (CB) are involved in the enhanced peripheral chemoreceptor sensitivity in rabbits with chronic heart failure (CHF). NADPH oxidase...

journal_title：Cardiovascular research

authors： Li YL,Gao L,Zucker IH,Schultz HD

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：:The structural nature of fibrillar collagen involved in the replacement fibrosis which accompanies discrete areas of cell necrosis remains uncertain, as does its influence on the diastolic and systolic stiffness of the intact myocardium. This study, using 15 micron diameter microsphere embolisation of the rat myocardi...

journal_title：Cardiovascular research

authors： Carroll EP,Janicki JS,Pick R,Weber KT

更新日期：1989-08-01 00:00:00

abstract：:Netrins are a family of laminin-like proteins, which were initially identified for their role in embryonic axonal guidance. Over recent years, it has become apparent that netrin-1 may additionally be involved in the underlying pathology of several multisystem diseases, making it an attractive potential therapeutic tar...

journal_title：Cardiovascular research

authors： Layne K,Ferro A,Passacquale G

更新日期：2015-09-01 00:00:00

abstract：AIMS:Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other i...

journal_title：Cardiovascular research

authors： Mezzano V,Liang Y,Wright AT,Lyon RC,Pfeiffer E,Song MY,Gu Y,Dalton ND,Scheinman M,Peterson KL,Evans SM,Fowler S,Cerrone M,McCulloch AD,Sheikh F

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The aim was to test for the presence of cAMPi activated and ATPo activated chloride conductances (ICl(cAMP) and ICl(ATP)) in mouse ventricular myocytes. METHODS:Membrane currents were measured in enzymatically dissociated ventricular myocytes using the whole cell configuration of the patch clamp technique. ...

journal_title：Cardiovascular research

authors： Levesque PC,Hume JR

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...

journal_title：Cardiovascular research

authors： Rekhter MD,O'Brien E,Shah N,Schwartz SM,Simpson JB,Gordon D

更新日期：1996-09-01 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：OBJECTIVE:The mechanosensitive nonselective cation channel (NSC(MS)) and endothelin-1 (ET-1) play critical roles in the regulation of vascular tone. This study was undertaken to investigate the effect of ET-1 on NSC(MS) and on the myogenic response of arteries. METHODS:Cell-attached patch-clamp techniques were applied...

journal_title：Cardiovascular research

authors： Lee HA,Baek EB,Park KS,Jung HJ,Kim JI,Kim SJ,Earm YE

更新日期：2007-11-01 00:00:00