Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation.

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00

abstract：AIMS:Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrh...

journal_title：Cardiovascular research

authors： Manotheepan R,Danielsen TK,Sadredini M,Anderson ME,Carlson CR,Lehnart SE,Sjaastad I,Stokke MK

更新日期：2016-08-01 00:00:00

abstract：AIMS:A cytosolic calcium (Ca(2+)(i)) increase is an important activation signal for the endothelium. We investigated whether interendothelial spreading of the Ca(2+) signal via gap junctions (GJs) plays a role for the overall Ca(2+)(i) increase in response to vasoactive agonists. METHODS AND RESULTS:In human umbilical...

journal_title：Cardiovascular research

authors： Kameritsch P,Pogoda K,Ritter A,Münzing S,Pohl U

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：:One of the striking differences that distinguish the adult from the embryonic heart in mammals and set it apart from the heart in urodeles and teleosts is the incapacity of cardiomyocytes to respond to damage by proliferation. While the molecular reasons underlying these characteristics still await elucidation, mounti...

journal_title：Cardiovascular research

authors： Zacchigna S,Giacca M

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. METHODS:In situ hybridizations with Cx40 and ...

journal_title：Cardiovascular research

authors： Van Kempen MJ,Vermeulen JL,Moorman AF,Gros D,Paul DL,Lamers WH

更新日期：1996-11-01 00:00:00

abstract：AIMS:To compare the prevalence of electrocardiogram (ECG)-documented atrial fibrillation (or flutter) (AF) across eight regions of the world, and to examine anti-thrombotic use and clinical outcomes. METHODS AND RESULTS:Baseline ECGs were collected in 153,152 middle-aged participants (ages 35 to 70 years) to document ...

journal_title：Cardiovascular research

authors： Joseph PG,Healey JS,Raina P,Connolly SJ,Ibrahim Q,Gupta R,Avezum A,Dans AL,Lopez-Jaramillo P,Yeates K,Teo K,Douma R,Bohonar A,Chifamba J,Lanas F,Dagenais GR,Lear SA,Kumar R,Kengne AP,Keskinler M,Mohan V,Mony P,

更新日期：2020-08-10 00:00:00

abstract：AIMS:Both mitochondria and nitric oxide (NO*) contribute to cardioprotection by ischaemic preconditioning (IPC). IPC causes mild uncoupling of mitochondria via uncoupling proteins (UCPs) and the adenine nucleotide translocase (ANT), and mild uncoupling per se is cardioprotective. Although electrophilic lipids are known...

journal_title：Cardiovascular research

authors： Nadtochiy SM,Baker PR,Freeman BA,Brookes PS

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

journal_title：Cardiovascular research

authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：AIMS:Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein phosphorylation, but the underlying mechanisms remain unclear. This is due to a lack of investigation into the local, rather than global, regulation of PP...

journal_title：Cardiovascular research

authors： Chiang DY,Li N,Wang Q,Alsina KM,Quick AP,Reynolds JO,Wang G,Skapura D,Voigt N,Dobrev D,Wehrens XH

更新日期：2014-07-01 00:00:00

abstract：AIMS:Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcriptional regulators. PPARdelta has an established role in metabolism, wound healing, and angiogenesis. However, little is known about its function in endothelial homeostasis. We investigat...

journal_title：Cardiovascular research

authors： Ali F,Ali NS,Bauer A,Boyle JJ,Hamdulay SS,Haskard DO,Randi AM,Mason JC

更新日期：2010-03-01 00:00:00

abstract：:We have studied the responses to a brief interruption of a train of steady state beats, namely: (1) a single prolonged depolarisation within the train; (2) a single short interval within the train; (3) a single long interval within the train. These responses are predicted by a two compartment model of intracellular ca...

journal_title：Cardiovascular research

authors： Noble MI,Arlock P,Gath J,Grainger N,Ravens U,Wohlfart B

更新日期：1993-10-01 00:00:00

abstract：AIMS:The P2Y12 antagonist ticagrelor reduces mortality in patients with acute coronary syndrome (ACS), compared with clopidogrel, and the mechanisms underlying this effect are not clearly understood. Arterial thrombosis is the key event in ACS; however, direct vascular effects of either ticagrelor or clopidogrel with f...

journal_title：Cardiovascular research

authors： Reiner MF,Akhmedov A,Stivala S,Keller S,Gaul DS,Bonetti NR,Savarese G,Glanzmann M,Zhu C,Ruf W,Yang Z,Matter CM,Lüscher TF,Camici GG,Beer JH

更新日期：2017-01-01 00:00:00

abstract：Aims:Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in m...

journal_title：Cardiovascular research

authors： Gaul DS,Weber J,van Tits LJ,Sluka S,Pasterk L,Reiner MF,Calatayud N,Lohmann C,Klingenberg R,Pahla J,Vdovenko D,Tanner FC,Camici GG,Eriksson U,Auwerx J,Mach F,Windecker S,Rodondi N,Lüscher TF,Winnik S,Matter CM

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...

journal_title：Cardiovascular research

authors： Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

更新日期：1996-04-01 00:00:00

abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

journal_title：Cardiovascular research

authors： Fishbein MC,Kulber D,Stancl M,Edwalds G

更新日期：1986-01-01 00:00:00

abstract：:Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respe...

journal_title：Cardiovascular research

authors： Farrar DJ,Green HD,Peterson DW

更新日期：1979-01-01 00:00:00

abstract：:Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent...

journal_title：Cardiovascular research

authors： Spadaccio C,Antoniades C,Nenna A,Chung C,Will R,Chello M,Gaudino MFL

更新日期：2020-03-01 00:00:00

abstract：:Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

journal_title：Cardiovascular research

authors： Zhu H,Fan GC

更新日期：2012-05-01 00:00:00

abstract：Aims:RHOA-ROCK signalling regulates cell migration, proliferation, differentiation, and transcription. RHOA is expressed in the developing cardiac conduction system in chicken and mice. In early development, the entire sinus venosus myocardium, including both the transient left-sided and the definitive sinoatrial node ...

journal_title：Cardiovascular research

authors： Vicente-Steijn R,Kelder TP,Tertoolen LG,Wisse LJ,Pijnappels DA,Poelmann RE,Schalij MJ,deRuiter MC,Gittenberger-de Groot AC,Jongbloed MRM

更新日期：2017-08-01 00:00:00

abstract：AIMS:A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling ...

journal_title：Cardiovascular research

authors： Rossitto G,Maiolino G,Lerco S,Ceolotto G,Blackburn G,Mary S,Antonelli G,Berton C,Bisogni V,Cesari M,Seccia TM,Lenzini L,Pinato A,Montezano A,Touyz RM,Petrie MC,Daly R,Welsh P,Plebani M,Rossi GP,Delles C

更新日期：2020-07-16 00:00:00

abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...

journal_title：Cardiovascular research

authors： Tanabe M,Fujiwara S,Ohta N,Shimamoto N,Hirata M

更新日期：1980-05-01 00:00:00

abstract：AIMS:Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, the cellular and molecular mechanisms of platelet-dependent angiogenesis, especially the involvement of TP signallin...

journal_title：Cardiovascular research

authors： Amano H,Ito Y,Eshima K,Kato S,Ogawa F,Hosono K,Oba K,Tamaki H,Sakagami H,Shibuya M,Narumiya S,Majima M

更新日期：2015-09-01 00:00:00

abstract：AIMS:Alterations in cardiac acid-base balance can produce profound impact on excitation-contraction coupling and precipitate cardiac dysfunction and arrhythmias. A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in...

journal_title：Cardiovascular research

authors： Kim HJ,Myers R,Sihn CR,Rafizadeh S,Zhang XD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that chronic cardiac denervation impairs myocardial glucose oxidation. To investigate this further we tested whether the tissue content of glucose transporters, activity of glycolytic enzymes or metabolic capacity of pyruvate dehydrogenase were altered. Moreover, we investigated wh...

journal_title：Cardiovascular research

authors： van der Vusse GJ,Dubelaar ML,Coumans WA,Seymour AM,Clarke SB,Bonen A,Drake-Holland AJ,Noble MI

更新日期：1998-01-01 00:00:00

abstract：AIMS:Placental growth factor (PlGF), a homologue of vascular endothelial growth factor, is a pleiotropic cytokine with a pro-inflammatory activity. Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an ant...

journal_title：Cardiovascular research

authors： Roncal C,Buysschaert I,Gerdes N,Georgiadou M,Ovchinnikova O,Fischer C,Stassen JM,Moons L,Collen D,De Bock K,Hansson GK,Carmeliet P

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

journal_title：Cardiovascular research

authors： Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

更新日期：2005-07-01 00:00:00

abstract：AIMS:We have demonstrated an important role of bone marrow-derived stem cells in preservation of myocardial function. We investigated whether Akt-1 of lin(-)c-kit(+) stem cells preserves ventricular function following myocardial infarction (MI). METHODS AND RESULTS:Isolated lin(-)c-kit(+) cells were conjugated with an...

journal_title：Cardiovascular research

authors： Tseng A,Stabila J,McGonnigal B,Yano N,Yang MJ,Tseng YT,Davol PA,Lum LG,Padbury JF,Zhao TC

更新日期：2010-09-01 00:00:00