Abstract:
:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blood pressure development in SHRs. The effect of treatment on heart weight and on mesenteric resistance vessels (i.d. ca 170 microns) characteristics was investigated. In a first study, two oral doses of felodipine were added to the diet of SHRs, in concentrations of either 0.5 or 1.5 mg X g-1 rat food. Both treatments lowered mean arterial pressure by about 19% (p less than 0.001). In a second study, the lower dose of felodipine (0.5 mg . g-1 rat food) was therefore used to treat both SHRs and WKYs. Treatment did not interfere with weight or food intake of either SHRs or WKYs but increased average weekly water intake significantly. In neither strain was the pulse rate or, surprisingly, heart/body weight ratio affected by treatment. Furthermore, mesenteric resistance vessel morphology and mechanics were not affected by the blood pressure reduction. The noradrenaline and calcium sensitivity of mesenteric resistance vessels from treated rats was greater (p less than 0.001) than those from control rats. These findings indicate that blood pressure reduction with felodipine does not affect cardiovascular structure in young SHRs.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Nyborg NC,Mulvany MJdoi
10.1093/cvr/19.9.528subject
Has Abstractpub_date
1985-09-01 00:00:00pages
528-36issue
9eissn
0008-6363issn
1755-3245journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:Automatic analysis of the frequency content of the fibrillatory baseline on the surface ECG accurately reflects the average rate of atrial fibrillation (AF). This frequency measurement correlates with the behavior of AF and predicts the response to administration of ibutilide, a new antiarrhythmic drug. Neith...
journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00156-x
更新日期:1999-10-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/cvs211
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更新日期:2007-07-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/9.3.336
更新日期:1975-05-01 00:00:00
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更新日期:1992-09-01 00:00:00
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更新日期:2020-07-15 00:00:00
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doi:10.1093/cvr/28.7.1049
更新日期:1994-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(00)00123-1
更新日期:2000-08-18 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2005.05.025
更新日期:2005-11-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:1979-09-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(97)00025-4
更新日期:1997-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/28.9.1385
更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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更新日期:2001-01-01 00:00:00
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doi:10.1016/s0008-6363(96)00185-x
更新日期:1997-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/25.7.565
更新日期:1991-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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更新日期:2009-07-15 00:00:00
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journal_title:Cardiovascular research
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更新日期:2021-01-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2014-02-01 00:00:00
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更新日期:2020-02-01 00:00:00
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更新日期:2003-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,多中心研究
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(98)00216-8
更新日期:1999-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvp055
更新日期:2009-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1093/cvr/cvaa068
更新日期:2020-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1093/cvr/9.5.621
更新日期:1975-09-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/19.7.433
更新日期:1985-07-01 00:00:00