Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension.

abstract：AIMS:Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function. Therefore, we investigated whether enhanced tubulin polymerization by TXL affects Na(v)1.5 function and expression and...

journal_title：Cardiovascular research

authors： Casini S,Tan HL,Demirayak I,Remme CA,Amin AS,Scicluna BP,Chatyan H,Ruijter JM,Bezzina CR,van Ginneken AC,Veldkamp MW

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate I(Ks), the slow component of the cardiac delayed rectifier current, and mutations in either gene cause the congenital Long QT syndrome. It is becoming increasingly well-recognized that multiprotein channel complexes co...

journal_title：Cardiovascular research

authors： Kupershmidt S,Yang IC,Sutherland M,Wells KS,Yang T,Yang P,Balser JR,Roden DM

更新日期：2002-10-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：:Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in l...

journal_title：Cardiovascular research

authors： Tester DJ,Ackerman MJ

更新日期：2005-08-15 00:00:00

abstract：:Myocardial function, flow and O2 consumption were compared in cardiac hypertrophy induced by pressure-loading (P) and by volume overloading (V). Increases in LV-to-body weight ratios in P and V hypertrophied hearts were comparable. Indices of LV function such as cardiac output, stroke volume, stroke work, minute work,...

journal_title：Cardiovascular research

authors： Malik AB,Geha AS

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:We, and others, have previously reported a strong correlation between increased inter-ventricular dispersion of repolarization and the occurrence of fatal arrhythmia in animal models of CHF. The existence of this and other such distinct electrophysiologic phenotypes in right (RV) vs. left ventricles (LV) cou...

journal_title：Cardiovascular research

authors： Chugh SS,Whitesel S,Turner M,Roberts CT Jr,Nagalla SR

更新日期：2003-02-01 00:00:00

abstract：:The static mechanical properties of major branches of the human arteries (common carotid artery, abdominal aorta, femoral artery, and brachial artery) were studied in 39 subjects, aged 6-81 years, using an ultrasonic phase locked echo tracking system that allows continuous transcutaneous measurement of the diameter of...

journal_title：Cardiovascular research

authors： Kawasaki T,Sasayama S,Yagi S,Asakawa T,Hirai T

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Earlier studies have revealed sarcolemmal (SL) defects in congestive heart failure due to myocardial infarction; however, the mechanisms of SL changes in the failing heart are poorly understood. Since congestive heart failure is associated with various metabolic abnormalities including a deficiency of carniti...

journal_title：Cardiovascular research

authors： Sethi R,Dhalla KS,Ganguly PK,Ferrari R,Dhalla NS

更新日期：1999-06-01 00:00:00

abstract：:The effect of chronic propranolol administration (2 mg.kg-1.d-1 for 14d) and withdrawal on microvascular perfusion was studied in rabbit myocardium. Fluorescein isothiocyanate-dextran was injected into four groups of anaesthetised open chest rabbits. Fluorescent microscopy was used to identify the perfused vessels and...

journal_title：Cardiovascular research

authors： Acad BA,Shenko JM,Eliades D,Weiss HR

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:The Na+ activated K+ channel (IK(Na)) may be activated during ischaemia when the intracellular Na+ concentration is raised. As ischaemia is also associated with intracellular acidification, the influence of intracellular pH on this K+ channel was investigated. METHODS:The effects of intracellular Na+ and H+ ...

journal_title：Cardiovascular research

authors： Veldkamp MW,Vereecke J,Carmeliet E

更新日期：1994-07-01 00:00:00

abstract：:Infarct size can be limited by reducing the determinants of infarct size or increasing collateral blood flow by treatment initiated before the ischaemic event. Reperfusion is the definitive treatment for permanently reducing infarct size and restoring some degree of contractile function to the affected myocardium. Inn...

journal_title：Cardiovascular research

authors： Granfeldt A,Lefer DJ,Vinten-Johansen J

更新日期：2009-07-15 00:00:00

abstract：OBJECTIVE:Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the impact of cilazaprilat on PMN dependent reperfusion injury in isolated g...

journal_title：Cardiovascular research

authors： Kupatt C,Habazettl H,Zahler S,Weber C,Becker BF,Messmer K,Gerlach E

更新日期：1997-12-01 00:00:00

abstract：:The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action potentials were studied for nine Class I anti-arrhythmic drugs using standard microelectrode techniques. The drugs were found to fall into three well-demarcated subgroups with "fast" (lignocaine...

journal_title：Cardiovascular research

authors： Campbell TJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To characterise the effect of coronary intra-arterial thrombosis upon the downstream vascular bed. BACKGROUND:The vascular response downstream from a coronary intra-arterial thrombus has not previously been characterised. We postulated that downstream vasoconstriction might result from the presence of endoth...

journal_title：Cardiovascular research

authors： Belcher PR,Vergroesen I,Drake-Holland AJ,Noble MI

更新日期：1995-11-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00

abstract：:Atrial fibrillation is the most common cardiac arrhythmia with an overall prevalence of almost 1%. Increasing prevalence and associated risks such as stroke and mortality have increased the need for better and more reliable therapeutic treatment. This has stimulated research to elucidate the pathophysiological mechani...

journal_title：Cardiovascular research

authors： Thijssen VL,Ausma J,Borgers M

更新日期：2001-10-01 00:00:00

abstract：AIM:The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia. METHODS AND RESULTS:Blood vessels were obtained from patients or mice and studied in culture. Reverse transcriptase-polymerase chain reaction and immunocytochemistry were used to...

journal_title：Cardiovascular research

authors： Cheong A,Li J,Sukumar P,Kumar B,Zeng F,Riches K,Munsch C,Wood IC,Porter KE,Beech DJ

更新日期：2011-02-01 00:00:00

abstract：:Regional distribution of myocardial blood flow (MBF) was examined in eight normal and nine pulmonary artery banded (PAB) pigs before and during pacing induced tachycardia (heart rates: 175, 225 and 275 beats X min-1) as well as during iv adenosine infusion (1.5 mg X kg-1 X min-1; maximal coronary vasodilatation) using...

journal_title：Cardiovascular research

authors： Manohar M

更新日期：1985-02-01 00:00:00

abstract：:Although fully explored in larger animals, the role of injection site and sample microsphere content on variability of coronary blood flow (CBF) measurement using the microsphere technique remains controversial in rats despite the fact that this species is extensively used in cardiovascular research. We therefore inve...

journal_title：Cardiovascular research

authors： Wicker PA,Healy BP

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situati...

journal_title：Cardiovascular research

authors： Hale SL,Kloner RA

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate the hypothesis that the oxygen demand of stimulated myocardium is downregulated and ischaemia avoided when oxygen supply is limited. METHODS:Isoprenaline stimulation during reduced coronary perfusion pressure or moderate coronary hypoxaemia was studied in relation to myocardial oxygen...

journal_title：Cardiovascular research

authors： Lee SC,Downey HF

更新日期：1993-08-01 00:00:00

abstract：:Since increases in blood pressure may be effectively controlled by hydraulic feedback by reducing the venous return through the inferior vena cava in proportion to the blood pressure this principle was applied using a totally implantable extravascular system consisting of a periaortic blood pressure sensor and a peric...

journal_title：Cardiovascular research

authors： Sideris DA,Vardas PE,Chrysos DN,Toumanidis ST,Michalis L,Moulopoulos SD

更新日期：1987-05-01 00:00:00

abstract：AIMS:Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR ...

journal_title：Cardiovascular research

authors： Ma KL,Liu J,Wang CX,Ni J,Zhang Y,Wu Y,Lv LL,Ruan XZ,Liu BC

更新日期：2013-12-01 00:00:00

abstract：:A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complicatio...

journal_title：Cardiovascular research

authors： Chen L,Li X,Chen M,Feng Y,Xiong C

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Vascular smooth muscle cell (VSMC) de-differentiation is a prerequisite for migration from the tunica media to the intima after vascular injury. Integrin cell adhesion molecules participate in VSMC phenotype modulation. Alpha 8 beta 1 integrin is a differentiation marker of VSMCs and its knockdown heightens m...

journal_title：Cardiovascular research

authors： Zargham R,Thibault G

更新日期：2006-07-01 00:00:00

abstract：Aims:Hypertensive cardiac hypertrophy is associated with reduced coronary flow reserve, but its impact on coronary flow regulation and vasomotor function remains incompletely understood and requires further investigation. Methods and results:Left ventricular hypertrophy was induced in mice by transverse aortic coarcta...

journal_title：Cardiovascular research

authors： Tsai SH,Lu G,Xu X,Ren Y,Hein TW,Kuo L

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:The aim was to correlate the relative abilities of amiodarone, lignocaine, and penticainide in suppressing ventricular tachyarrhythmias in response to coronary artery occlusion with their relative abilities to prolong ventricular functional refractory periods and to reduce intraventricular conduction velociti...

journal_title：Cardiovascular research

authors： Li JY,Northover BJ

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：:The structural nature of fibrillar collagen involved in the replacement fibrosis which accompanies discrete areas of cell necrosis remains uncertain, as does its influence on the diastolic and systolic stiffness of the intact myocardium. This study, using 15 micron diameter microsphere embolisation of the rat myocardi...

journal_title：Cardiovascular research

authors： Carroll EP,Janicki JS,Pick R,Weber KT

更新日期：1989-08-01 00:00:00