Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats.

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：:Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (MPTP). This transition causes mitochondria to become uncoupled and capable of hydrolysing rather than synthesising ATP. Unrestrai...

journal_title：Cardiovascular research

authors： Halestrap AP,Clarke SJ,Javadov SA

更新日期：2004-02-15 00:00:00

abstract：OBJECTIVE:Anoxia followed by reoxygenation (A/R) increases endothelial cell superoxide (O2-) generation which is implicated in E-selectin overexpression. The mechanisms which govern these processes are not fully understood and therefore the goal of our study was to determine the functional importance of NADPH oxidase i...

journal_title：Cardiovascular research

authors： Rupin A,Paysant J,Sansilvestri-Morel P,Lembrez N,Lacoste JM,Cordi A,Verbeuren TJ

更新日期：2004-08-01 00:00:00

abstract：:Ischemic preconditioning is a well-established phenomenon first described in experimental preparations in which brief episodes of ischemia/reperfusion applied prior to a longer coronary artery occlusion reduce myocardial infarct size. There are ample correlates of ischemic preconditioning in the clinical realm. Precon...

journal_title：Cardiovascular research

authors： Kloner RA,Rezkalla SH

更新日期：2006-05-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Persistent atrial fibrillation (AF) results in an impairment of atrial function. In order to elucidate the mechanism behind this phenomenon, we investigated the gene expression of proteins influencing calcium handling. METHODS:Right atrial appendages were obtained from eight patients with paroxysmal AF, ten ...

journal_title：Cardiovascular research

authors： Brundel BJ,van Gelder IC,Henning RH,Tuinenburg AE,Deelman LE,Tieleman RG,Grandjean JG,van Gilst WH,Crijns HJ

更新日期：1999-05-01 00:00:00

abstract：:This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14...

journal_title：Cardiovascular research

authors： Sen S,Tarazi RC,Bumpus FM

更新日期：1976-03-01 00:00:00

abstract：AIMS:Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS:Experimental myocardial infarction (MI) was created in CTSL-defi...

journal_title：Cardiovascular research

authors： Sun M,Chen M,Liu Y,Fukuoka M,Zhou K,Li G,Dawood F,Gramolini A,Liu PP

更新日期：2011-02-01 00:00:00

abstract：:The acute haemodynamic effects of taurine were studied in normal and in beta blocker (propranolol) or calcium antagonist (diltiazem) treated rabbits and in rabbits with experimentally produced chronic aortic regurgitation. The administration of taurine (25 mg.kg-1) did not affect heart rate and left ventricular end di...

journal_title：Cardiovascular research

authors： Awata N,Azuma J,Hamaguchi T,Tanaka Y,Ohta H,Takihara K,Harada H,Sawamura A,Kishimoto S

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. METHODS:In situ hybridizations with Cx40 and ...

journal_title：Cardiovascular research

authors： Van Kempen MJ,Vermeulen JL,Moorman AF,Gros D,Paul DL,Lamers WH

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The aim was to examine the role of nitric oxide (NO) in the myocardial microcirculation. METHODS:Open chest anaesthetised dogs received intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA; 0.5 mg.kg-1 over 30 min). Myocardial microvascular extraction fraction of a small hydrophilic solute (technetium ...

journal_title：Cardiovascular research

authors： Hansen PR,Haunsø S

更新日期：1995-06-01 00:00:00

abstract：:Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate clearly have robust NO-like effects in humans, including blood pressure reduction, inhibition of platelet aggregation, and vasoprot...

journal_title：Cardiovascular research

authors： Lundberg JO,Carlström M,Larsen FJ,Weitzberg E

更新日期：2011-02-15 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Chlamydia pneumoniae infection has been associated with atherosclerosis, although the mechanisms by which C. pneumoniae contribute to atherogenesis remain unclear. Altered production of nitric oxide, a known bactericidal and anti-inflammatory agent, represents one possible mechanistic link. To examine this is...

journal_title：Cardiovascular research

authors： Chesebro BB,Blessing E,Kuo CC,Rosenfeld ME,Puolakkainen M,Campbell LA

更新日期：2003-10-15 00:00:00

abstract：:The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. Both cellular and extracellular factors are involved in the remodeling process and it is th...

journal_title：Cardiovascular research

authors： Deschamps AM,Spinale FG

更新日期：2006-02-15 00:00:00

abstract：:Increased Na/Ca exchange (NCX) expression may be part of the genetic reprogramming in cardiac remodeling. In this review we address the following questions: (1) Is increased NCX activity a general feature of cardiac remodeling in hypertrophy and heart failure? (2) How does this contribute to the contractile and electr...

journal_title：Cardiovascular research

authors： Sipido KR,Volders PG,Vos MA,Verdonck F

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Lower limb perfusion following arterial occlusion depends on the recruitment of collateral vessels. Blood flow through these collateral vessels may be jeopardized by hypersensitivity to vasoconstriction by serotonin (5-HT), as has been reported during hyperlipidemia and diabetes. Therefore the aim of this stu...

journal_title：Cardiovascular research

authors： Janiak P,Lainée P,Grataloup Y,Luyt CE,Bidouard JP,Michel JB,O'Connor SE,Herbert JM

更新日期：2002-11-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Most previous investigations focused on the role of homocysteine as direct pathogenetic factor for these adverse vascular events. However, the exact pathophysiological mechanism is still unknown. In this review we discuss the hypothesis tha...

journal_title：Cardiovascular research

authors： Riksen NP,Rongen GA,Blom HJ,Russel FG,Boers GH,Smits P

更新日期：2003-08-01 00:00:00

abstract：:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogeno...

journal_title：Cardiovascular research

authors： Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DM

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) cause extracellular matrix degradation and may be involved in the rupture of atherosclerotic plaques by degrading fibrous cap, resulting in the intravascular thrombus formation. Here we examined whether local overexpression of MMP-9 alters the characteristics of arteriosclerot...

journal_title：Cardiovascular research

authors： Morishige K,Shimokawa H,Matsumoto Y,Eto Y,Uwatoku T,Abe K,Sueishi K,Takeshita A

更新日期：2003-02-01 00:00:00

abstract：AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...

journal_title：Cardiovascular research

authors： Kanno Y,Into T,Lowenstein CJ,Matsushita K

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE AND METHODS:In this study, we investigated whether Ca(2+) transients are altered in Purkinje cell aggregates dispersed from the subendocardium overlying the infarcted zone of the left ventricle (IZPCs) 48 h after coronary artery occlusion. To do so, we combined epifluorescent imaging with microelectrode recor...

journal_title：Cardiovascular research

authors： Boyden PA,Barbhaiya C,Lee T,ter Keurs HE

更新日期：2003-03-01 00:00:00

abstract：:The theory related to the loss of R waves and appearance of Q waves in acute myocardial infarction is discussed. A method of praecordial mapping of RS ratio changes and the appearance of Q waves that occur in acute myocardial infarction is described. The serial changes in these electrocardiographic signs in 17 patient...

journal_title：Cardiovascular research

authors： Selwyn AP,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：:Atherosclerosis is characterized by a persistent, low-grade inflammation of the arterial wall. Monocytes and monocyte-derived macrophages play a pivotal role in the various stages of atherosclerosis. In the past few years, metabolic reprogramming has been identified as an important controller of myeloid cell activatio...

journal_title：Cardiovascular research

authors： van Tuijl J,Joosten LAB,Netea MG,Bekkering S,Riksen NP

更新日期：2019-07-01 00:00:00

abstract：CONDENSED ABSTRACT:We analyzed actomyosin cross-bridge kinetics in human atrial and ventricular muscle strip preparations by using sinusoidal length changes from 0.1 to 60 Hz. The minimum stiffness frequency was higher in atrial than in ventricular human myocardium and lower in failing than in non-failing left ventricu...

journal_title：Cardiovascular research

authors： Ruf T,Schulte-Baukloh H,Lüdemann J,Posival H,Beyersdorf F,Just H,Holubarsch C

更新日期：1998-12-01 00:00:00

abstract：AIMS:Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigat...

journal_title：Cardiovascular research

authors： Petrovic D,Haba-Rubio J,de Mestral Vargas C,Kelly-Irving M,Vineis P,Kivimäki M,Nyberg S,Gandini M,Bochud M,Vollenweider P,d'Errico A,Barros H,Fraga S,Goldberg M,Zins M,Steptoe A,Delpierre C,Heinzer R,Carmeli C,Chade

更新日期：2020-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the effects of long-term treatment with an alpha 1 blocker, bunazosin hydrochloride, on blood pressure, heart weight, myocardial contractility, and ventricular myosin isoenzyme pattern in spontaneously hypertensive rats (SHR). DESIGN:Bunazosin hydrochloride was given orally i...

journal_title：Cardiovascular research

authors： Takeda N,Nakamura I,Ohkubo T,Iwai T,Tanamura A,Nagano M

更新日期：1991-07-01 00:00:00

abstract：:Little information exists regarding the effects of coronary artery occlusion on the distribution and actions of antiarrhythmic agents. We administered aprindine to dogs before, 5 min after, and 24 h after one-stage left anterior descending coronary artery (LAD) occlusion. Coronary artery occlusion performed after apri...

journal_title：Cardiovascular research

authors： Nattel S,Pedersen DH,Zipes DP

更新日期：1981-02-01 00:00:00

abstract：:Many observational studies and experimental and animal studies have demonstrated that estrogen therapy (ET) or hormone therapy (HT) significantly reduces the risk of coronary heart disease. Nonetheless, recent randomized controlled trials and the Nurses' Health Study in secondary prevention demonstrate trends toward a...

journal_title：Cardiovascular research

authors： Koh KK,Yoon BK

更新日期：2006-04-01 00:00:00