Oxidized LDL induces ventricular myocyte damage and abnormal electrical activity--role of lipid hydroperoxides.

abstract：AIMS:Insulin (Ins) resistance (IRES) associates to increased cardiovascular risk as observed in metabolic syndrome. Chronic stimulation of beta-adrenergic receptors (betaAR) due to exaggerated sympathetic nervous system activity is involved in the pathogenesis of IRES. The cellular levels of G protein coupled receptor ...

journal_title：Cardiovascular research

authors： Cipolletta E,Campanile A,Santulli G,Sanzari E,Leosco D,Campiglia P,Trimarco B,Iaccarino G

更新日期：2009-12-01 00:00:00

abstract：AIMS:Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG on homocysteine (Hcy)-induced T-cell activation and potential signal pathways involved in atherosclerotic formation. METHODS AND RESULTS:The CD28...

journal_title：Cardiovascular research

authors： Ma K,Lv S,Liu B,Liu Z,Luo Y,Kong W,Xu Q,Feng J,Wang X

更新日期：2013-02-01 00:00:00

abstract：AIMS:GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload...

journal_title：Cardiovascular research

authors： Han M,Yang Z,Sayed D,He M,Gao S,Lin L,Yoon S,Abdellatif M

更新日期：2012-03-15 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：:Although fully explored in larger animals, the role of injection site and sample microsphere content on variability of coronary blood flow (CBF) measurement using the microsphere technique remains controversial in rats despite the fact that this species is extensively used in cardiovascular research. We therefore inve...

journal_title：Cardiovascular research

authors： Wicker PA,Healy BP

更新日期：1989-05-01 00:00:00

abstract：:The interest in mouse electrophysiology is expanding fast, despite the marked differences between mouse and man. Different methods have become available to analyse the electrical activity in the mouse heart in vivo. The mouse genome can be altered with relative ease, which allows the molecular dissection of the variou...

journal_title：Cardiovascular research

authors： Wehrens XH,Kirchhoff S,Doevendans PA

更新日期：2000-01-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to enhanced free radical production that in turn causes DNA strand breakage culminating in poly(ADP-ribose) polymerase (PARP) activation and mitochondrial and cellular d...

journal_title：Cardiovascular research

authors： Szántó M,Rutkai I,Hegedus C,Czikora Á,Rózsahegyi M,Kiss B,Virág L,Gergely P,Tóth A,Bai P

更新日期：2011-12-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：:Little information exists regarding the effects of coronary artery occlusion on the distribution and actions of antiarrhythmic agents. We administered aprindine to dogs before, 5 min after, and 24 h after one-stage left anterior descending coronary artery (LAD) occlusion. Coronary artery occlusion performed after apri...

journal_title：Cardiovascular research

authors： Nattel S,Pedersen DH,Zipes DP

更新日期：1981-02-01 00:00:00

abstract：:The theoretical possibilities and the practical limitations of the Xenon-133 (133Xe) method for the study of regional myocardial perfusion in man are discussed. The techniques for data acqusition and processing developed over the past 5 years are described in detail. Illustrative examples of experimental findings are ...

journal_title：Cardiovascular research

authors： Maseri A,L'abbate A,Michelassi C,Pesola A,Pisani P,Marzilli M,De Nes M,Mancini P

更新日期：1977-07-01 00:00:00

abstract：OBJECTIVE:Evidence suggests important relationships among chronic inflammatory processes, endothelial dysfunction, hypertension and target organ damage. The present study examined the effects of chronic treatment with an anti-inflammatory p38 mitogen-activated protein kinase (MAPK) inhibitor (SB-239063AN) in the N(omeg...

journal_title：Cardiovascular research

authors： Olzinski AR,McCafferty TA,Zhao SQ,Behm DJ,Eybye ME,Maniscalco K,Bentley R,Frazier KS,Milliner CM,Mirabile RC,Coatney RW,Willette RN

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that cardiac protection by ischaemic preconditioning wanes before contractile function recovers; thus stunning is insufficient to cause preconditioning. To test whether reduced contractile effort is necessary for preconditioning induced protection, the effect on myocardial infarct ...

journal_title：Cardiovascular research

authors： Matsuda M,Catena TG,Vander Heide RS,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：:In pulmonary arterial hypertension (PAH), right ventricular (RV) adaptation is essential to overcome the chronic increases in RV pressure overload. Ultimately, RV compensatory mechanisms are not sufficient and patients succumb to RV failure. The processes underlying the transition of RV adaptation to RV failure are no...

journal_title：Cardiovascular research

authors： van der Bruggen CEE,Tedford RJ,Handoko ML,van der Velden J,de Man FS

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effects of a calcium antagonist (diltiazem) and a catecholamine (noradrenaline) on extracellular potassium accumulation during global ischaemia. METHODS:Extracellular potassium concentration ([K+]e) was measured during 30 min global ischaemia in the isolated rat heart using a v...

journal_title：Cardiovascular research

authors： Mitani A,Kinoshita K,Fukamachi K,Sakamoto M,Kurisu K,Fukumura F,Tsuruhara Y,Nakashima A,Tokunaga K

更新日期：1992-11-01 00:00:00

abstract：AIMS:ATP sensitive K(+) channels (K(ATP)) sense adenine nucleotide concentrations and thus couple the metabolic state of the cell to membrane potential. The hetero-octameric complex of a sulphonylurea receptor (SUR2B) and an inwardly rectifying K(+) channel (Kir6.1) and the corresponding native channel in smooth muscle...

journal_title：Cardiovascular research

authors： Farzaneh T,Tinker A

更新日期：2008-09-01 00:00:00

abstract：AIMS:Nonsense mutations in the SCN5A gene result in truncated, non-functional derivatives of the cardiac Na+ channel and thus cause arrhythmias. Studies of other genes suggest that pathogenic phenotypes of nonsense mutations may be alleviated by enhancing readthrough, which enables ribosomes to ignore premature termina...

journal_title：Cardiovascular research

authors： Teng S,Gao L,Paajanen V,Pu J,Fan Z

更新日期：2009-08-01 00:00:00

abstract：:There is mounting interest in the use of the monophasic action potential for electrophysiological investigation of regional myocardial ischaemia. There is, however, no systematic study of the relation between the changes in monophasic action potential and regional myocardial blood flow. In this study monophasic action...

journal_title：Cardiovascular research

authors： Kingaby RO,Lab MJ,Cole AW,Palmer TN

更新日期：1986-10-01 00:00:00

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：:Sprouting angiogenesis is an invasive process that involves proteolytic activities required for the degradation of the endothelial basement membrane, cell migration with removal of obstructing matrix proteins, and generation of space in the matrix to allow endothelial cells to form a proper lumen. In the last decade i...

journal_title：Cardiovascular research

authors： van Hinsbergh VW,Koolwijk P

更新日期：2008-05-01 00:00:00

abstract：AIMS:Elderly patients with heart failure with reduced ejection fraction (HFrEF) have worse prognosis and less often receive guideline-recommended therapies. We aim to better understand the underlying pathophysiological processes associated with aging in HFrEF potentially leading to targeted therapies in this vulnerable...

journal_title：Cardiovascular research

authors： Ferreira JP,Ouwerkerk W,Santema BT,van Veldhuisen DJ,Lang CC,Ng LL,Anker SD,Dickstein K,Metra M,Cleland JGF,Nilesh SJ,Filippatos G,Aboumsallem JP,de Boer RA,Figarska S,Sama IE,Voors AA,Zannad F

更新日期：2020-10-01 00:00:00

abstract：:Ischemic preconditioning is a well-established phenomenon first described in experimental preparations in which brief episodes of ischemia/reperfusion applied prior to a longer coronary artery occlusion reduce myocardial infarct size. There are ample correlates of ischemic preconditioning in the clinical realm. Precon...

journal_title：Cardiovascular research

authors： Kloner RA,Rezkalla SH

更新日期：2006-05-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive he...

journal_title：Cardiovascular research

authors： Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JM

更新日期：1998-03-01 00:00:00

abstract：:Although the existence of t-tubules in mammalian cardiac ventricular myocytes has been recognized for a long time, it now appears that their structure and function are more complex than previously believed. Recent work has provided evidence that many of the key proteins underlying excitation-contraction coupling are l...

journal_title：Cardiovascular research

authors： Orchard C,Brette F

更新日期：2008-01-15 00:00:00

abstract：OBJECTIVE:Resistin belongs to a family of cysteine-rich secreted polypeptides that are mainly produced by monocytes/macrophages in humans. Recently, high concentrations of resistin were shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation. We examined if resistin was secreted f...

journal_title：Cardiovascular research

authors： Jung HS,Park KH,Cho YM,Chung SS,Cho HJ,Cho SY,Kim SJ,Kim SY,Lee HK,Park KS

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Mechanoelectric Feedback, a mechanical intervention inducing an electrical change, is gaining credence as a cause of cardiac arrhythmia in the clinical situation. However, the precise mechanism is unknown. To elucidate this we investigated mechanical and chemical modulation of stretch-induced premature ventri...

journal_title：Cardiovascular research

authors： Dick DJ,Lab MJ

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Activin-like kinase receptor 1 (ALK1) is a transforming growth factor (TGF)-beta type I receptor expressed in vascular mesenchyme, yet its function in vascular mesenchymal cells (VMC) is unclear. We examined ALK1 expression in human coronary atherosclerotic lesions and bovine and human VMC undergoing cellular...

journal_title：Cardiovascular research

authors： Yao Y,Zebboudj AF,Torres A,Shao E,Boström K

更新日期：2007-05-01 00:00:00

abstract：:The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal art...

journal_title：Cardiovascular research

authors： Berry CL,Greenwald SE,Menahem N

更新日期：1981-07-01 00:00:00

abstract：:The effect of catheterisation on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheter...

journal_title：Cardiovascular research

authors： Madsen JK,Garbarsch C,Nielsen PE

更新日期：1979-09-01 00:00:00