ROS signalling between endothelial cells and cardiac cells.


:The heart contains not only cardiomyocytes but also other cell types such as endothelial cells and fibroblasts. Functional crosstalk among these cell types is important for normal cardiac function and is also involved in disease pathophysiology. Recent data indicate that redox signalling within and between endothelial cells and cardiomyocytes, both through direct and indirect mechanisms, is an important aspect of the functional communication between these cell types. Such signalling influences contractile function, cardiomyocyte growth, hypertrophy, angiogenesis, and fibrosis, and may play an important role in cardiac remodelling in disease.


Cardiovasc Res


Cardiovascular research


Zhang M,Shah AM




Has Abstract


2014-05-01 00:00:00














  • Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor.

    abstract:OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Armstrong S,Downey JM,Ganote CE

    更新日期:1994-01-01 00:00:00

  • Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?

    abstract::The importance of the vascular adventitia is increasingly being recognized not only in vascular disease but also in normal maintenance and homeostasis of vessels. Activation of the adventitia and its resident fibrocytic cells in response to injury, stretch, cytokines, and hormones has been shown to stimulate different...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Haurani MJ,Pagano PJ

    更新日期:2007-09-01 00:00:00

  • Organotypic slice culture from human adult ventricular myocardium.

    abstract:AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

    更新日期:2012-01-01 00:00:00

  • Ventricular arrhythmias induced by chemically modified intrinsic cardiac neurones.

    abstract:OBJECTIVE:The aim was to investigate whether intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias. METHODS:Nicotinic, muscarinic, beta adrenergic, peptidergic, and amino acidergic agonists, as well as purinergic compounds, were individually administered in microliter quantities adjacent...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Huang MH,Wolf SG,Armour JA

    更新日期:1994-05-01 00:00:00

  • Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.

    abstract:AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

    更新日期:2016-01-01 00:00:00

  • Acute pericardial distension in pigs: effect of fluid conductance on body surface electrocardiogram QRS size.

    abstract:OBJECTIVES:Pericardial effusion has long been associated with low voltage of the surface electrocardiogram and its clinical utility is well known. The cause of this reduced QRS voltage has usually been attributed to short circuiting of the impulses by the pericardial fluid, but its precise mechanism has not been clearl...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Karatay CM,Fruehan CT,Lighty GW Jr,Spear RM,Smulyan H

    更新日期:1993-06-01 00:00:00

  • Post implantation viability in canine allograft heart valves.

    abstract::Known viable allograft canine pulmonary valves were inserted in an isotopic position ensuring normal physiological function and simulating the clinical situation. Valves removed at periods up to eight weeks were assessed for viability using previously established criteria of tissue culture and protein and collagen syn...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Wheatley DJ,McGregor CG

    更新日期:1977-01-01 00:00:00

  • Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement.

    abstract:OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Armstrong S,Ganote CE

    更新日期:1994-07-01 00:00:00

  • Separation of the oscillatory current from other currents in cardiac Purkinje fibres.

    abstract::An oscillatory current (Ios) can be recorded after depolarising clamps of a given amplitude and duration. To determine whether Ios depends on other currents activated during the clamp, the Ios was investigated in the absence and in the presence of 4-aminopyridine (4-AP) and cesium (Cs). The following results were obta...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Mugelli A

    更新日期:1982-11-01 00:00:00

  • Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways.

    abstract:Aims:The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis and acute coronary syndromes (ACS). However, its role in arterial thrombus formation remains unknown. We investigated whether LOX-1 plays a role in arteria...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Akhmedov A,Camici GG,Reiner MF,Bonetti NR,Costantino S,Holy EW,Spescha RD,Stivala S,Schaub Clerigué A,Speer T,Breitenstein A,Manz J,Lohmann C,Paneni F,Beer JH,Lüscher TF

    更新日期:2017-04-01 00:00:00

  • Oxidized LDL induces ventricular myocyte damage and abnormal electrical activity--role of lipid hydroperoxides.

    abstract:OBJECTIVE:It was our aim to investigate effects of human LDL, copper-, or AAPH-oxidized over different periods of time to different degrees (ox-LDL), on viability and electrophysiological parameters of isolated ventricular myocytes of guinea pigs. METHODS:Guinea pig ventricular myocytes were incubated with ox-LDL or n...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Zorn-Pauly K,Schaffer P,Pelzmann B,Bernhart E,Wei G,Lang P,Ledinski G,Greilberger J,Koidl B,Jürgens G

    更新日期:2005-04-01 00:00:00

  • Mitochondrial plasticity in classical ischemic preconditioning-moving beyond the mitochondrial KATP channel.

    abstract::Ischemic preconditioning is a powerful biologic phenomenon that activates innate cell survival programs to protect the heart from ischemic injury. The preponderance of research into classical ischemic preconditioning has focused on signaling pathways orchestrating cardioprotection. Conceptually classified into trigger...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Minners J,McLeod CJ,Sack MN

    更新日期:2003-07-01 00:00:00

  • Strategies to achieve coronary arterial plaque stabilization.

    abstract::Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool, an abundance of inflammatory cells and mediators, a reduced smooth muscle cell and collagen content and a thin overlying fibrous cap. Potential...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Rabbani R,Topol EJ

    更新日期:1999-02-01 00:00:00

  • The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF.

    abstract:BACKGROUND:Clinical trials suggest that sotalol and dofetilide are much more effective in preventing atrial fibrillation (AF) than in terminating it. This study evaluated potential mechanisms of discordant sotalol and dofetilide effects on AF termination vs. prevention. METHODS:We applied 240-electrode epicardial mapp...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Derakhchan K,Villemaire C,Talajic M,Nattel S

    更新日期:2001-04-01 00:00:00

  • Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control.

    abstract:AIMS:Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrhythmia development in these patients. To understand the underlying mec...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Rathjens FS,Blenkle A,Iyer LM,Renger A,Syeda F,Noack C,Jungmann A,Dewenter M,Toischer K,El-Armouche A,Müller OJ,Fabritz L,Zimmermann WH,Zelarayan LC,Zafeiriou MP

    更新日期:2020-08-10 00:00:00

  • Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

    abstract:Aims:Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in m...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Gaul DS,Weber J,van Tits LJ,Sluka S,Pasterk L,Reiner MF,Calatayud N,Lohmann C,Klingenberg R,Pahla J,Vdovenko D,Tanner FC,Camici GG,Eriksson U,Auwerx J,Mach F,Windecker S,Rodondi N,Lüscher TF,Winnik S,Matter CM

    更新日期:2018-07-01 00:00:00

  • Changes in right ventricular relaxation during acute anterior myocardial infarction in pigs.

    abstract::To determine the effect of an anteroseptal myocardial infarction on right ventricular systolic and diastolic function, we studied 12 pigs before and 1 h after left anterior descending coronary artery occlusion. Total arterial occlusion was achieved by the percutaneous, transcatheter placement of a 1 mm Teflon plug int...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Lancaster LD,Kern KB,Morrison DA,Olajos M,Goldman S

    更新日期:1989-01-01 00:00:00

  • Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9.

    abstract:AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

    更新日期:2008-04-01 00:00:00

  • Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure.

    abstract:OBJECTIVE:Experimental evidence suggests that modulation of myocardial substrate metabolism can markedly affect the progression of chronic heart failure (HF). We tested whether the inhibition of carnitine palmitoyl transferase-I (CPT-I), the enzyme regulating mitochondrial fatty acid oxidation, slows left ventricular r...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Lionetti V,Linke A,Chandler MP,Young ME,Penn MS,Gupte S,d'Agostino C,Hintze TH,Stanley WC,Recchia FA

    更新日期:2005-06-01 00:00:00

  • Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity.

    abstract::Circulating concentrations of leucocyte elastase and free radical activity were measured in 11 adults undergoing cardiopulmonary bypass. In all patients the bypass procedure was associated with pronounced changes in plasma elastase concentrations, and peak enzyme concentrations correlated closely with the duration of ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Hind CR,Griffin JF,Pack S,Latchman YE,Drake HF,Jones HM,Brostoff J,Dormandy TL,Treasures T

    更新日期:1988-01-01 00:00:00

  • Differential regional responses of myocardial interstitial noradrenaline levels to coronary occlusion.

    abstract:OBJECTIVE:The aim was to investigate the influence of coronary occlusion on myocardial interstitial noradrenaline levels in the ischaemic and non-ischaemic regions, using the dialysis technique. METHODS:In nine anaesthetised cats, regional ischaemia was produced by occlusion of the left anterior descending coronary ar...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Akiyama T,Yamazaki T,Ninomiya I

    更新日期:1993-05-01 00:00:00

  • Voltage-activated Ca(2+) channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca(2+) current.

    abstract:AIMS:Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) currents have never been studied in these two vessels. Our study was init...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Smirnov SV,Loutzenhiser K,Loutzenhiser R

    更新日期:2013-02-01 00:00:00

  • Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling.

    abstract::Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide synthase (eNOS and nNOS, respectively). There are increasing data indicating that NO modulates various proteins involved in excitation...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Lim G,Venetucci L,Eisner DA,Casadei B

    更新日期:2008-01-15 00:00:00

  • Effects of low-flow ischemia on the positive inotropic action of angiotensin II in isolated rabbit and rat hearts.

    abstract:OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

    更新日期:1997-01-01 00:00:00

  • Up-regulation of endothelial stretch-activated cation channels by fluid shear stress.

    abstract:OBJECTIVE:Stretch-activated cation channels (SAC) have been suggested to act as endothelial mechanosensors for hemodynamic forces. Ca(2+) influx through SAC could induce an intracellular Ca(2+) signal stimulating Ca(2+)-dependent synthesis of vasodilators like NO, prostacyclin, or EDHF. In the present study we tested w...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Brakemeier S,Eichler I,Hopp H,Köhler R,Hoyer J

    更新日期:2002-01-01 00:00:00

  • Update on therapeutic neovascularization.

    abstract::Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is an...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Cao Y,Hong A,Schulten H,Post MJ

    更新日期:2005-02-15 00:00:00

  • Down-regulation of the ERK1 and ERK2 mitogen-activated protein kinases using antisense oligonucleotides inhibits intimal hyperplasia in a porcine model of coronary balloon angioplasty.

    abstract:OBJECTIVE:Neointimal hyperplasia is a central feature in the pathogenesis of a variety of vascular pathologies. Mitogen-activated protein kinases (MAPK) are involved in the downstream transduction of signals from receptors for many of the molecules known to be instrumental in this process and thus represent a potential...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Liu B,Fisher M,Groves P

    更新日期:2002-06-01 00:00:00

  • Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.

    abstract:AIMS:Vascular inflammation is a major atherogenic factor and Toll-like receptor (TLR) 2 ligands, including bacterial and serum lipoproteins, seem to be involved in atherogenesis. On this basis, we analysed the effect of lipoproteins and different lipid components on TLR2-dependent signalling. METHODS AND RESULTS:In TL...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Dueñas AI,Aceves M,Fernández-Pisonero I,Gómez C,Orduña A,Crespo MS,García-Rodríguez C

    更新日期:2008-08-01 00:00:00

  • The role of oxidative stress in the genesis of heart disease.

    abstract::Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery...

    journal_title:Cardiovascular research

    pub_type: 社论,评审


    authors: Singal PK,Khaper N,Palace V,Kumar D

    更新日期:1998-12-01 00:00:00

  • Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.

    abstract:AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

    更新日期:2016-09-01 00:00:00