ROS signalling between endothelial cells and cardiac cells.

Abstract:

:The heart contains not only cardiomyocytes but also other cell types such as endothelial cells and fibroblasts. Functional crosstalk among these cell types is important for normal cardiac function and is also involved in disease pathophysiology. Recent data indicate that redox signalling within and between endothelial cells and cardiomyocytes, both through direct and indirect mechanisms, is an important aspect of the functional communication between these cell types. Such signalling influences contractile function, cardiomyocyte growth, hypertrophy, angiogenesis, and fibrosis, and may play an important role in cardiac remodelling in disease.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Zhang M,Shah AM

doi

10.1093/cvr/cvu050

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

249-57

issue

2

eissn

0008-6363

issn

1755-3245

pii

cvu050

journal_volume

102

pub_type

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