Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease.

abstract：OBJECTIVE:Activin-like kinase receptor 1 (ALK1) is a transforming growth factor (TGF)-beta type I receptor expressed in vascular mesenchyme, yet its function in vascular mesenchymal cells (VMC) is unclear. We examined ALK1 expression in human coronary atherosclerotic lesions and bovine and human VMC undergoing cellular...

journal_title：Cardiovascular research

authors： Yao Y,Zebboudj AF,Torres A,Shao E,Boström K

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Recently, we have found that rat CMV (RCMV) infected smooth muscle cells (SMCs) in rat carotid arteries when administered 14 days after balloon injury. In the present study we investigated (1) the long term effects of CMV infection on neointimal cross-sectional area, and (2) whether the phenotype of the intim...

journal_title：Cardiovascular research

authors： Persoons MC,Daemen MJ,van Kleef EM,Grauls GE,Wijers E,Bruggeman CA

更新日期：1997-11-01 00:00:00

abstract：STUDY OBJECTIVE:It has been suggested that oxygenation of the isolated, crystalloid perfused, Langendorff rabbit heart is inadequate and that consequent hypoxia limits mechanical performance. The isolated working rabbit heart, which has a higher oxygen requirement than the Langendorff preparation, was used to investiga...

journal_title：Cardiovascular research

authors： Murashita T,Kempsford RD,Hearse DJ

更新日期：1991-03-01 00:00:00

abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...

journal_title：Cardiovascular research

authors： Iyoda I,Takahashi H,Lee LC,Okajima H,Inoue A,Sasaki S,Takeda K,Yoshimura M,Ijichi H

更新日期：1986-04-01 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：OBJECTIVE:The endothelium is a newly recognised target tissue of parathyroid hormone (PTH). It is not clear whether hyperparathyroidism affects endothelial function and whether parathyroidectomy (Ptx) has an influence on arterial vessel wall properties. We studied brachial flow-mediated vasodilation (FMD) and brachial ...

journal_title：Cardiovascular research

authors： Kosch M,Hausberg M,Vormbrock K,Kisters K,Gabriels G,Rahn KH,Barenbrock M

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Increased expression of the cardiac natriuretic peptides (NP), atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) is observed during chronic hemodynamic overload. The mechanisms underlying this process are not fully understood. In vitro, endothelin 1 (ET-1) is a powerful stimulator of cardiac...

journal_title：Cardiovascular research

authors： Bianciotti LG,de Bold AJ

更新日期：2001-03-01 00:00:00

abstract：AIMS:P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and decreased preglomer...

journal_title：Cardiovascular research

authors： Gordienko D,Povstyan O,Sukhanova K,Raphaël M,Harhun M,Dyskina Y,Lehen'kyi V,Jama A,Lu ZL,Skryma R,Prevarskaya N

更新日期：2015-02-01 00:00:00

abstract：:When the vagus nerves are stimulated with one burst of pulses per minute, but each burst is placed at a different time in the cardiac cycle, a "vagal effect curve" can be derived which displays the changes in cardiac cycle length (CCL) as a function of the elapsed time from the stimulus. This curve consists of a prima...

journal_title：Cardiovascular research

authors： Wallick DW,Valencic F,Fratianne RB,Levy MN

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evalua...

journal_title：Cardiovascular research

authors： Zhang Y,Oliver JR,Horowitz JD

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Alkalinizing agents reverse cardiotoxicity of a variety of sodium channel blockers, including tricyclic antidepressants, but their mechanisms of action are poorly understood. PURPOSE:To establish the mechanisms by which alkalinization diminishes the sodium channel blocking action of imipramine. METHODS:The...

journal_title：Cardiovascular research

authors： Bou-Abboud E,Nattel S

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:The potential use of bone marrow stromal cells (MSCs) as a cellular therapy for chronic cardiac diseases relies on the ability of the cell to replicate extensively in vitro and to give rise to myogenic cells that can replace the damaged cardiomyocytes. For this reason the present study investigated the replic...

journal_title：Cardiovascular research

authors： Liu Y,Song J,Liu W,Wan Y,Chen X,Hu C

更新日期：2003-05-01 00:00:00

abstract：:To test hypothesis that adrenergic neurotransmission is impaired in acute myocardial ischaemia, we studied contractile function of normal and ischaemic myocardium after coronary artery occlusion. For each area we compared the contractile response to left sympathetic nerve stimulation (LSS) with the response to exogeno...

journal_title：Cardiovascular research

authors： Martins JB,Kerber RE,Marcus ML,Laughlin DL,Levy DM

更新日期：1980-02-01 00:00:00

abstract：:The distribution of neuropeptide Y (NPY) in the rat cardiovascular system has been examined by radioimmunoassay, chromatographic analysis of tissue extracts, and immunocytochemistry. High concentrations of NPY were identified throughout the heart and within the major blood vessels of the rat in particular in the renal...

journal_title：Cardiovascular research

authors： Allen JM,Polak JM,Rodrigo J,Darcy K,Bloom SR

更新日期：1985-09-01 00:00:00

abstract：AIMS:Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to ...

journal_title：Cardiovascular research

authors： Fernández-Mariño AI,Porras-González C,González-Rodríguez P,Selent J,Pastor M,Ureña J,Castellano A,Valverde MA,Fernández-Fernández JM

更新日期：2012-07-01 00:00:00

abstract：:Experimental studies have provided evidence that the autonomic nervous activity is modulated by oestrogen. Such modulation at central and peripheral levels tends to suppress sympathetic but elevate parasympathetic tone to the cardiovascular system. Thus, available data support the view that cardiovascular protection b...

journal_title：Cardiovascular research

authors： Du XJ,Riemersma RA,Dart AM

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the underlying mechanisms are still unknown. In this study, we investigated in isolated rat cardiomyocytes subjected to hypoxia and reoxygenation whether administration of insulin during reo...

journal_title：Cardiovascular research

authors： Abdallah Y,Gkatzoflia A,Gligorievski D,Kasseckert S,Euler G,Schlüter KD,Schäfer M,Piper HM,Schäfer C

更新日期：2006-05-01 00:00:00

abstract：:The static mechanical properties of major branches of the human arteries (common carotid artery, abdominal aorta, femoral artery, and brachial artery) were studied in 39 subjects, aged 6-81 years, using an ultrasonic phase locked echo tracking system that allows continuous transcutaneous measurement of the diameter of...

journal_title：Cardiovascular research

authors： Kawasaki T,Sasayama S,Yagi S,Asakawa T,Hirai T

更新日期：1987-09-01 00:00:00

abstract：:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

journal_title：Cardiovascular research

authors： Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Research in the pathophysiology of ischemia/reperfusion or redox signaling is hindered by lack of simple methodology to measure short-lived oxygen radicals. In the presence of hydroxyl radical ((*)OH), d-phenylalanine (d-Phe) yields para-, meta- and ortho-tyrosine. We have previously demonstrated that d-Phe c...

journal_title：Cardiovascular research

authors： Biondi R,Ambrosio G,Liebgott T,Cardounel AJ,Bettini M,Tritto I,Zweier JL

更新日期：2006-07-15 00:00:00

abstract：OBJECTIVES:Epidemiological evidence in humans suggests that intrauterine growth retardation is associated with an increased risk of hypertension and coronary heart disease in later life. To begin to understand the mechanisms involved, we developed and exploited a rat model of intrauterine growth retardation to assess p...

journal_title：Cardiovascular research

authors： Hu XW,Levy A,Hart EJ,Nolan LA,Dalton GR,Levi AJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of the Na, K pump current (I(p)) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate whether I(p) contributes to the changes in APD and ERP associated with chronic atrial fibrillation (AF). METHODS:Action potentials...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2003-09-01 00:00:00

abstract：:Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases which are best known for their ability to proteolyse extracellular matrix proteins throughout the body, including the cardiovascular system. Increased MMP-2 activity has been demonstrated in myocardial ischaemia and reperfusion injury and...

journal_title：Cardiovascular research

authors： Kandasamy AD,Chow AK,Ali MA,Schulz R

更新日期：2010-02-01 00:00:00

abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

journal_title：Cardiovascular research

authors： Fishbein MC,Kulber D,Stancl M,Edwalds G

更新日期：1986-01-01 00:00:00

abstract：:Sprouting angiogenesis is an invasive process that involves proteolytic activities required for the degradation of the endothelial basement membrane, cell migration with removal of obstructing matrix proteins, and generation of space in the matrix to allow endothelial cells to form a proper lumen. In the last decade i...

journal_title：Cardiovascular research

authors： van Hinsbergh VW,Koolwijk P

更新日期：2008-05-01 00:00:00

abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

journal_title：Cardiovascular research

authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

更新日期：2019-01-01 00:00:00

abstract：AIMS:The effects of serelaxin, a recombinant form of human relaxin-2 peptide, on vascular function in the coronary microvascular and systemic macrovascular circulation remain largely unknown. This mechanistic, clinical study assessed the effects of serelaxin on myocardial perfusion, aortic stiffness, and safety in pati...

journal_title：Cardiovascular research

authors： Corcoran D,Radjenovic A,Mordi IR,Nazir SA,Wilson SJ,Hinder M,Yates DP,Machineni S,Alcantara J,Prescott MF,Gugliotta B,Pang Y,Tzemos N,Semple SI,Newby DE,McCann GP,Squire I,Berry C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Current guidelines are controversial regarding exercise intensity in cardiovascular prevention and rehabilitation. Although high-intensity training induces larger increases in fitness and maximal oxygen uptake (VO(2max)), moderate intensity is often recommended as equally effective. Controlled preclinical stu...

journal_title：Cardiovascular research

authors： Kemi OJ,Haram PM,Loennechen JP,Osnes JB,Skomedal T,Wisløff U,Ellingsen Ø

更新日期：2005-07-01 00:00:00

abstract：AIMS:Smad7 plays a negative regulatory role in many inflammatory diseases, but its effect on hypertensive disease remains unknown. The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II)-mediated hypertensive cardiac remodelling. METHODS AND RESUL...

journal_title：Cardiovascular research

authors： Wei LH,Huang XR,Zhang Y,Li YQ,Chen HY,Yan BP,Yu CM,Lan HY

更新日期：2013-09-01 00:00:00

abstract：AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

journal_title：Cardiovascular research

authors： Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

更新日期：2012-01-01 00:00:00