Heparin effect on plasma fibrinogen in the thrombophilic syndrome.

Abstract:

:The effects of heparin were studied in a group of 42 patients with preinfarction angina (PA) and acute myocardial infarction (AMI) whose plasma fibrinogen was increased. Plasma fibrinogen was measured by the turbidimetric method in timol turbidimetric units. Statistically significant results proved that heparin reduces the plasma fibrinogen progressively over a treatment period of 6 weeks. During the first three weeks a dose of 1 cc (50 mg or 5000 IU) was given by intravenous injection at 6-h intervals, this was followed by a dose of 2 cc (100 mg or 10,000 IU) given by subcutaneous injection at 12-h intervals for a further three weeks. Hyperfibrinogenemia is perhaps one of the most important factors in the thrombophilic syndrome, and at the same time it is one of the fundamental physiopathological alterations observed in AMI and PA. Because heparin reduces hyperfibrinogenemia it has a beneficial effect in these diseases.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Ruggiero HA,Castellanos H,Caprissi LF,de Caprissi ES,Ruggiero LH

doi

10.1002/clc.4960060504

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

212-6

issue

5

eissn

0160-9289

issn

1932-8737

journal_volume

6

pub_type

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